varie
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@@ -24,6 +24,14 @@ Mentre la scelta di mettere un comportamento in DEV rispetto a BEH e' chiara (ca
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Il **DEV** lavora durante Night a tempi lunghi rispetto a BEH e TUN. In pratica cambia la forma delle possibilita’ nell'ambito delle quali "agisce" BEH. Il DEV contiene quei behavior di modulazione che cambiano **fullness** di un Tub e **RF** di un context o episode. Ovvero c’e’ creazione di nuova “forma” di possibilita’ in BEH.
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C'e' una differenza se il cambio di fullness e' su un Tub di tipo floor (esempio Ca2+) o su un Tub di tipo concettuale (esempio BEH-PRE). Nel caso del Tub concettuale, il cambio di fullness determina un cambiamento di forma piu' "marcato" perche' l'enliver deve collegare o scollegare intricazioni fra concetti.
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### Context and Episode
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Il context e' a RF piu' alto, che attiva la possibilita' di un episode a RF piu' basso. L'episode "dura" in un intervallo di context. Il context puo' integrare le ipotesi fatte durante l'episode.
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### Condition, hypothesis
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...
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### Tub / Blocchi
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Il concetto di tub / blocco e' una maniera di vedere in due modi diversi. Come contenitore di blocchi, e come blocco.
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+14
-73
@@ -29,14 +29,16 @@ container: BEH-AXO
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---
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**Fast — 1 ms**:
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**Fast — ms**:
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- AP fires → membrane jumps to peak, decays toward rest (Na/K-ATPase recharge). Here we do not comprehend the decay.
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- ATP cost charged per AP (Here we can comprehend it with an integrator)
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- Ca²⁺ enters via VGCCs, gated by CDI, eCB, and mGluR suppression
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- ATP cost charged per unit Ca²⁺ cleared. Here we charge per Ca2+ entered
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- CDI rises with Ca²⁺, recovers when Ca²⁺ is low
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- Ca²⁺ trace integrates toward Tr_Ca
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- CDI (calcium-dependent inactivation of VGCCs)
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-- CDI rises with Ca2+ each ms: accumulates across inter-spike intervals under pump failure
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-- CDI recovers when Ca2+ is low: rate -> 0 when Ca2+ is high — the self-locking feedback
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- Ca²⁺ trace integrates toward CaTraces
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- Vesicles release from RRP, based on CaMicro and RRP, suppressed by NT_cleft
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- NT added to cleft
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- NT_released_this_window accumulates (feeds Medium)
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@@ -45,18 +47,18 @@ container: BEH-AXO
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---
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**Medium — 1 s**:
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**Medium — seconds**:
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- Astrocyte EAATs clear 30% of remaining NT_cleft (Astrocyte behavior)
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- IP3 integrates NT_released_this_window (cumulative burst load)
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- If IP3 exceeds threshold → astrocyte Ca²⁺ wave triggered
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- mGluR autoreceptor activation updates from NT_released_this_window
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- eCB retrograde signal updates from V_post history (from postsynapse)
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- RP → RRP recruitment runs (rate gated by Tr_Ca, costs ATP)
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- RP → RRP recruitment runs (rate gated by CaTraces, costs ATP)
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---
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**Slow — 1 min**: Metabolic
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**Slow — mins**: Metabolic
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- Glucose level sets metabolic health
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- ATP_demand (accumulated from Loop 1) reduces ATP_level
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@@ -65,23 +67,14 @@ container: BEH-AXO
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---
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**Actors**:
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- CDI (calcium-dependent inactivation of VGCCs)
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-- CDI rises with Ca_micro each ms: accumulates across inter-spike intervals under pump failure
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-- CDI recovers when Ca_micro is low: rate -> 0 when Ca_micro is high — the self-locking feedback
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---
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**Tubs:**
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- **Ca2+**: Calcium Ion entering the Presynapse when VCGG open.
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- **Ca2Micro**: free cytosolic Ca2+ in microdomain that influence NT release. Normally returns to ~0 between spikes; stays elevated when pumps fail. They are key to check the concentration, release vescicles and modulation
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- **Ca2+**: Calcium Ion entering the Presynapse when VCGG open that influence NT release. Normally returns to ~0 between spikes; stays elevated when pumps fail. They are key to check the concentration, release vescicles and modulation
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- **Rrp**: Readily Releasable Pool: The Readily Releasable Pool consists of the vesicles that are "docked" and "primed" at the active zone of the synapse.
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-- Location: Directly touching the presynaptic membrane.
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-- Function: These are the first to be released when an action potential arrives.
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-- Characteristics: This pool is very small (usually only about 0.5% to 5% of total vesicles) and can be exhausted quickly during high-frequency firing, leading to "short-term depression" of the signal.
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- **ReservePool**: The "Reserve Pool"
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- **Rp**: The "Reserve Pool"
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-- Location: The bulk of the vesicles held further back in the terminal, often tethered by a protein called synapsin.
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-- Function: These are only mobilized during intense, prolonged stimulation once the RRP.
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-- Characteristics: This makes up the vast majority of the vesicles (up to 80% or 90%).
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@@ -98,8 +91,6 @@ container: BEH-PRE
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- Ca2+ ( fullness: 60x, active: 30x, emptiness: 0x )
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# developed_by: DEV-PRE-CA2+FULL from DEV.N
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- CaMicro ( fullness: 60x, active: 30x, emptiness: 0x )
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- Rrp ( fullness: 30x, active: 15x, emptiness: 0x )
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# developed_by: DEV-PRE-RRP-FULL from DEV.N
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@@ -224,13 +215,13 @@ episode: NTreleaseLow
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...
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#### mGlur
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#### mGlur concentration
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#### eCB
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#### eCB concentration
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#### CDI
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#### CDI concentration
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#### RP->RRP
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#### RP->RRP shuttling
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### min: behavior
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@@ -251,56 +242,6 @@ container: BEH-PRE-VGCC
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- AP ( contained_by: BEH-SOMA )
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```
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### VGCC-Breaking: Contexts
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#### CDIConcentration: Context
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```Gen
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context: CDIConcentration
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contained_by: BEH-PRE-VGCC
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in_context: AP
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rf: ( active: 60x )
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condition: NOT (Ca2Micro empty) AND NOT (Ca2Micro full)
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out_context: Ca2MicroMedium
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condition: (Ca2Micro full)
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out_context: Ca2MicroFull
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```
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#### eCBConcentration: Context
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```Gen
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context: eCBConcentration
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contained_by: BEH-PRE-VGCC
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in_context: AP
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rf: ( active: 60x )
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condition: NOT (Ca2Micro empty) AND NOT (Ca2Micro full)
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out_context: Ca2MicroMedium
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condition: (Ca2Micro full)
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out_context: Ca2MicroFull
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```
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#### mGluRConcentration: Context
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```Gen
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context: mGluRConcentration
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contained_by: BEH-PRE-VGCC
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in_context: AP
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rf: ( active: 60x )
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condition: NOT (Ca2Micro empty) AND NOT (Ca2Micro full)
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out_context: Ca2MicroMedium
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condition: (Ca2Micro full)
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out_context: Ca2MicroFull
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```
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### Ca2+enter: Episodes
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Here we comprehend the breaking activity on VGCC by: CDI,eCB and mGluR:
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