119 lines
3.0 KiB
Markdown
119 lines
3.0 KiB
Markdown
# BEH-AXO.md
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Qui comprendiamo:
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- BEH-BD: Dendritic Branch
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- BEH-POST: Postsynapsis
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- BEH-POST-AMPA: AMPA receptors (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors)
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## BEH-BD: Container
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**Dendritic Branch**: In questa prima fase, non consideriamo lo spike dendritico come comportamento. Questo limita molto il modello, perche' equipara tutte le Postsinapsi sui tre branch dendritici e non permette di fare in maniera che ad esempio due branch contestualizzino (base activity) e uno faccia scattare il threshold per lo spike somatico.
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Qui BEH-DB espande solo i BEH-POST, e' un cavo di collegamento come l'assone
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```Gen
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Container: BEH-BD
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expansion:
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- BEH-POST ( fullness: 50x, active: 20x, emptiness: 10x )
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# modulated_by: TUN-SYN-BD-POST possible/actual
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```
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## BEH-POST: Container
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```Gen
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container: BEH-POST
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expansion:
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- BEH-POST-AMPA ( fullness: 10x, active: 5x, emptiness: 2x )
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# modulated_by: TUN-POST-IC # possible/actual
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tub_local:
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- Ca2+ ( fullness: 60x, active: 30x, emptiness: 0x )
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# modulated_by: DEV-POST-???-FULL # Full
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- Nox ( fullness: 100x, active: 20x, emptiness: 0x ) # Nitric Oxide (NO): A gas that diffuses freely.
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- Ecb ( fullness: 100x, active: 20x, emptiness: 0x ) # Endocannabinoids (e.g., 2-AG)
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tub_intricated:
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- Nt ( contained_by: BEH-SYN )
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- bAp ( contained_by: BEH-SOMA )
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```
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### Context
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```Gen
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context: captureNt
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contained_by: BEH-POST
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in_context: Fixed
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rf: ( active: 10x )
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condition: (Nt full) AND NOT (bAp)
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out_context: NtCaptured
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```
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### Episode
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## BEH-POST-AMPA: Container
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```Gen
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container: BEH-POST-AMPA
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tub_intricated:
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- Nt ( contained_by: BEH-SYN )
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context_intricated:
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- bAp ( contained_by: BEH-SOMA )
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```
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### AmpaOpen: Episode
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- Timing: < 1 ms
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- InContext: Glutamate > FULLNESS
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- OutContext: AMPA receptor opening
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- Consequence: Na⁺ influx
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- Consequence: addition to local depolarization (EPSP) from AMPA activation
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```Gen
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episode: AmpaOpen
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contained_by: BEH-POST-AMPA
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in_context: NtCapured
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rf: ( active: 1x )
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hypothesis: NOT (Ca2+ full)
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action: [Ca2+ increase]
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trace: None # Se Ca+FULLNESS, lascio tracce di overflow per modulazione DOWN, da capire UP
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```
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### Depolarization by bAP
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Da ricordare i Dendritic VCGG che si aprono facendo entrare Ca2+ all'arrivo di bAP. In teoria abbiamo 3 Ion Channel.
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- Timing: > 1 ms
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- InContext: bAP backpropagating action potential
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- Consequence: addition to local depolarization (EPSP) from bAP
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### Mg²⁺ NMDA unblock
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- Timing: > 1 ms
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- InContext: local depolarization (EPSP) > FULLNESS (requires depolarization > -40mV)
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- OutContext: NMDA Mg²⁺ unblock
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### Full Ca+ influx by NDMA
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- Timing: < 1 ms
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- InContext: NMDA Mg²⁺ unblock
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- Consequence: Na⁺ influx
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- Consequence: addition to local depolarization (EPSP) from Full NMDA activation
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### Upregulation: Observable
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- Upregulation: Depolarization relieves NMDA Mg²⁺ block → Ca²⁺ influx amplification
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### Downregulation: Observable
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- Downregulation: AMPA desensitization acts as low-pass filter
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