354 lines
11 KiB
Markdown
354 lines
11 KiB
Markdown
---
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include_toc: true
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---
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// presynapse.md
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**Expansions and modulations**:
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- is expanded and developed by: [AXON](axon.md)
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- is tuned by: [ORGANISM](../../organism.md), organs, modules
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- expands and tunes: [PRE_VGG](pre_vgcc.md)
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- develops _Ca2, _Rrp
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**Introduction**:
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The presynaptic bouton releases neurotransmitter and gathers evidence about whether that release was worth strengthening and worth sustaining. Its behavior unfolds across two DAY contexts and the NIGHT scope.
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During DAY, during AP — the bouton releases neurotransmitter. The amount released depends on:
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- residual calcium from recent spikes (the fast trace), which sets the release drive;
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- the two retrograde messages from the postsynapse — retro_eCB brakes the drive (the postsynapse is over-driven), retro_NO will later confirm that release reached a responsive target;
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- the availability of both fuel and vesicles — release proceeds only if budget covers the cost and the readily-releasable pool is non-empty. These two shortfalls are read differently: a fuel shortfall on a succeeding release is evidence the bouton needs more endurance; an empty pool with fuel to spare is ordinary short-term depression.
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During DAY, during NOT_AP — the bouton consolidates and recovers. With no spike to release, it:
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- receives what arrived — latches the retrograde messages, refills its budget from astrocytic lactate and arrived axonal shipment (contested supply);
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- maintains its traces — accumulates eligibility toward a tag, and stabilizes that tag if dopamine has arrived (the bridge toward strength);
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- recovers its readily-releasable pool from the private reserve, between spikes (which is why high-frequency firing depletes faster than it recovers);
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- lets its traces decay, closing the eligibility, endurance, and tagging windows.
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During NIGHT — the bouton's ceilings are rewritten. Acting on the evidence gathered across the day, NIGHT raises the bouton's structure (active-zone capacity) where a validated tag accumulated, and its budget capacity (mitochondrial endurance) where fuel repeatedly interrupted a succeeding release. Both draw on the same finite material and energy shipped down the axon, so the bouton's two kinds of growth compete — and whatever is not maintained drifts back down.
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# PRESYNAPSE
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```Gen
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PRESYNAPSE
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type: comprehension
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include: pre_vgcc.md
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// ########################## Intrication ##########################
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// Scope
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!DAY: INTRICATE [ scope: &ORGANISM.!DAY ]
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!NIGHT: INTRICATE [ scope: &ORGANISM.!NIGHT ]
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// Context
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*AP: INTRICATE [ context: &SOMA.*AP ]
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*TunPossible: INTRICATE [ context: &NEURON.*TunPossible ]
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// Tub
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_NT: INTRICATE [ tub: &ASTROSYNAPSE._NT ]
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_pre_budget: INTRICATE [ tub: &ASTROCYTE._pre_budget ]
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_eCB: INTRICATE [ tub: &POSTSYNAPSE._eCB ]
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// ########################## Instantiation ##########################
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// Context
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// Tub
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_Ca2: INSTANTIATE [ tub: local, full: 60x, act: 30x, empty: 0x ]
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_Rrp: INSTANTIATE [ tub: local, full: 60x, act: 30x, empty: 0x ]
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_Rp: INSTANTIATE [ tub: local, full: 60x, act: 30x, empty: 0x ]
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_CaTracesHigh: INSTANTIATE [ tub: local, full: 60x, act: 30x, empty: 0x ]
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_CaTracesMedium: INSTANTIATE [ tub: local, full: 60x, act: 30x, empty: 0x ]
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_CaTracesLow: INSTANTIATE [ tub: local, full: 60x, act: 30x, empty: 0x ]
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_Ca2FullDev: INSTANTIATE [ tub: local, full: 60x, act: 30x, empty: 0x ]
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_RrpFullDev: INSTANTIATE [ tub: local, full: 60x, act: 30x, empty: 0x ] // serve al DEV
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// Container
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void: INSTANTIATE [ container: ACTION, scope: !DAY, context: *AP ]
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void: INSTANTIATE [ container: TRACE, scope: !DAY, context: NOT *AP ]
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void: INSTANTIATE [ container: DECAY, scope: !DAY, context: NOT *AP ]
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void: INSTANTIATE [ container: RECOVER, scope: !DAY, context: NOT *AP ]
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void: INSTANTIATE [ container: ADJUST, scope: !DAY, context: *TunPossible ] // Tuning
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void: INSTANTIATE [ container: DEVELOP, scope: !NIGHT, context: ]
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// ########################## Expansion ##########################
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_@pre_vgcc: INSTANTIATE [ tub: EXPAND [ comprehension: PRE_VGCC ], full: 10x, active: 5x, empty: 2x ] // PRE_VGCC, il tub _@pre_vgcc serve al tuning
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```
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## ACTION
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```Gen
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ACTION
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type: container
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// !DAY | *AP
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// ########################## NTRelease | Fast (ms–s) ##########################
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// Devo aggiungere la limitazione dovuta al Glutamate Spillover GluR e retro_eCB !!!!
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NTreleaseLow: INSTANTIATE [ snippet: accumulator, event: 12x ] {
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hypothesis: _Ca2 mediumness AND _Rrp mediumness AND NOT _pre_budget empty
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action: [ _Rrp decrease, _NT increase ]
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cost: [ _pre_budget decrease 3x ]
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else: None
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}
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NTreleaseMedium: INSTANTIATE [ snippet: accumulator, event: 9x ] {
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hypothesis: ( _Ca2 fullness AND _Rrp mediumness ) OR ( _Ca2 mediumness AND _Rrp fullness ) AND NOT _pre_budget empty
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action: [ _Rrp decrease, _NT increase ]
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cost: [ _pre_budget decrease 3x ]
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else: None
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}
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NTreleaseHigh: INSTANTIATE [ snippet: accumulator, event: 6x ] {
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hypothesis: _Ca2 fullness AND _Rrp fullness AND NOT _pre_budget empty
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action: [ _Rrp decrease, _NT increase ]
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cost: [ _pre_budget decrease 3x ]
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else: None
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}
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// ########################## Endurance | Fast (ms–s) ##########################
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// Tag se manca pre_budget, ma il rilascio di NT sarebbe stato di beneficio
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Endourance_tag: INSTANTIATE [ snippet: accumulator, event: 9x ] {
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hypothesis: _pre_budget empty AND NOT deve esserci la possibilita di spikare e altri segnali come NO
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action: [ _pre_endurance_tag increase ]
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cost: None
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else: None
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}
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```
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## TRACE
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```Gen
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TRACE
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type: container
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// !DAY | NOT *AP
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// ########################## _Ca2 level | Short (ms–s) ##########################
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TracesAccLow: INSTANTIATE [ snippet: accumulator, event: 3x ] {
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hypothesis: _Ca2 emptiness
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action: [ _CaTraceLow increase ]
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cost: None
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else: None
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}
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TracesAccMedium: INSTANTIATE [ snippet: accumulator, event: 6x ] {
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hypothesis: _Ca2 mediumness
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action: [ _CaTraceMed increase ]
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cost: None
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else: None
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}
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TracesAccHigh: INSTANTIATE [ snippet: accumulator, event: 10x ] {
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hypothesis: _Ca2 fullness
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action: [ _CaTraceHigh increase ]
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cost: None
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else: None
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}
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// ########################## Long (hr) ##########################
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```
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## DECAY
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```Gen
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DECAY
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type: container
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// !DAY | NOT *AP
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// ########################## TracesClearance | Short (ms–s) ##########################
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TracesClearance: INSTANTIATE [ snippet: accumulator, event: 30x] {
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hypothesis: NOT _CaTraceHigh empty
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action: [ _CaTRaceHigh decrease ]
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cost: None
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else: None
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hypothesis: NOT _CaTraceMedium empty
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action: [ _CaTRaceMedium decrease ]
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cost: None
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else: None
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hypothesis: NOT _CaTraceLow empty
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action: [ _CaTRaceLow decrease ]
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cost: None
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else: None
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}
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// ########################## eCBClearance | Medium (s–min) ##########################
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eCBClearenceMedium: INSTANTIATE [ snippet: accumulator, event: 24x ] {
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hypothesis: NOT _eCB empty
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action: [ _eCB decrease ]
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cost:
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else: None
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}
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eCBClearenceLow: INSTANTIATE [ snippet: accumulator, event: 48x] {
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hypothesis: NOT _eCB empty
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action: [ _eCB decrease ]
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cost:
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else: None
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}
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// ########################## ??? | Long (hr) ##########################
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```
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## RECOVER
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```Gen
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RECOVER
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type: container
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// !DAY | NOT *AP
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// ########################## Rp Shuttle | Short (ms–s) ##########################
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// The "Hard Bottleneck" State. Recruitment is throttled by a lack of signal, a lack of supply, or a lack of space.
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// If even one of these "Near-Stop" conditions is met, the rate cannot exceed "Slow," regardless of the other two conditions.
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// Rate: 0.00 – 0.25
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RPShuttleLow: INSTANTIATE [ snippet: accumulator, event: 24x ] {
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hypothesis: _CaTraceLow fullness OR _RP emptiness OR _Rrp fullness
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action: [ _RP decrease, _Rrp increase ]
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cost:
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else: None
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}
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// The "Sub-Optimal" State. The machinery is working, but it's held back by partial limitations.
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// This covers cases where the signal is steady but the "piston" isn't firing at full speed,
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// or where a high vacancy in the RRP (emptiness) forces a low signal to work a bit harder. Rate: 0.50 – 0.97
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RPShuttleMedium: INSTANTIATE [ snippet: accumulator, event: 48x ] {
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hypothesis: ( _CaTraceMedium fullness AND _RP mediumness AND _Rrp mediumness ) OR
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( _CaTraceHigh fullness AND _RP mediumness AND _Rrp mediumness ) OR # signal boost
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( _CaTraceMedium fullness AND _RP fullness AND _Rrp mediumness ) OR # supply boost
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( _CaTraceMedium fullness AND _RP mediumness AND _Rrp emptiness ) # vacancy boost
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action: [ _RP decrease, _Rrp increase ]
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cost:
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else: None
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}
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// ########################## RefillGlutamine | Medium (s–min) ##########################
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// The "High Performance" State. Multiple systems are optimized, but one is still at a "mediumness" level.
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// This represents an active synapse that hasn't reached its absolute peak because either the supply is only 50%
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// or the \_Rrp isn't empty enough to create that "maximal vacuum" pull. Rate: 1.25 – 1.94
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RefillGlutamine: INSTANTIATE [ snippet: accumulator, event: 24x ] {
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hypothesis: ( _CaTraceHigh fullness AND _RP fullness AND _Rrp mediumness ) OR # signal + supply
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( _CaTraceHigh fullness AND _RP mediumness AND _Rrp emptiness ) OR # signal + vacancy
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( _CaTraceMedium fullness AND _RP fullness AND _Rrp emptiness ) # supply + vacancy
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action: [ _RP decrease, _Rrp increase ]
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cost:
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else: None
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}
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```
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## ADJUST
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```Gen
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ADJUST
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type: container
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// !DAY | *TunPossible
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// ########################## PRE_VGCC Tun | Medium (s–min) ##########################
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// qui stiamo attivando e disattivando PRE_VGCC. Fra un massimo full e minimo empty (empty puo' non essere 0)
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VgccTun: INSTANTIATE [ snippet: accumulator, event: 60x ] {
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condition: _CaTraceHigh fullness
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hypothesis:
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action:
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cost: [ _pre_budget decrease 3x ]
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else:
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condition: _CaTraceLow fullness
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hypothesis:
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action:
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cost: [ _pre_budget increase 3x ]
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else:
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}
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```
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## DEVELOP
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```Gen
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DEVELOP
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type: container
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// !NIGHT | ???
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// ########################## CaFull | ??? ##########################
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Ca2Check: INSTANTIATE [ snippet: accumulator, event: 60x ] {
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condition: ( empty ) // CaFullDecrease
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hypothesis: NOT ( full ) AND NOT ( empty )
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action: [ increase, decrease]
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cost:
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else: None
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condition: ( full) // Ca2FullIncrease
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hypothesis: NOT ( full ) AND NOT ( empty )
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action: [ increase, decrease]
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cost:
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else: None
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}
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// ########################## RRPFull | ??? ##########################
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RrpCheck: INSTANTIATE [ snippet: accumulator, event: 60x ]
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condition: ( empty ) // RrpFullDecrease
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hypothesis: NOT ( full ) AND NOT ( empty )
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action: [ increase, decrease]
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cost:
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else: None
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condition: ( full) // RrpFullIncrease
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hypothesis: NOT ( full ) AND NOT ( empty )
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action: [ increase, decrease]
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cost:
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else: None
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}
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```
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