diff --git a/README.md b/README.md index 05f2cd6..09e52d7 100644 --- a/README.md +++ b/README.md @@ -24,6 +24,14 @@ Mentre la scelta di mettere un comportamento in DEV rispetto a BEH e' chiara (ca Il **DEV** lavora durante Night a tempi lunghi rispetto a BEH e TUN. In pratica cambia la forma delle possibilita’ nell'ambito delle quali "agisce" BEH. Il DEV contiene quei behavior di modulazione che cambiano **fullness** di un Tub e **RF** di un context o episode. Ovvero c’e’ creazione di nuova “forma” di possibilita’ in BEH. C'e' una differenza se il cambio di fullness e' su un Tub di tipo floor (esempio Ca2+) o su un Tub di tipo concettuale (esempio BEH-PRE). Nel caso del Tub concettuale, il cambio di fullness determina un cambiamento di forma piu' "marcato" perche' l'enliver deve collegare o scollegare intricazioni fra concetti. +### Context and Episode + +Il context e' a RF piu' alto, che attiva la possibilita' di un episode a RF piu' basso. L'episode "dura" in un intervallo di context. Il context puo' integrare le ipotesi fatte durante l'episode. + +### Condition, hypothesis + +... + ### Tub / Blocchi Il concetto di tub / blocco e' una maniera di vedere in due modi diversi. Come contenitore di blocchi, e come blocco. diff --git a/neuron/BEH-AXO.md b/neuron/BEH-AXO.md index f46ea7d..39bc7f2 100644 --- a/neuron/BEH-AXO.md +++ b/neuron/BEH-AXO.md @@ -29,14 +29,16 @@ container: BEH-AXO --- -**Fast — 1 ms**: +**Fast — ms**: - AP fires → membrane jumps to peak, decays toward rest (Na/K-ATPase recharge). Here we do not comprehend the decay. - ATP cost charged per AP (Here we can comprehend it with an integrator) - Ca²⁺ enters via VGCCs, gated by CDI, eCB, and mGluR suppression - ATP cost charged per unit Ca²⁺ cleared. Here we charge per Ca2+ entered -- CDI rises with Ca²⁺, recovers when Ca²⁺ is low -- Ca²⁺ trace integrates toward Tr_Ca +- CDI (calcium-dependent inactivation of VGCCs) +-- CDI rises with Ca2+ each ms: accumulates across inter-spike intervals under pump failure +-- CDI recovers when Ca2+ is low: rate -> 0 when Ca2+ is high — the self-locking feedback +- Ca²⁺ trace integrates toward CaTraces - Vesicles release from RRP, based on CaMicro and RRP, suppressed by NT_cleft - NT added to cleft - NT_released_this_window accumulates (feeds Medium) @@ -45,18 +47,18 @@ container: BEH-AXO --- -**Medium — 1 s**: +**Medium — seconds**: - Astrocyte EAATs clear 30% of remaining NT_cleft (Astrocyte behavior) - IP3 integrates NT_released_this_window (cumulative burst load) - If IP3 exceeds threshold → astrocyte Ca²⁺ wave triggered - mGluR autoreceptor activation updates from NT_released_this_window - eCB retrograde signal updates from V_post history (from postsynapse) -- RP → RRP recruitment runs (rate gated by Tr_Ca, costs ATP) +- RP → RRP recruitment runs (rate gated by CaTraces, costs ATP) --- -**Slow — 1 min**: Metabolic +**Slow — mins**: Metabolic - Glucose level sets metabolic health - ATP_demand (accumulated from Loop 1) reduces ATP_level @@ -65,23 +67,14 @@ container: BEH-AXO --- -**Actors**: - -- CDI (calcium-dependent inactivation of VGCCs) --- CDI rises with Ca_micro each ms: accumulates across inter-spike intervals under pump failure --- CDI recovers when Ca_micro is low: rate -> 0 when Ca_micro is high — the self-locking feedback - ---- - **Tubs:** -- **Ca2+**: Calcium Ion entering the Presynapse when VCGG open. -- **Ca2Micro**: free cytosolic Ca2+ in microdomain that influence NT release. Normally returns to ~0 between spikes; stays elevated when pumps fail. They are key to check the concentration, release vescicles and modulation +- **Ca2+**: Calcium Ion entering the Presynapse when VCGG open that influence NT release. Normally returns to ~0 between spikes; stays elevated when pumps fail. They are key to check the concentration, release vescicles and modulation - **Rrp**: Readily Releasable Pool: The Readily Releasable Pool consists of the vesicles that are "docked" and "primed" at the active zone of the synapse. -- Location: Directly touching the presynaptic membrane. -- Function: These are the first to be released when an action potential arrives. -- Characteristics: This pool is very small (usually only about 0.5% to 5% of total vesicles) and can be exhausted quickly during high-frequency firing, leading to "short-term depression" of the signal. -- **ReservePool**: The "Reserve Pool" +- **Rp**: The "Reserve Pool" -- Location: The bulk of the vesicles held further back in the terminal, often tethered by a protein called synapsin. -- Function: These are only mobilized during intense, prolonged stimulation once the RRP. -- Characteristics: This makes up the vast majority of the vesicles (up to 80% or 90%). @@ -98,8 +91,6 @@ container: BEH-PRE - Ca2+ ( fullness: 60x, active: 30x, emptiness: 0x ) # developed_by: DEV-PRE-CA2+FULL from DEV.N - - CaMicro ( fullness: 60x, active: 30x, emptiness: 0x ) - - Rrp ( fullness: 30x, active: 15x, emptiness: 0x ) # developed_by: DEV-PRE-RRP-FULL from DEV.N @@ -224,13 +215,13 @@ episode: NTreleaseLow ... -#### mGlur +#### mGlur concentration -#### eCB +#### eCB concentration -#### CDI +#### CDI concentration -#### RP->RRP +#### RP->RRP shuttling ### min: behavior @@ -251,56 +242,6 @@ container: BEH-PRE-VGCC - AP ( contained_by: BEH-SOMA ) ``` -### VGCC-Breaking: Contexts - -#### CDIConcentration: Context - -```Gen -context: CDIConcentration - contained_by: BEH-PRE-VGCC - - in_context: AP - rf: ( active: 60x ) - - condition: NOT (Ca2Micro empty) AND NOT (Ca2Micro full) - out_context: Ca2MicroMedium - - condition: (Ca2Micro full) - out_context: Ca2MicroFull -``` - -#### eCBConcentration: Context - -```Gen -context: eCBConcentration - contained_by: BEH-PRE-VGCC - - in_context: AP - rf: ( active: 60x ) - - condition: NOT (Ca2Micro empty) AND NOT (Ca2Micro full) - out_context: Ca2MicroMedium - - condition: (Ca2Micro full) - out_context: Ca2MicroFull -``` - -#### mGluRConcentration: Context - -```Gen -context: mGluRConcentration - contained_by: BEH-PRE-VGCC - - in_context: AP - rf: ( active: 60x ) - - condition: NOT (Ca2Micro empty) AND NOT (Ca2Micro full) - out_context: Ca2MicroMedium - - condition: (Ca2Micro full) - out_context: Ca2MicroFull -``` - ### Ca2+enter: Episodes Here we comprehend the breaking activity on VGCC by: CDI,eCB and mGluR: