329 lines
7.2 KiB
Markdown
329 lines
7.2 KiB
Markdown
# postsynapse.md
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Qui comprendiamo:
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- POSTSYNAPSE: Postsynapse
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- POST-AMPA: AMPA receptors (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors)
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## POSTSYNAPSE: Container
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**Simplified Behaviors**:
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— ms:
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- NT arrives in cleft → AMPA receptors bind NT (receptor availability constant, no desensitization)
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- V_post rises with AMPA conductance, decays passively each ms
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- bAP arrives → V_post receives additional depolarisation boost
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- NMDA gate checks coincidence: NT_cleft AND V_post both non-zero
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- Mg_block_removal = V_post / (V_post + V_NMDA_half) — sigmoid of V_post
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- Ca²⁺ enters spine via NMDA: Ca_post += k_NMDA × NT_cleft × Mg_block_removal
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- Ca_post decays slowly each ms (single exponential, no pump detail)
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- Ca_post_history updated every ms (feeds seconds loop)
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- V_post_history updated every ms (retained for reference)
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— seconds:
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- Ca_post_history mean computed over past 2 s
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- eCB synthesised when Ca_post_history mean exceeds eCB threshold
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- eCB_level decays when Ca_post_history mean falls below threshold
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- eCB_level written → read by presynapse as retrograde brake on VGCCs
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- Ca_post_history compared to LTP/LTD thresholds → plasticity tag set
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— mins:
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- If Plasticity_LTP tagged → AMPA density increases
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- If Plasticity_LTD tagged → AMPA density decreases
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- AMPA density feeds back into receptor_conductance ceiling for next cycle
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---
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**G expression**:
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```Gen
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POSTSYNAPSE
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bAP_ctx
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ms
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-- Ca Influx
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CaNDMAEnterMax: ( active: 2x )
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CaNDMAEnterMed: ( active: 4x )
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NOT bAP_ctx:
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ms
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-- Ca Influx
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CaNDMAEnterMedNotBap: ( active: 4x )
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CaNDMAEnterLow: ( active: 12x )
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-- Ca Clearence
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CaClearance: ( active: 24x ) # Low
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-- V Influx
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VPostMax: accumulator
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VPostMed: accumulator
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VPostLow: accumulator
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-- V Clearence
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VPostClearance: accumulator
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POST-AMPA
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NOT bAP_ctx
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ms
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-- Na Influx
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NaAMPAEnterMax: ( active: 2x )
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NaAMPAEnterMed: ( active: 4x )
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POST-NA-CLEAR
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NOT bAP_ctx
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ms
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-- Na Clearence
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NaClearanceHigh: accumulator
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NaClearanceLow: accumulator
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TUN-POST-AMPA
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TunPossible_ctx
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sec
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CheckTunPostAmpa: ( active: 60x )
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TryTunUpPostAmpa_ctx
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sec
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PossibleUpPostAmpaTun: ( active: 10x )
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TryTunDownPostAmpa_ctx
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sec
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PossibleDownPostAmpaTun: ( active: 10x )
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```
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**Tubs:**
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- **Na**: Ioni entranti tramite AMPA receptors
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- **NT**:
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- **Ca2+**: Ioni entranti tramite NMDA
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- **VPost**: il voltage che viene sentito in DB
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- **eCB**:
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- **Nox**:?
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---
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```Gen
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POSTSYNAPSE
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type: container
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expansion:
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- POST-AMPA ( full: 10x, active: 5x, empty: 2x )
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# modulated_by: TUN-POST-IC # possible/actual
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- POST-NA-CLEAR ( full: 1x, active: 1x, empty: 0x )
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# modulated_by: ??
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tub_local:
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- Ca2+ ( full: 60x, active: 30x, empty: 0x )
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- Na ( full: 60x, active: 30x, empty: 0x )
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- Nox ( full: 100x, active: 20x, empty: 0x ) # Nitric Oxide (NO): A gas that diffuses freely.
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- eCB ( full: 100x, active: 20x, empty: 0x ) # Endocannabinoids (e.g., 2-AG)
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tub_intricated:
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- NT ( contained_by: SYNAPSE )
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- VPost ( contained_by: BD )
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context_intricated:
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- bAp_ctx ( contained_by: SOMA )
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```
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### ms: behaviors POST
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##### CaNDMAEnterMax: accumulator
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```Gen
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CaNDMAEnterMax: ( active: 2x )
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type: accumulator
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contained_by: POSTSYNAPSE
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in_context: bAp_ctx
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hypothesis: NOT (Ca2+ full) AND
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(Na fullness OR Na mediumness)
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action: [Ca2+ increase]
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trace:
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```
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##### CaNDMAEnterMed: accumulator
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```Gen
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CaNDMAEnterMed: ( active: 4x )
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type: accumulator
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contained_by: POSTSYNAPSE
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in_context: bAp_ctx
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hypothesis: NOT (Ca2+ full) AND (Na emptiness)
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action: [Ca2+ increase]
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trace:
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```
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##### CaNDMAEnterMedNotBap: accumulator
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```Gen
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CaNDMAEnterMedNotBap: ( active: 4x )
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type: accumulator
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contained_by: POSTSYNAPSE
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in_context: NOT bAP_ctx
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hypothesis: NOT (Ca2+ full) AND (Na fullness)
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action: [Ca2+ increase]
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trace:
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```
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##### CaNDMAEnterLow: accumulator
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```Gen
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CaNDMAEnterLow: ( active: 12x )
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type: accumulator
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contained_by: POSTSYNAPSE
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in_context: NOT bAP_ctx
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hypothesis: NOT (Ca2+ full) AND (Na mediumness)
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action: [Ca2+ increase]
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trace:
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```
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#### CaClearance: accumulator
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```Gen
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CaClearance: ( active: 24x ) # Low
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type: accumulator
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contained_by: POSTSYNAPSE
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in_context: NOT bAP_ctx
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hypothesis: NOT (Ca2+ empty)
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action: [Ca2+ decrease]
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trace: None
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```
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##### VPostMax: accumulator
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##### VPostMed: accumulator
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##### VPostMin: accumulator
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##### VPostClearance: accumulator
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Il clearance lo facciamo qui nel container dove creaiamo anche i VPost, perche' altrimenti, se lo facessimo in DB, perderemmo l'aspetto temporale della contribuzione dei singoli POST.
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## POST-AMPA: Container
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```Gen
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POST-AMPA
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type: container
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tub_intricated:
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- NT ( contained_by: ASTROCYTE/SYNAPSE )
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context_intricated:
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- Na ( contained_by: POSTSYNAPSE )
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```
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### ms: behaviors AMPA
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##### NaAMPAEnterMax: accumulator
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```Gen
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NaAMPAEnterMax: ( active: 2x )
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type: accumulator
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contained_by: POST-AMPA
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in_context: NOT bAP_ctx
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hypothesis: (NT fullness)
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action: [Na increase]
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trace:
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```
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##### NaAMPAEnterMed: accumulator
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```Gen
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NaAMPAEnterMed: ( active: 4x )
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type: accumulator
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contained_by: POST-AMPA
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in_context: NOT bAP_ctx
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hypothesis: (NT mediumness)
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action: [Na increase]
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trace:
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```
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## POST-NA-CLEAR: Container
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Il clearance lo mettiamo qui come container, perche' gli AMPA creano, e questo container pompa fuori. Qui non e' un problema di perdere l'integrazione temporale, perche' gli AMPA sono tutti uguali nel loro behavior. Abbiamo messo gli AMPA come container perche' cosi' possiamo modularne la numerosita'.
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```Gen
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POST-NA-CLEAR
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type: container
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context_intricated:
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- Na ( contained_by: POSTSYNAPSE )
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```
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### ms: behaviors NA-CLEAR
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#### NaClearanceHigh: Interacting
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#### NaClearanceLow: Interacting
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#### TUN-POST-AMPA: Tuner
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```Gen
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TUN-POST-AMPA
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type: tuner
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contained_by: BEH-POST
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tunes: BEH-POST/expansion/BEH-POST-IC
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tub_modulation: # in TUN agiamo su POS/ACT
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- posMod ( fullness: None, active: BEH-POST-IC/fullness, empty: 0x) # riferimento a possible di BEH-PRE
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- actMod ( fullness: None, active: BEH-POST-IC/active, empty: BEH-POST-IC/emptiness) # riferimento a active di BEH-PRE
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context_intricated:
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- TunPossible ( contained_by: DAY-N )
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tub_local:
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tub_intricated:
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```
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##### CheckTunPostAmpa: contextor
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```Gen
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CheckTunPostAmpa: ( active: 60x )
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type: contextor
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contained_by: TUN-POST-AMPA
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in_context: TunPossible_ctx
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condition: tbd1
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out_context: TryTunUpPostAmpa_ctx
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condition: tbd2
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out_context: TryTunDownPostAmpa_ctx
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```
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##### PossibleUpPostAmpaTun: accumulator
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```Gen
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PossibleUpPostAmpaTun: ( active: 10x )
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type: accumulator
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contained_by: TUN-POST-AMPA
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in_context: TryTunUpPostAmpa_ctx
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hypothesis:
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action:
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trace:
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```
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##### PossibleDownPostAmpaTun: accumulator
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```Gen
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PossibleDownPostAmpaTun: ( active: 10x )
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type: accumulator
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contained_by: TUN-POST-AMPA
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in_context: TryTunDownPostAmpa_ctx
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hypothesis:
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action:
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trace:
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```
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