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Update 2026-01-01-pre-post-atrocyte-timing.md

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ocrampal
2026-06-01 18:29:01 +02:00
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# Multi-Timescale Neural Component Analysis # Multi-Timescale Neural Component Analysis
## PRESYNAPSE ## PRESYNAPSE
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**Actions:** **Actions:**
- Vesicle docking and priming (SNARE complex assembly) - Vesicle docking and priming (SNARE complex assembly)
- Ca²⁺ influx - Ca²⁺ influx.
- Glutamate vesicle release (stochastic, probability P_r) - Glutamate vesicle release (stochastic, probability P_r)
**Outgoing Signals:** **Outgoing Signals:**
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3. **The astrocyte is the multi-scale bridge:** Operates at every timescale from milliseconds (glutamate clearance) to lifetime (metabolic support for epigenetics) 3. **The astrocyte is the multi-scale bridge:** Operates at every timescale from milliseconds (glutamate clearance) to lifetime (metabolic support for epigenetics)
4. **No component operates in isolation:** Each receives inputs from multiple timescales and sends outputs that affect multiple timescales 4. **No component operates in isolation:** Each receives inputs from multiple timescales and sends outputs that affect multiple timescales
5. **Modulation is contextual:** The "same" signal (e.g., Ca²⁺ influx) has different effects depending on metabolic state, recent history, neuromodulatory tone, and structural configuration 5. **Modulation is contextual:** The "same" signal (e.g., Ca²⁺ influx) has different effects depending on metabolic state, recent history, neuromodulatory tone, and structural configuration
6. **Metabolic veto is real:** Components can refuse to execute operations if metabolic resources are insufficient—this is not a bug but a feature of biological computation 6. **Metabolic veto is real:** Components can refuse to execute operations if metabolic resources are insufficient—this is not a bug but a feature of biological computation