21 KiB
Table of Contents
- SCOPE: NIGHT
- {component}_energy and {component}_material used — NOT {component}_budget
- Structural variables WRITTEN. Tags evaluated and cleared.
- Budget variables replenished here for next DAY.
- Step 1 — Replenish All Budgets, Energy, and Material
- Step 2 — Structural Commits (Parallel, Independent)
- Step 3 — Passive Depotentiation
- Step 4 — Homeostatic Scaling
- Step 5 — Clear All Traces
- Summary: Budget Shipment Chain (DAY)
- Summary: Energy and Material Flow
- Flows
- The Abstract Pattern
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Shockwave Lockdown
scope DAY or NIGHT | context OVERLOAD:
// Emergency — bypasses all budget gates
Vm = HYPERPOLARIZED
post_budget -= emergency_reset_cost // DAY cost
AMPA_occupancy = mass_internalization() // receptors to post reserve
axon_fast_trace += overdrive_cluster() // VGCC clustering beneath AZ
astro_budget -= emergency_astro_cost
// Note: in NIGHT, post_energy used if structural receptors affected
SCOPE: NIGHT
{component}_energy and {component}_material used — NOT {component}_budget
Structural variables WRITTEN. Tags evaluated and cleared.
Budget variables replenished here for next DAY.
Step 1 — Replenish All Budgets, Energy, and Material
scope NIGHT | step 1:
// ── ASTROCYTE: root replenishment ───────────────────────────────
astro_budget += overnight_glycolysis(vascular_glucose_supply) × Δt_night
// replenishes fast operational budget for next DAY
astro_energy += overnight_astro_energy_synthesis() × Δt_night
// replenishes structural assembly ATP
astro_material += astrocyte_cellbody_synthesis() × Δt_night
// replenishes: EAAT proteins + racemase + ECM proteins + process cytoskeleton
// ── SOMA: self-replenishment + material production ───────────────
soma_budget += overnight_mitochondria_output() × Δt_night
// replenishes fast operational budget for next DAY
soma_energy += overnight_soma_energy_reserve() × Δt_night
// replenishes structural assembly ATP
soma_material += CREB_driven_synthesis(soma_tag) × Δt_night
// PRIMARY MATERIAL PRODUCTION — rate set by soma_tag magnitude
// this is the production bottleneck for ALL downstream structural commits
// ── MATERIAL DISTRIBUTION: soma → downstream ─────────────────────
// Soma ships structural material to branches and axon
dend_material += soma_material × dend_material_fraction
axon_material += soma_material × axon_material_fraction
soma_material -= (dend_material_fraction + axon_material_fraction) × soma_material
// Branch delivers structural material to spines
post_material += dend_material × spine_material_fraction
dend_material -= spine_material_fraction × dend_material
// Axon delivers structural material to boutons
pre_material += axon_material × bouton_material_fraction
axon_material -= bouton_material_fraction × axon_material
// ── DOWNSTREAM ENERGY REPLENISHMENT ─────────────────────────────
pre_energy += soma_energy × pre_energy_fraction
post_energy += soma_energy × post_energy_fraction
dend_energy += soma_energy × dend_energy_fraction
axon_energy += soma_energy × axon_energy_fraction
// all downstream structural assembly ATP sourced from soma overnight
// ── DOWNSTREAM BUDGET REPLENISHMENT for next DAY ─────────────────
pre_budget += astro_lactate × pre_fraction × Δt_night
post_budget += astro_lactate × post_fraction × Δt_night
dend_budget += astro_lactate × dend_fraction × Δt_night
axon_budget += astro_lactate × axon_fraction × Δt_night
// Note: budgets partially pre-loaded here so components start DAY operational
Step 2 — Structural Commits (Parallel, Independent)
scope NIGHT | step 2:
// Coherence bonus when pre, post, astro all tagged simultaneously
all_aligned = (pre_tag > tag_expiry_threshold and
post_tag > tag_expiry_threshold and
astro_tag > tag_expiry_threshold)
coherence_bonus = all_aligned ? coherence_factor : 1.0
// ── PRE COMMIT ──────────────────────────────────────────────────
if pre_tag > tag_expiry_threshold:
Δpre = min(AZ_expansion_cost,
pre_material,
pre_energy × pre_fraction)
pre_structure += Δpre × coherence_bonus // STRUCTURE WRITTEN
pre_material -= Δpre // consumed — RECOVERABLE
pre_energy -= Δpre × assembly_ATP_cost // consumed — NOT recoverable
if Δpre < AZ_expansion_cost:
queue(pre_deficit → next NIGHT)
// ── POST COMMIT ─────────────────────────────────────────────────
if post_tag > tag_expiry_threshold:
Δpost = min(AMPA_insertion_cost,
post_material,
post_energy × post_fraction)
post_structure += Δpost × coherence_bonus // STRUCTURE WRITTEN
post_material -= Δpost // RECOVERABLE
post_energy -= Δpost × assembly_ATP_cost // NOT recoverable
if Δpost < AMPA_insertion_cost:
queue(post_deficit → next NIGHT)
// ── DEND COMMIT ─────────────────────────────────────────────────
if dend_tag > tag_expiry_threshold:
Δdend = min(branch_expansion_cost,
dend_material,
dend_energy × dend_fraction)
dend_structure += Δdend × coherence_bonus // STRUCTURE WRITTEN
dend_material -= Δdend // RECOVERABLE (partially)
dend_energy -= Δdend × assembly_ATP_cost
if Δdend < branch_expansion_cost:
queue(dend_deficit → next NIGHT)
// ── SOMA COMMIT ─────────────────────────────────────────────────
if soma_tag > tag_expiry_threshold:
Δsoma = min(soma_expansion_cost,
soma_material,
soma_energy × soma_fraction)
soma_structure += Δsoma // STRUCTURE WRITTEN
soma_material -= Δsoma // RECOVERABLE (partially)
soma_energy -= Δsoma × assembly_ATP_cost
// ── AXON COMMIT ─────────────────────────────────────────────────
if axon_tag > tag_expiry_threshold:
Δaxon = min(axon_expansion_cost,
axon_material,
axon_energy × axon_fraction)
axon_structure += Δaxon // STRUCTURE WRITTEN
axon_material -= Δaxon // RECOVERABLE (partially)
axon_energy -= Δaxon × assembly_ATP_cost
if Δaxon < axon_expansion_cost:
queue(axon_deficit → next NIGHT)
// ── ASTRO COMMIT ────────────────────────────────────────────────
if astro_tag > tag_expiry_threshold:
Δastro = min(process_retraction_cost,
astro_material,
astro_energy × astro_fraction)
astro_structure += Δastro × coherence_bonus // STRUCTURE WRITTEN
astro_material -= Δastro // RECOVERABLE (recycling_fraction)
astro_energy -= Δastro × assembly_ATP_cost
if Δastro < process_retraction_cost:
queue(astro_deficit → next NIGHT)
// SELF-REINFORCING: astro_structure ↑ → D_serine_tonic ↑ +
// perisynaptic_distance ↓ → future LTP easier
Step 3 — Passive Depotentiation
scope NIGHT | step 3:
// Potentiation draws material first.
// Remainder distributed as maintenance.
// Below maintenance threshold: structure decays passively.
// Depotentiation = resource neglect, not active depression signal.
remaining_material = total_material_pool - material_consumed_by_commits
maintenance_per_synapse = remaining_material × maintenance_fraction
/ total_synapse_count
for each synapse:
// Structural decay — passive and continuous
pre_structure -= structural_decay_rate × Δt_night
post_structure -= structural_decay_rate × Δt_night
dend_structure -= structural_decay_rate × Δt_night
astro_structure -= structural_decay_rate × Δt_night
// Maintenance counters decay where possible
if maintenance_per_synapse >= maintenance_cost:
pre_structure += maintenance_pre // fully maintained
post_structure += maintenance_post
dend_structure += maintenance_dend
astro_structure += maintenance_astro
else:
pre_structure += maintenance_per_synapse × pre_fraction
post_structure += maintenance_per_synapse × post_fraction
dend_structure += maintenance_per_synapse × dend_fraction
astro_structure += maintenance_per_synapse × astro_fraction
// net: structures drift down — DEPOTENTIATION BY NEGLECT
// LTD material recovery: returned to pools
// Energy NOT recovered — asymmetry justifies separate energy + material in NIGHT
for each synapse where net_structure_change < 0:
recovered = abs(net_structure_change) × recycling_fraction
pre_material += recovered × pre_fraction
post_material += recovered × post_fraction
astro_material += recovered × astro_fraction × recycling_fraction
Step 4 — Homeostatic Scaling
scope NIGHT | step 4:
if soma_tag > homeostatic_ceiling:
scale_factor = homeostatic_ceiling / soma_tag
for each synapse:
post_structure *= scale_factor // STRUCTURE WRITTEN
pre_structure *= scale_factor // STRUCTURE WRITTEN
soma_material += sum(structure_reduction) × recycling_fraction
// energy NOT recovered
Step 5 — Clear All Traces
scope NIGHT | step 5:
// Fast traces: confirmed zero
pre_fast_trace = post_fast_trace = dend_fast_trace = 0
soma_fast_trace = axon_fast_trace = astro_fast_trace = 0
// Possible tagging: confirmed zero
pre_possible_tagging = post_possible_tagging = dend_possible_tagging = 0
soma_possible_tagging = axon_possible_tagging = astro_possible_tagging = 0
// Tags: cleared after commit, carried forward if above threshold
if pre_tag < tag_expiry_threshold: pre_tag = 0
if post_tag < tag_expiry_threshold: post_tag = 0
if dend_tag < tag_expiry_threshold: dend_tag = 0
if soma_tag < tag_expiry_threshold: soma_tag = 0
if axon_tag < tag_expiry_threshold: axon_tag = 0
if astro_tag < tag_expiry_threshold: astro_tag = 0
Summary: Budget Shipment Chain (DAY)
SELF-PRODUCED:
vascular_glucose_supply → astro_budget (astrocyte, CONTINUOUS)
own_mitochondria → soma_budget (soma, NOT_AP)
SHIPMENT CHAIN (DAY operational budgets):
astro_budget → astro_lactate → delivered to all components in their NOT contexts:
→ pre_budget (PRE NOT_AP)
→ post_budget (POST NOT_bAP, via astro_lactate + dend shipment)
→ dend_budget (DEND NOT_bAP, via astro_lactate + soma shipment)
→ axon_budget (AXON NOT_AP, via astro_lactate + soma shipment)
soma_budget → soma_shipment_to_dend → dend_budget (SOMA NOT_AP → DEND NOT_bAP)
soma_budget → soma_shipment_to_axon → axon_budget (SOMA NOT_AP → AXON NOT_AP)
dend_budget → dend_shipment_to_post → post_budget (DEND NOT_bAP → POST NOT_bAP)
axon_budget → axon_shipment_to_pre → pre_budget (AXON NOT_AP → PRE NOT_AP)
MATERIAL SHIPMENT CHAIN (NIGHT structural material):
soma_material → dend_material → post_material (soma → branch → spine)
soma_material → axon_material → pre_material (soma → axon → bouton)
astrocyte_body → astro_material (astrocyte cell body → astrosynapse)
ENERGY DISTRIBUTION (NIGHT assembly ATP):
soma_energy → pre_energy, post_energy, dend_energy, axon_energy
astro_energy → astro structural commits only
Summary: Energy and Material Flow
DAY — {component}_budget (combined fast energy + fast consumables):
vascular_glucose_supply (FIXED)
→ astro_budget (glycolysis ROOT)
→ astro_lactate → pre_budget, post_budget, dend_budget, axon_budget
→ soma_budget (own mitochondria — independent root)
→ axon_budget (partial)
→ dend_budget (partial)
NIGHT — {component}_energy (structural assembly ATP, NOT recoverable):
vascular_glucose_supply (FIXED)
→ astro_energy (overnight glycolysis)
→ soma_energy (overnight mitochondria) → pre_energy, post_energy,
dend_energy, axon_energy
NIGHT — {component}_material (slow structural proteins, RECOVERABLE):
soma (CREB synthesis — soma_tag driven)
→ soma_material
→ dend_material → post_material (spine delivery)
→ axon_material → pre_material (bouton delivery)
astrocyte cell body (overnight synthesis)
→ astro_material (EAAT + racemase + ECM + process cytoskeleton)
LTD recovery flows (material only — not energy):
post LTD → post_material (receptors to dendritic reserve)
pre LTD → pre_material (AZ proteins to axonal pool)
astro LTD → astro_material (ECM fragments, recycling_fraction)
Flows
Per ora abbiamo in DAY il {component}_budget che raggruppa energy e material, e in NIGHT {component}_energy e {component}_material.
This maps onto a real biological distinction. The astrocyte's lactate and the soma's ATP fund the running costs of the cell — everything that needs to happen just to keep the system operating from moment to moment. CREB-driven protein synthesis funds the capital investment — the slow, expensive structural changes that modify what the running system is capable of. These are two different budgets in the biological sense: operating expenditure versus capital expenditure. Combining them within DAY is correct because DAY is entirely operating expenditure. Keeping them separate in NIGHT is correct because NIGHT mixes operating expenditure with capital expenditure, and only the capital component is recoverable.
Combining {component}_energy e {component}_material would hide the fact that dismantling a structure recovers biological building blocks but not the work that was done to assemble them — which is the thermodynamic reality of any construction and deconstruction process.
Energy flow
VASCULAR SUPPLY
→ ASTROCYTE CELL BODY
glucose → lactate (glycolysis)
→ astro_budget (local ATP for clearance, D-serine, ECM, process motility)
→ lactate exported to:
→ pre_budget (ATP for VGCC, vesicle fusion, VATPase)
→ post_budget (ATP for NaK pump, AMPA trafficking, actin)
→ dend_budget (ATP for bAP propagation, local translation)
→ SOMA
soma has own mitochondria — partly self-fueled
soma_budget (ATP for AP generation, CREB, protein synthesis, shipping)
→ dend_budget top-up (organelle delivery)
→ axon_budget top-up (transport machinery)
Material flow
SOMA
protein synthesis (CREB-driven, peaks in NIGHT)
→ soma_material (receptors, scaffold proteins, organelles, mRNA)
→ dend_material (branch receives proteins + mRNA from soma)
→ post_material (spine receives receptors + actin from branch)
→ axon_material (boutons receive AZ proteins + VGCCs from soma via axon)
→ pre_material (bouton active zone proteins)
ASTROSYNAPSE
ECM proteins synthesized in astrocyte cell body
→ astro_material (Glypicans, Thrombospondins, serine for D-serine)
→ cleft environment (ECM sealing, D-serine availability)
Yes, exactly. This is the essential abstract pattern. Let me state it precisely.
The Abstract Pattern
A component operates within a structure set by the previous NIGHT. During DAY, in each context, it executes behaviors that cost budget and deposit fast traces. Fast traces are local records of recent activity that bias the next behavior and open an eligibility window for tagging. A tag forms when a local eligibility signal coincides with one or more non-local validation signals within the decay window of the trace — the number of required coincidences reflecting the spatial scale at which that component sits in the system. In contexts without triggering input, all traces decay, closing the windows they opened. At NIGHT, the tag magnitude drives a structural commit proportional to available material and energy — material being recoverable and energy not — with the structural change becoming the new ceiling within which the next DAY's behaviors will operate. What is not committed decays for lack of maintenance, and the resources freed by that decay partially fund the potentiation of what was.
DAY — The General Form
Every DAY behavior follows this template:
given: STRUCTURE // the architectural ceiling left by NIGHT
in: CONTEXT // local or global triggering condition
if: BUDGET > cost // operational resources available
then: behavior executes
BUDGET -= cost // resources consumed
FAST_TRACE += f(behavior) // local record deposited
The fast trace then drives two parallel processes:
Within the same context — the trace biases the next execution of the same behavior. This is the short-term modulation loop. It is entirely local and requires no external signal.
Across contexts — the trace accumulates into possible_tagging when it exceeds the eligibility threshold. This is the bridge toward long-term change. It requires the trace to be sustained enough to survive into the NOT_AP or CONTINUOUS context.
The Tag Formation — Where Non-Locality Enters
The abstract pattern for tag formation generalizes across all components but with different coincidence requirements:
PRE, DEND, SOMA, AXON, ASTRO — one non-local coincidence:
if FAST_TRACE > eligibility // local: this bouton was recently active
AND dopamine > threshold // non-local: organism-level reward signal
then: TAG += dopamine × possible_tagging
One spatial scale beyond the local component is required. The organism must confirm that the recent activity was worth saving.
POST — two non-local coincidences:
// First coincidence (NOT_bAP context):
if FAST_TRACE > Ca_TAG_threshold // local: spine Ca²⁺ was high
AND D-serine > threshold // non-local 1: astrosynapse co-agonist
then: post_possible_tagging += FAST_TRACE // CANDIDATE
// Second coincidence (bAP context):
if post_possible_tagging > threshold // local: CANDIDATE still present
AND bAP arrives // non-local 2: soma fired
then: FAST_TRACE amplified above Ca_HIGH
// Tag stabilization (any context):
if post_possible_tagging > threshold // local: confirmed coincidence
AND dopamine > threshold // non-local 3: organism validation
then: TAG += dopamine × post_possible_tagging // STABLE
Three spatial scales must align: astrosynapse, soma, organism. The postsynapse is the most constrained component — it requires the most non-local validation before committing.
Trace Recession — The Temporal Behavior
In every NOT_AP or CONTINUOUS context, all traces decay:
FAST_TRACE *= decay(τ_fast) // ms to seconds — closes eligibility window
possible_tagging *= decay(τ_mid) // seconds to minutes — closes tagging window
TAG *= decay(τ_slow) // hours — closes commitment window
The decay is not a separate behavior — it is the passive consequence of molecular processes. But its effect is behavioral: it enforces that coincidences must happen within specific time windows. The system does not check timing explicitly — timing is enforced by the competition between accumulation and decay.
NIGHT — The General Form
given: TAG // strength of DAY evidence for this component
STRUCTURE // current architectural state
if: TAG > threshold // evidence strong enough to justify investment
then:
Δstructure = min(expansion_cost,
MATERIAL, // slow structural resources available
ENERGY × fraction) // assembly ATP available
STRUCTURE += Δstructure × coherence_bonus
MATERIAL -= Δstructure // RECOVERABLE after LTD
ENERGY -= Δstructure × ATP_cost // NOT recoverable
The coherence bonus appears when pre, post, and astro tags are all SET simultaneously — the three components of the synapse have all independently gathered evidence for the same structural change, which amplifies the commit beyond what any single tag would produce alone.
What is not potentiated passively decays:
STRUCTURE -= decay_rate × Δt_night
STRUCTURE += min(maintenance_allocation, maintenance_cost)
// if maintenance_allocation < decay_rate × Δt_night:
// structure drifts down — depotentiation by neglect