From fca49d3b93015d85efd25aaa79f07de097767633 Mon Sep 17 00:00:00 2001 From: ocrampal Date: Mon, 1 Jun 2026 18:29:01 +0200 Subject: [PATCH] Update 2026-01-01-pre-post-atrocyte-timing.md --- .../appunti/2026-01-01-pre-post-atrocyte-timing.md | 8 ++++++-- 1 file changed, 6 insertions(+), 2 deletions(-) diff --git a/elements/astrocyte/appunti/2026-01-01-pre-post-atrocyte-timing.md b/elements/astrocyte/appunti/2026-01-01-pre-post-atrocyte-timing.md index dd35eeb..cbb6667 100644 --- a/elements/astrocyte/appunti/2026-01-01-pre-post-atrocyte-timing.md +++ b/elements/astrocyte/appunti/2026-01-01-pre-post-atrocyte-timing.md @@ -1,3 +1,7 @@ +--- +include_toc: true +--- + # Multi-Timescale Neural Component Analysis ## PRESYNAPSE @@ -12,7 +16,7 @@ **Actions:** - Vesicle docking and priming (SNARE complex assembly) -- Ca²⁺ influx +- Ca²⁺ influx. - Glutamate vesicle release (stochastic, probability P_r) **Outgoing Signals:** @@ -813,4 +817,4 @@ This active clearance happens rapidly, within tens to hundreds of milliseconds. 3. **The astrocyte is the multi-scale bridge:** Operates at every timescale from milliseconds (glutamate clearance) to lifetime (metabolic support for epigenetics) 4. **No component operates in isolation:** Each receives inputs from multiple timescales and sends outputs that affect multiple timescales 5. **Modulation is contextual:** The "same" signal (e.g., Ca²⁺ influx) has different effects depending on metabolic state, recent history, neuromodulatory tone, and structural configuration -6. **Metabolic veto is real:** Components can refuse to execute operations if metabolic resources are insufficient—this is not a bug but a feature of biological computation \ No newline at end of file +6. **Metabolic veto is real:** Components can refuse to execute operations if metabolic resources are insufficient—this is not a bug but a feature of biological computation