organism/neuron/soma.md

# soma.md

Qui comprendiamo:

- SOMA: il soma
- VGSC-SOMA-H: Na ion channels. Open only when VDB high
- VGSC-SOMA-M: Na ion channels. Open only when VDB medium
- VGSC-SOMA-L: Na ion channels. Open only when VDB low

## SOMA: Container

---

**Simplified verifiable behaviors**:

— ms:

- Resting at -70 mV: Leak channels + pumps (keep at resting)
- VDB Depolarization : ~1-2 ms: Na⁺ enters (some VGSCs open)
- Opened VGSC and then remain closed for a refractory period
- Spike if depolarized above threshold: to -50 mV
- Ca2+ enter
- Repolarization to -70 mV:  ~1-2 ms: K⁺ exits (VG K⁺ channels open) ← NOT pumps!
- After-hyperpolarization: ~5-20 ms: K⁺ channels still open

— secs:

- Return to exact -70 mV: ~100-1000 ms: Na⁺/K⁺ pumps restore gradients
- Ca2+ accumulation

— mins:

- VGSC modulation

---

**G expression**:

— ms:

- Here the threshold is based only on the integration of Na+
- The threshold is tuned during the spiketrain. Low threshold at rest, to increase sensitivity, threshold increase during spike to increase discrimination
- increase SpikeTrainTraces (fast at spike)
- increase Ca2+ traces

- fast pump which decreases Na+, we do not model K+

- must figure out how to deal with deoplarization
- decrease SpikeTraintraces slow, only if away from spiketrain this is empty

— secs:

- SpikeTrainTraces

— mins:

---

**Tubs:**

- **VDB**: dendrites deliver current

- **Na**: are a proxy for the Coulombs of charge building up on the somatic membrane. They are used to check threshold, but also to mimic Na+ and K+ pumping

- **AP**:

- **bAP**:

- **Ca2+**: Medium term traces to guide tuning and Night development. It is a local trace, ATP is a global (Astrocyte)

- **SpikeTrainTraces**: sono le tracce che consentono al neurone di far partire il Tuning neuronale, quando e' lontano da uno spike-train, ovvero e' in riposo.

---

```Gen
container: SOMA

  expansion: 
    - VGSC-SOMA-H ( fullness: 50x, active: 20x, emptiness: 10x ) 
      # modulated_by: VGSC-SOMA-H-TUN # possible/actual

    - VGSC-SOMA-M ( fullness: 50x, active: 20x, emptiness: 10x ) 
      # modulated_by: VGSC-SOMA-M-TUN # possible/actual

    - VGSC-SOMA-L ( fullness: 50x, active: 20x, emptiness: 10x ) 
      # modulated_by: VGSC-SOMA-L-TUN # possible/actual


  tub_local:

    - VDB

    - Na

    - Ca2+

  tub_intricated:  
    - SpikeTrainTraces ( contained_in: DAY-N )
```

### ms: SOMA

#### CheckVDB: Context

As dendrites deliver current (VDB​), the soma acts like a capacitor. It "stores" this charge in the form of membrane potential. This contextualizes VGSC-SOMA to open ion channels that let Na+ ions in.

This only applies if not AP, or in other words, SOMA is not in refractory period.

```Gen
context: CheckVDB
  contained_by: SOMA

  in_context: Fixed
  rf: ( active: 60x )

  condition: (VDB fullness ) AND NOT AP
    out_context: VDBMax

  condition: ( VDB mediumness ) AND NOT AP
    out_context: VDBMedium 

  condition: ( VDB emptiness ) AND NOT AP
    out_context: VDBLow
```

#### CheckSomaSpike: Context

The initiation and duration of a spike

```Gen
context: CheckSomaSpike
  contained_by: SOMA

  in_context: Fixed
  rf: ( active: 60x )

  condition: ( Na fullness OR APRefractory )
    out_context: AP
    out_context: bAP
```

#### SomaSpike: Episode

```Gen
episode: SomaSpike
  contained_by: SOMA

  in_context: AP
  rf: ( active: 8x )

 hypothesis: 
  action: 
  trace: 
```

#### ClearNa: Episode

```Gen
episode: ClearNa
  contained_by: SOMA

  in_context: Fixed
  rf: ( active: 8x )

 hypothesis: 
  action: 
  trace: 
```

### sec: SOMA

### min: SOMA

#### VGSC-SOMA-TUN: Tuner

```Gen
tuner: VGSC-SOMA-TUN

 contained_by: SOMA

 tunes: SOMA/expansion/VGSC-SOMA

 context_intricated:
  - TunPossible ( contained_by: DAY-N )

 tub_local:

 tub_intricated:
```

##### Check: Context

```Gen
context: Check
  contained_by: VGSC-SOMA-TUN

  in_context: TunPossible
  rf: ( active: 60x )

  condition:  
  out_context: TunSomaVcgg
```

##### ?: Episode

```Gen
episode: ?
  contained_by: TUN-PRE-VGCC

  in_context: TunSomaVcgg
  rf: ( active: x )

 hypothesis:  
  action: 
  trace: 
```

## VGSC-SOMA-H: Container

Voltage Gated Sodium Channel: difficult to open (High)

```Gen
container: VGSC-SOMA-H

  tub_local:
    Ready ( )

  tub_intricated:
    Na ( contained_in: SOMA)
```

### sec: VGSC-SOMA-H

#### NaEnterH: Episode

Se metto il controllo sulla (NOT Ready fullness) il VGSC puo' far entrare un numero di Na non superiore ad un massimo.

```Gen
episode: NaEnterH
  contained_by: VGSC-H-SOMA

  in_context: VDBMax AND ( NOT RefractoryH )
  rf: ( active: 1x )

  hypothesis: ( NOT Na fullness ) AND ( NOT ReadyH fullness )
    action: [ Na increase, ReadyH increase ]
    trace: None
```

##### CheckRefractoryH: Context

Il check su refractory deve essere fatto ad un RF maggiore della eliminazione di Refractory. Questo perche' e' un era nella qualle avviene l'episodio.

```Gen
context: CheckRefractoryH
  contained_by: VGSC-H-SOMA

  in_context: NOT RefractoryH
  rf: ( active: 60x )

  condition: ( ReadyH fullness )
    out_context: RefractoryH
```

##### RefractoryH: Episode

Questo episodio deve girare varie volte nell'ambito del contesto di refractory che viene controllato ad un RF maggiore.

```Gen
episode: RefractoryH
  contained_by: VGSC-H-SOMA

  in_context: RefractoryH
  rf: ( active: 1x )

  hypothesis: NOT ( Ready emptyness )  
    action: [ Ready decrease ]
    trace: None
```

## VGSC-SOMA-M: Container

Voltage Gated Sodium Channel

```Gen
container: VGSC-SOMA-M

```

### sec: VGSC-SOMA-M

#### Episode2

```Gen
episode: ??
  contained_by: VGSC-M-SOMA

  in_context: xxx
  rf: ( active: 1x )

  hypothesis:  
    action: 
    trace: None
```

## VGSC-SOMA-L: Container

Voltage Gated Sodium Channel

```Gen
container: VGSC-SOMA-M

```

### sec: VGSC-SOMA-L

#### Episode3

```Gen
episode: ??
  contained_by: VGSC-L-SOMA

  in_context: xxx
  rf: ( active: 1x )

  hypothesis:  
    action: 
    trace: None
```