8.5 KiB
8.5 KiB
BEH-AXO.md
BEH-AXO: Container
BEH-PRE: Container
[as previously defined]
BEH-POST: Container
ms: behaviors
POST-NTContext: Context
— NT_cleft level arriving from presynapse
— Desensitization_level of receptors at this moment
— these two together determine effective NT binding
NTDetection
NTDetectionMaximum: Episode
— NT_cleft full, Desensitization_level empty
— all receptors available, full NT signal
— receptor_conductance rises steeply
NTDetectionHigh: Episode
— NT_cleft full, Desensitization_level medium OR
— NT_cleft medium, Desensitization_level empty
— strong response, partially attenuated
NTDetectionMedium: Episode
— NT_cleft medium, Desensitization_level medium OR
— NT_cleft low, Desensitization_level empty
— moderate response
NTDetectionLow: Episode
— NT_cleft low, Desensitization_level medium OR
— NT_cleft medium, Desensitization_level full
— weak response, most receptors deaf
NTDetectionNone: Episode
— NT_cleft empty OR
— Desensitization_level full
— no effective binding regardless of NT
ReceptorDesensitization
DesensitizationRising: Episode
— NT_cleft sustained high
— receptors accumulate closed state each ms
— attenuates subsequent NTDetection episodes
DesensitizationRecovering: Episode
— NT_cleft low or empty
— receptors recover availability passively
— rate governed by tau_desensitization = 500 ms
VpostDecay
VpostDecayActive: Episode
— receptor_conductance non-zero
— V_post sustained by ongoing NT binding
VpostDecayPassive: Episode
— receptor_conductance near zero
— V_post decays with tau_post_membrane = 20 ms
— inter-burst silence
POST-Ca2+Context: Context
— V_post level (sets Mg block removal)
— NT_cleft level (ligand gate for NMDA)
— together these determine NMDA opening
— coincidence required: both must be non-zero for Ca_post to rise
NMDACoincidence
NMDACoincidenceMaximum: Episode
— NT_cleft full AND V_post full
— Mg block fully lifted, NMDA wide open
— Ca_post surges — LTP territory
NMDACoincidenceHigh: Episode
— NT_cleft full AND V_post medium OR
— NT_cleft medium AND V_post full
— strong Ca_post rise
NMDACoincidenceMedium: Episode
— NT_cleft medium AND V_post medium
— moderate Ca_post rise — LTP/LTD boundary zone
NMDACoincidenceLow: Episode
— NT_cleft low OR V_post low (but not both empty)
— weak Ca_post rise — LTD territory
NMDACoincidenceNone: Episode
— NT_cleft empty OR V_post empty
— one gate closed — Ca_post does not rise
— this is the hard gate: a single missing condition blocks all entry
CaPostClearance
CaPostClearanceHigh: Episode
— ATP_level_post full
— pump_scale_post near 1
— PMCA running at full rate + NCX
— Ca_post returns to baseline rapidly between events
CaPostClearanceMedium: Episode
— ATP_level_post medium
— pump_scale_post reduced
— Ca_post clears more slowly
— residual elevation between coincidence events
CaPostClearanceLow: Episode
— ATP_level_post low
— pump_scale_post near 0
— only NCX clearing (floor, not rescue)
— Ca_post accumulates across events
— eCB threshold approached without genuine coincidence
— excitotoxicity risk zone
ATPcostPost
— charged every ms:
NKA recharge proportional to V_post level
PMCA cost proportional to cleared_Ca_post_pump
— feeds ATP_demand_post accumulator
— reset in Loop 3
sec: behaviors
POST-SecContext: Context
— Ca_post history over past 2 s (mean of log)
— determines whether eCB synthesis threshold is crossed
— note: driven by Ca_post, not V_post
— ATP failure can push Ca_post above threshold
— without genuine coincidence (false retrograde signal)
eCBSynthesis
eCBSynthesisActive: Episode
— recent_Ca_post > eCB_threshold (0.7)
— eCB synthesised and released retrogradely
— eCB_level rises with tau_eCB_rise = 2000 ms
— suppresses presynaptic VGCCs via effective_conductance
— genuine trigger: sustained NMDA coincidence (overactivity)
— false trigger: Ca_post elevated by pump failure (ATP low)
eCBSynthesisInactive: Episode
— recent_Ca_post < eCB_threshold
— eCB_level decays with tau_eCB_decay = 10000 ms
— presynaptic suppression gradually lifts
min: behaviors
POST-MinContext: Context
— Glucose_level (shared with presynapse)
— ATP_demand_post accumulated since last cycle
— both sides draw from same astrocyte glucose budget
ATPreplenishment
— compute_astrocyte_metabolic_health(Glucose_level, ATP_demand_post)
— produces ATP_level_post for next metabolic window
— ATP_demand_post resets to zero
— when Glucose_level low: both ATP_level and ATP_level_post fall
— presynaptic silence (CDI lock-out) reduces NT release
— reduced NT reduces NMDA activation
— reduced Ca_post reduces ATP_demand_post
— presynaptic silence indirectly protects postsynaptic ATP
BEH-POST-RECEPTOR: Container
ms: behavior Receptors
ReceptorOccupancy
ReceptorOccupancyFull: Episode
— NT_cleft full, Desensitization_level empty
— maximum conductance, V_post rising steeply
ReceptorOccupancyReduced: Episode
— NT_cleft medium OR Desensitization_level medium
— partial conductance
ReceptorOccupancyPartial: Episode
— NT_cleft low OR Desensitization_level high
— weak conductance
ReceptorOccupancySuppressed: Episode
— NT_cleft low AND Desensitization_level high
— near-zero conductance despite NT present
ReceptorOccupancyClosed: Episode
— NT_cleft empty OR Desensitization_level full
— no conductance
BEH-POST-NMDA: Container
ms: behavior NMDA coincidence gate
NMDAgate
NMDAgateFull: Episode
— NT_cleft full AND V_post full
— Mg_block_removal near 1
— Ca_post surges maximally
NMDAgatReduced: Episode
— one condition full, other medium
— partial Mg block removal
— Ca_post rises moderately
NMDAgatPartial: Episode
— both conditions medium
— Mg block partially lifted
— Ca_post rises weakly
NMDAgateSuppressed: Episode
— one condition low, other any
— Mg block mostly intact
— Ca_post minimal rise
NMDAgateClosed: Episode
— either NT_cleft empty OR V_post empty
— hard gate closed
— Ca_post does not rise
Three structural notes on how this mirrors the presynaptic taxonomy.
BEH-POST-NMDA is the postsynaptic equivalent of BEH-PRE-VGCC. Both are containers for a gated calcium entry mechanism. The difference is the gating logic: VGCC is gated by CDI, eCB, and mGluR (three suppressors multiplying together); NMDA is gated by a coincidence requirement (two conditions both required). VGCC can be suppressed by any one of its three brakes acting alone. NMDA can only be blocked by the absence of either NT or depolarisation — a fundamentally different logical structure, AND versus (1 - factor).
NMDACoincidenceNone is a hard gate in the same sense that N_RRP = empty was a hard gate in the NT release table. One missing condition alone is sufficient to prevent all Ca_post entry regardless of the other variable. This makes the postsynaptic calcium system more binary than the presynaptic one — there is no equivalent of the graded suppression that CDI or eCB provide.
eCBSynthesisActive has two distinct biological meanings depending on what is driving Ca_post — genuine overactivity (NMDA coincidence) versus pump failure (ATP depleted). The episode is the same computational event but with opposite implications for whether the retrograde signal is appropriate. This is the only place in the entire model where the same behavior has two different biological interpretations, and it is worth flagging explicitly in any documentation.