behaviors
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-15
@@ -11,37 +11,51 @@ Qui comprendiamo:
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---
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**Simplified behaviors**:
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**Simplified verifiable behaviors**:
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— ms:
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— ms:
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- Resting at -70 mV: Leak channels + pumps (keep at resting)
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- Resting at -70 mV: Leak channels + pumps (keep at resting)
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-- ?
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- VDB Depolarization : ~1-2 ms: Na⁺ enters (some VGSCs open)
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- VDB Depolarization : ~1-2 ms: Na⁺ enters (some VGSCs open)
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- Opened VGSC remain closed for a refractory period
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- Opened VGSC and then remain closed for a refractory period
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Spike if depolarized above threshold: to -50 mV
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- Spike if depolarized above threshold: to -50 mV
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-- Here the threshold is based only on the integration of Na+
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- Ca2+ enter
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-- The threshold is tuned during the spiketrain. Low threshold at rest, to increase sensitivity, threshold increase during spike to increase discrimination
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-- increase SpikeTrainTraces (fast at spike)
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-- increase Ca2+ traces
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- Repolarization to -70 mV: ~1-2 ms: K⁺ exits (VG K⁺ channels open) ← NOT pumps!
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- Repolarization to -70 mV: ~1-2 ms: K⁺ exits (VG K⁺ channels open) ← NOT pumps!
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-- fast pump which decreases Na+, we do not model K+
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- After-hyperpolarization: ~5-20 ms: K⁺ channels still open
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- After-hyperpolarization: ~5-20 ms: K⁺ channels still open
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-- must figure out how to deal with deoplarization
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-- decrease SpikeTraintraces slow, only if away from spiketrain this is empty
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— seconds:
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— secs:
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- Return to exact -70 mV: ~100-1000 ms: Na⁺/K⁺ pumps restore gradients
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- Return to exact -70 mV: ~100-1000 ms: Na⁺/K⁺ pumps restore gradients
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-- slow pump
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- Ca2+ accumulation
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- Ca2+ accumulation: SpikeTrainTraces
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-- ?
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— mins:
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— mins:
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- VGSC modulation
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- VGSC modulation
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---
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---
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**G expression**:
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— ms:
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- Here the threshold is based only on the integration of Na+
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- The threshold is tuned during the spiketrain. Low threshold at rest, to increase sensitivity, threshold increase during spike to increase discrimination
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- increase SpikeTrainTraces (fast at spike)
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- increase Ca2+ traces
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- fast pump which decreases Na+, we do not model K+
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- must figure out how to deal with deoplarization
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- decrease SpikeTraintraces slow, only if away from spiketrain this is empty
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— secs:
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- SpikeTrainTraces
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— mins:
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---
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**Tubs:**
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**Tubs:**
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- **VDB**: dendrites deliver current
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- **VDB**: dendrites deliver current
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