119 lines
3.0 KiB
Markdown
119 lines
3.0 KiB
Markdown
# BEH-AXO.md
|
||
|
||
Qui comprendiamo:
|
||
|
||
- BEH-BD: Dendritic Branch
|
||
- BEH-POST: Postsynapsis
|
||
- BEH-POST-AMPA: AMPA receptors (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors)
|
||
|
||
## BEH-BD: Container
|
||
|
||
**Dendritic Branch**: In questa prima fase, non consideriamo lo spike dendritico come comportamento. Questo limita molto il modello, perche' equipara tutte le Postsinapsi sui tre branch dendritici e non permette di fare in maniera che ad esempio due branch contestualizzino (base activity) e uno faccia scattare il threshold per lo spike somatico.
|
||
Qui BEH-DB espande solo i BEH-POST, e' un cavo di collegamento come l'assone
|
||
|
||
```Gen
|
||
Container: BEH-BD
|
||
|
||
expansion:
|
||
- BEH-POST ( fullness: 50x, active: 20x, emptiness: 10x )
|
||
# modulated_by: TUN-SYN-BD-POST possible/actual
|
||
```
|
||
|
||
### BEH-POST: Container
|
||
|
||
```Gen
|
||
container: BEH-POST
|
||
|
||
expansion:
|
||
- BEH-POST-AMPA ( fullness: 10x, active: 5x, emptiness: 2x )
|
||
# modulated_by: TUN-POST-IC # possible/actual
|
||
|
||
tub_local:
|
||
- Ca2+ ( fullness: 60x, active: 30x, emptiness: 0x )
|
||
# modulated_by: DEV-POST-???-FULL # Full
|
||
|
||
- Nox ( fullness: 100x, active: 20x, emptiness: 0x ) # Nitric Oxide (NO): A gas that diffuses freely.
|
||
|
||
- Ecb ( fullness: 100x, active: 20x, emptiness: 0x ) # Endocannabinoids (e.g., 2-AG)
|
||
|
||
tub_intricated:
|
||
- Nt ( contained_by: BEH-SYN )
|
||
- bAp ( contained_by: BEH-SOMA )
|
||
```
|
||
|
||
#### Context
|
||
|
||
```Gen
|
||
context: captureNt
|
||
contained_by: BEH-POST
|
||
|
||
in_context: Fixed
|
||
rf: ( active: 10x )
|
||
|
||
condition: (Nt full) AND NOT (bAp)
|
||
out_context: NtCaptured
|
||
```
|
||
|
||
#### Episode
|
||
|
||
## BEH-POST-AMPA: Container
|
||
|
||
```Gen
|
||
container: BEH-POST-AMPA
|
||
|
||
tub_intricated:
|
||
- Nt ( contained_by: BEH-SYN )
|
||
|
||
context_intricated:
|
||
- bAp ( contained_by: BEH-SOMA )
|
||
```
|
||
|
||
#### AmpaOpen: Episode
|
||
|
||
- Timing: < 1 ms
|
||
- InContext: Glutamate > FULLNESS
|
||
- OutContext: AMPA receptor opening
|
||
- Consequence: Na⁺ influx
|
||
- Consequence: addition to local depolarization (EPSP) from AMPA activation
|
||
|
||
```Gen
|
||
episode: AmpaOpen
|
||
contained_by: BEH-POST-AMPA
|
||
|
||
in_context: NtCapured
|
||
rf: ( active: 1x )
|
||
|
||
hypothesis: NOT (Ca2+ full)
|
||
action: [Ca2+ increase]
|
||
trace: None # Se Ca+FULLNESS, lascio tracce di overflow per modulazione DOWN, da capire UP
|
||
```
|
||
|
||
### Depolarization by bAP
|
||
|
||
Da ricordare i Dendritic VCGG che si aprono facendo entrare Ca2+ all'arrivo di bAP. In teoria abbiamo 3 Ion Channel.
|
||
|
||
- Timing: > 1 ms
|
||
- InContext: bAP backpropagating action potential
|
||
- Consequence: addition to local depolarization (EPSP) from bAP
|
||
|
||
### Mg²⁺ NMDA unblock
|
||
|
||
- Timing: > 1 ms
|
||
- InContext: local depolarization (EPSP) > FULLNESS (requires depolarization > -40mV)
|
||
- OutContext: NMDA Mg²⁺ unblock
|
||
|
||
### Full Ca+ influx by NDMA
|
||
|
||
- Timing: < 1 ms
|
||
- InContext: NMDA Mg²⁺ unblock
|
||
- Consequence: Na⁺ influx
|
||
- Consequence: addition to local depolarization (EPSP) from Full NMDA activation
|
||
|
||
### Upregulation: Observable
|
||
|
||
- Upregulation: Depolarization relieves NMDA Mg²⁺ block → Ca²⁺ influx amplification
|
||
|
||
### Downregulation: Observable
|
||
|
||
- Downregulation: AMPA desensitization acts as low-pass filter
|