This commit is contained in:
2026-03-22 11:47:43 +01:00
parent d765205654
commit 163c6adee7
2 changed files with 22 additions and 73 deletions
+8
View File
@@ -24,6 +24,14 @@ Mentre la scelta di mettere un comportamento in DEV rispetto a BEH e' chiara (ca
Il **DEV** lavora durante Night a tempi lunghi rispetto a BEH e TUN. In pratica cambia la forma delle possibilita nell'ambito delle quali "agisce" BEH. Il DEV contiene quei behavior di modulazione che cambiano **fullness** di un Tub e **RF** di un context o episode. Ovvero ce creazione di nuova “forma” di possibilita in BEH. Il **DEV** lavora durante Night a tempi lunghi rispetto a BEH e TUN. In pratica cambia la forma delle possibilita nell'ambito delle quali "agisce" BEH. Il DEV contiene quei behavior di modulazione che cambiano **fullness** di un Tub e **RF** di un context o episode. Ovvero ce creazione di nuova “forma” di possibilita in BEH.
C'e' una differenza se il cambio di fullness e' su un Tub di tipo floor (esempio Ca2+) o su un Tub di tipo concettuale (esempio BEH-PRE). Nel caso del Tub concettuale, il cambio di fullness determina un cambiamento di forma piu' "marcato" perche' l'enliver deve collegare o scollegare intricazioni fra concetti. C'e' una differenza se il cambio di fullness e' su un Tub di tipo floor (esempio Ca2+) o su un Tub di tipo concettuale (esempio BEH-PRE). Nel caso del Tub concettuale, il cambio di fullness determina un cambiamento di forma piu' "marcato" perche' l'enliver deve collegare o scollegare intricazioni fra concetti.
### Context and Episode
Il context e' a RF piu' alto, che attiva la possibilita' di un episode a RF piu' basso. L'episode "dura" in un intervallo di context. Il context puo' integrare le ipotesi fatte durante l'episode.
### Condition, hypothesis
...
### Tub / Blocchi ### Tub / Blocchi
Il concetto di tub / blocco e' una maniera di vedere in due modi diversi. Come contenitore di blocchi, e come blocco. Il concetto di tub / blocco e' una maniera di vedere in due modi diversi. Come contenitore di blocchi, e come blocco.
+14 -73
View File
@@ -29,14 +29,16 @@ container: BEH-AXO
--- ---
**Fast — 1 ms**: **Fast — ms**:
- AP fires → membrane jumps to peak, decays toward rest (Na/K-ATPase recharge). Here we do not comprehend the decay. - AP fires → membrane jumps to peak, decays toward rest (Na/K-ATPase recharge). Here we do not comprehend the decay.
- ATP cost charged per AP (Here we can comprehend it with an integrator) - ATP cost charged per AP (Here we can comprehend it with an integrator)
- Ca²⁺ enters via VGCCs, gated by CDI, eCB, and mGluR suppression - Ca²⁺ enters via VGCCs, gated by CDI, eCB, and mGluR suppression
- ATP cost charged per unit Ca²⁺ cleared. Here we charge per Ca2+ entered - ATP cost charged per unit Ca²⁺ cleared. Here we charge per Ca2+ entered
- CDI rises with Ca²⁺, recovers when Ca²⁺ is low - CDI (calcium-dependent inactivation of VGCCs)
- Ca²⁺ trace integrates toward Tr_Ca -- CDI rises with Ca2+ each ms: accumulates across inter-spike intervals under pump failure
-- CDI recovers when Ca2+ is low: rate -> 0 when Ca2+ is high — the self-locking feedback
- Ca²⁺ trace integrates toward CaTraces
- Vesicles release from RRP, based on CaMicro and RRP, suppressed by NT_cleft - Vesicles release from RRP, based on CaMicro and RRP, suppressed by NT_cleft
- NT added to cleft - NT added to cleft
- NT_released_this_window accumulates (feeds Medium) - NT_released_this_window accumulates (feeds Medium)
@@ -45,18 +47,18 @@ container: BEH-AXO
--- ---
**Medium — 1 s**: **Medium — seconds**:
- Astrocyte EAATs clear 30% of remaining NT_cleft (Astrocyte behavior) - Astrocyte EAATs clear 30% of remaining NT_cleft (Astrocyte behavior)
- IP3 integrates NT_released_this_window (cumulative burst load) - IP3 integrates NT_released_this_window (cumulative burst load)
- If IP3 exceeds threshold → astrocyte Ca²⁺ wave triggered - If IP3 exceeds threshold → astrocyte Ca²⁺ wave triggered
- mGluR autoreceptor activation updates from NT_released_this_window - mGluR autoreceptor activation updates from NT_released_this_window
- eCB retrograde signal updates from V_post history (from postsynapse) - eCB retrograde signal updates from V_post history (from postsynapse)
- RP → RRP recruitment runs (rate gated by Tr_Ca, costs ATP) - RP → RRP recruitment runs (rate gated by CaTraces, costs ATP)
--- ---
**Slow — 1 min**: Metabolic **Slow — mins**: Metabolic
- Glucose level sets metabolic health - Glucose level sets metabolic health
- ATP_demand (accumulated from Loop 1) reduces ATP_level - ATP_demand (accumulated from Loop 1) reduces ATP_level
@@ -65,23 +67,14 @@ container: BEH-AXO
--- ---
**Actors**:
- CDI (calcium-dependent inactivation of VGCCs)
-- CDI rises with Ca_micro each ms: accumulates across inter-spike intervals under pump failure
-- CDI recovers when Ca_micro is low: rate -> 0 when Ca_micro is high — the self-locking feedback
---
**Tubs:** **Tubs:**
- **Ca2+**: Calcium Ion entering the Presynapse when VCGG open. - **Ca2+**: Calcium Ion entering the Presynapse when VCGG open that influence NT release. Normally returns to ~0 between spikes; stays elevated when pumps fail. They are key to check the concentration, release vescicles and modulation
- **Ca2Micro**: free cytosolic Ca2+ in microdomain that influence NT release. Normally returns to ~0 between spikes; stays elevated when pumps fail. They are key to check the concentration, release vescicles and modulation
- **Rrp**: Readily Releasable Pool: The Readily Releasable Pool consists of the vesicles that are "docked" and "primed" at the active zone of the synapse. - **Rrp**: Readily Releasable Pool: The Readily Releasable Pool consists of the vesicles that are "docked" and "primed" at the active zone of the synapse.
-- Location: Directly touching the presynaptic membrane. -- Location: Directly touching the presynaptic membrane.
-- Function: These are the first to be released when an action potential arrives. -- Function: These are the first to be released when an action potential arrives.
-- Characteristics: This pool is very small (usually only about 0.5% to 5% of total vesicles) and can be exhausted quickly during high-frequency firing, leading to "short-term depression" of the signal. -- Characteristics: This pool is very small (usually only about 0.5% to 5% of total vesicles) and can be exhausted quickly during high-frequency firing, leading to "short-term depression" of the signal.
- **ReservePool**: The "Reserve Pool" - **Rp**: The "Reserve Pool"
-- Location: The bulk of the vesicles held further back in the terminal, often tethered by a protein called synapsin. -- Location: The bulk of the vesicles held further back in the terminal, often tethered by a protein called synapsin.
-- Function: These are only mobilized during intense, prolonged stimulation once the RRP. -- Function: These are only mobilized during intense, prolonged stimulation once the RRP.
-- Characteristics: This makes up the vast majority of the vesicles (up to 80% or 90%). -- Characteristics: This makes up the vast majority of the vesicles (up to 80% or 90%).
@@ -98,8 +91,6 @@ container: BEH-PRE
- Ca2+ ( fullness: 60x, active: 30x, emptiness: 0x ) - Ca2+ ( fullness: 60x, active: 30x, emptiness: 0x )
# developed_by: DEV-PRE-CA2+FULL from DEV.N # developed_by: DEV-PRE-CA2+FULL from DEV.N
- CaMicro ( fullness: 60x, active: 30x, emptiness: 0x )
- Rrp ( fullness: 30x, active: 15x, emptiness: 0x ) - Rrp ( fullness: 30x, active: 15x, emptiness: 0x )
# developed_by: DEV-PRE-RRP-FULL from DEV.N # developed_by: DEV-PRE-RRP-FULL from DEV.N
@@ -224,13 +215,13 @@ episode: NTreleaseLow
... ...
#### mGlur #### mGlur concentration
#### eCB #### eCB concentration
#### CDI #### CDI concentration
#### RP->RRP #### RP->RRP shuttling
### min: behavior ### min: behavior
@@ -251,56 +242,6 @@ container: BEH-PRE-VGCC
- AP ( contained_by: BEH-SOMA ) - AP ( contained_by: BEH-SOMA )
``` ```
### VGCC-Breaking: Contexts
#### CDIConcentration: Context
```Gen
context: CDIConcentration
contained_by: BEH-PRE-VGCC
in_context: AP
rf: ( active: 60x )
condition: NOT (Ca2Micro empty) AND NOT (Ca2Micro full)
out_context: Ca2MicroMedium
condition: (Ca2Micro full)
out_context: Ca2MicroFull
```
#### eCBConcentration: Context
```Gen
context: eCBConcentration
contained_by: BEH-PRE-VGCC
in_context: AP
rf: ( active: 60x )
condition: NOT (Ca2Micro empty) AND NOT (Ca2Micro full)
out_context: Ca2MicroMedium
condition: (Ca2Micro full)
out_context: Ca2MicroFull
```
#### mGluRConcentration: Context
```Gen
context: mGluRConcentration
contained_by: BEH-PRE-VGCC
in_context: AP
rf: ( active: 60x )
condition: NOT (Ca2Micro empty) AND NOT (Ca2Micro full)
out_context: Ca2MicroMedium
condition: (Ca2Micro full)
out_context: Ca2MicroFull
```
### Ca2+enter: Episodes ### Ca2+enter: Episodes
Here we comprehend the breaking activity on VGCC by: CDI,eCB and mGluR: Here we comprehend the breaking activity on VGCC by: CDI,eCB and mGluR: