diff --git a/neuron/soma.md b/neuron/soma.md index 3f1af50..99633c6 100644 --- a/neuron/soma.md +++ b/neuron/soma.md @@ -11,37 +11,51 @@ Qui comprendiamo: --- -**Simplified behaviors**: +**Simplified verifiable behaviors**: — ms: - Resting at -70 mV: Leak channels + pumps (keep at resting) --- ? - VDB Depolarization : ~1-2 ms: Na⁺ enters (some VGSCs open) -- Opened VGSC remain closed for a refractory period - Spike if depolarized above threshold: to -50 mV - -- Here the threshold is based only on the integration of Na+ - -- The threshold is tuned during the spiketrain. Low threshold at rest, to increase sensitivity, threshold increase during spike to increase discrimination - -- increase SpikeTrainTraces (fast at spike) - -- increase Ca2+ traces +- Opened VGSC and then remain closed for a refractory period +- Spike if depolarized above threshold: to -50 mV +- Ca2+ enter - Repolarization to -70 mV: ~1-2 ms: K⁺ exits (VG K⁺ channels open) ← NOT pumps! --- fast pump which decreases Na+, we do not model K+ - After-hyperpolarization: ~5-20 ms: K⁺ channels still open --- must figure out how to deal with deoplarization --- decrease SpikeTraintraces slow, only if away from spiketrain this is empty -— seconds: +— secs: - Return to exact -70 mV: ~100-1000 ms: Na⁺/K⁺ pumps restore gradients --- slow pump -- Ca2+ accumulation: SpikeTrainTraces --- ? +- Ca2+ accumulation + — mins: - VGSC modulation --- +**G expression**: + +— ms: + +- Here the threshold is based only on the integration of Na+ +- The threshold is tuned during the spiketrain. Low threshold at rest, to increase sensitivity, threshold increase during spike to increase discrimination +- increase SpikeTrainTraces (fast at spike) +- increase Ca2+ traces + +- fast pump which decreases Na+, we do not model K+ + +- must figure out how to deal with deoplarization +- decrease SpikeTraintraces slow, only if away from spiketrain this is empty + +— secs: + +- SpikeTrainTraces + +— mins: + +--- + **Tubs:** - **VDB**: dendrites deliver current