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Update elements/neuron/presynapse.md

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Sergio Marchetti
2026-05-30 12:58:39 +02:00
parent a89de909d9
commit f55ed02efd
1 changed files with 112 additions and 98 deletions
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elements/neuron/presynapse.md
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@@ -13,7 +13,6 @@ Qui comprendiamo:
```Gen ```Gen
PRESYNAPSE PRESYNAPSE
type: comprehension type: comprehension
expansion: expansion:
@@ -24,21 +23,23 @@ PRESYNAPSE
intrication: intrication:
# Scope # Scope
!DAY: INTRICATION [ ref: &ORGANISM.!DAY] !DAY: INTRICATION [ ref: &ORGANISM.!DAY ]
!NIGHT: INTRICATION [ ref: &ORGANISM.!NIGHT] !NIGHT: INTRICATION [ ref: &ORGANISM.!NIGHT ]
# Context # Context
*AP: INTRICATION [ ref: &SOMA.*AP] *AP: INTRICATION [ ref: &SOMA.*AP ]
*TunePossible: INTRICATION [ref: &...] # To be defined... *TunePossible: INTRICATION [ ref: &... ] # To be defined...
# Tub # Tub
_NT: INTRICATION [ ref: &ASTROSYNAPSE._NT] _NT: INTRICATION [ ref: &ASTROSYNAPSE._NT ]
_ATP: INTRICATION [ ref: &ASTROCYTE._ATP] _ATP: INTRICATION [ ref: &ASTROCYTE._ATP ]
_eCB: INTRICATION [ ref: &POSTSYNAPSE._eCB] _eCB: INTRICATION [ ref: &POSTSYNAPSE._eCB ]
instantiation: instantiation:
# Context # Context
*TryTunUpPreVcgg: CONTEXT []
*TryTunDownPreVcgg: CONTEXT []
# Tub # Tub
_Ca2: TUB [ full: 60x, active: 30x, empty: 0x ] _Ca2: TUB [ full: 60x, active: 30x, empty: 0x ]
@@ -68,24 +69,24 @@ MAIN_PRE
snippet: snippet:
# *AP # *AP
@: ACCUMULATOR [snippet: NTreleaseLow, RF: active 12x] @: ACCUMULATOR [ snippet: NTreleaseLow, rf: active 12x ]
@: ACCUMULATOR [snippet: NTreleaseMedium, RF: active 9x] @: ACCUMULATOR [ snippet: NTreleaseMedium, rf: active 9x ]
@: ACCUMULATOR [snippet: NTreleaseHigh, RF: active 6x] @: ACCUMULATOR [ snippet: NTreleaseHigh, rf: active 6x ]
@: ACCUMULATOR [snippet: TracesAccLow, RF: active 3x] @: ACCUMULATOR [ snippet: TracesAccLow, rf: active 3x ]
@: ACCUMULATOR [snippet: TracesAccMedium, RF: active 6x] @: ACCUMULATOR [ snippet: TracesAccMedium, rf: active 6x ]
@: ACCUMULATOR [snippet: TracesAccHigh, RF: active 10x] @: ACCUMULATOR [ snippet: TracesAccHigh, rf: active 10x ]
# NOT *AP # NOT *AP
@: ACCUMULATOR [snippet: eCBClearenceMedium, RF: active 24x] @: ACCUMULATOR [ snippet: eCBClearenceMedium, rf: active 24x ]
@: ACCUMULATOR [snippet: eCBClearenceLow, RF: active 48x] @: ACCUMULATOR [ snippet: eCBClearenceLow, rf: active 48x ]
@: ACCUMULATOR [snippet: RPShuttleLow, RF: active 24x] @: ACCUMULATOR [ snippet: RPShuttleLow, rf: active 24x ]
@: ACCUMULATOR [snippet: RPShuttleMedium, RF: active 48x] @: ACCUMULATOR [ snippet: RPShuttleMedium, rf: active 48x ]
@: ACCUMULATOR [snippet: RefillGlutamine, RF: active 24x] @: ACCUMULATOR [ snippet: RefillGlutamine, rf: active 24x ]
@: ACCUMULATOR [snippet: TracesClearance, RF: active 30x] @: ACCUMULATOR [ snippet: TracesClearance, rf: active 30x ]
``` ```
**Tubs:** **Tubs:**
@@ -119,11 +120,12 @@ In tutti i casi di NT
```Gen ```Gen
NTreleaseLow NTreleaseLow
type: accumulator
in_context: *AP in_context: *AP
hypothesis: _Ca2 mediumness AND _Rrp mediumness AND NOT _ATP empty hypothesis: _Ca2 mediumness AND _Rrp mediumness AND NOT _ATP empty
action: [_Rrp decrease, _NT increase, _ATP decrease] action: [ _Rrp decrease, _NT increase, _ATP decrease ]
trace: None trace: None
``` ```
@@ -131,13 +133,14 @@ NTreleaseLow
```Gen ```Gen
NTreleaseMedium NTreleaseMedium
type: accumulator
in_context: *AP in_context: *AP
hypothesis: ( _Ca2 fullness AND _Rrp mediumness ) OR hypothesis: ( _Ca2 fullness AND _Rrp mediumness ) OR
( _Ca2 mediumness AND _Rrp fullness ) AND ( _Ca2 mediumness AND _Rrp fullness ) AND
NOT _ATP empty NOT _ATP empty
action: [_Rrp decrease, _NT increase, _ATP decrease] action: [ _Rrp decrease, _NT increase, _ATP decrease ]
trace: None trace: None
``` ```
@@ -145,12 +148,13 @@ NTreleaseMedium
```Gen ```Gen
NTreleaseHigh NTreleaseHigh
type: accumulator
in_context: *AP in_context: *AP
hypothesis: ( _Ca2 fullness AND _Rrp fullness ) AND hypothesis: _Ca2 fullness AND _Rrp fullness AND
NOT _ATP empty NOT _ATP empty
action: [_Rrp decrease, NT increase, _ATP decrease] action: [ _Rrp decrease, NT increase, _ATP decrease ]
trace: None trace: None
``` ```
@@ -168,8 +172,9 @@ Serve a:
```Gen ```Gen
Ca2TracesAccuLow Ca2TracesAccuLow
type: accumulator
in_context: *AP in_context: *AP
hypothesis: _Ca2 emptiness hypothesis: _Ca2 emptiness
action: [ _CaTraceLow increase ] action: [ _CaTraceLow increase ]
@@ -180,8 +185,9 @@ Ca2TracesAccuLow
```Gen ```Gen
Ca2TracesAccMedium Ca2TracesAccMedium
type: accumulator
in_context: *AP in_context: *AP
hypothesis: _Ca2 mediumness hypothesis: _Ca2 mediumness
action: [ _CaTraceMed increase ] action: [ _CaTraceMed increase ]
@@ -192,8 +198,9 @@ Ca2TracesAccMedium
```Gen ```Gen
Ca2TracesAccumulationHigh Ca2TracesAccumulationHigh
type: accumulator
in_context: *AP in_context: *AP
hypothesis: _Ca2 fullness hypothesis: _Ca2 fullness
action: [ _CaTraceHigh increase ] action: [ _CaTraceHigh increase ]
@@ -210,8 +217,9 @@ Qui non facciamo un flush di eCB, riduciamo ogni mezzo secondo (context) di un R
```Gen ```Gen
eCBClearance: ( active: 24x ) # Slow eCBClearance: ( active: 24x ) # Slow
type: accumulator
in_context: NOT *AP in_context: NOT *AP
hypothesis: NOT _eCB empty hypothesis: NOT _eCB empty
action: [ _eCB decrease ] action: [ _eCB decrease ]
@@ -228,13 +236,14 @@ Rate: 0.00 – 0.25
```Gen ```Gen
RPShuttleLow RPShuttleLow
type: accumulator
in_context: NOT *AP in_context: NOT *AP
hypothesis: _CaTraceLow fullness OR hypothesis: _CaTraceLow fullness OR
_RP emptiness OR _RP emptiness OR
_Rrp fullness _Rrp fullness
action: [RP decrease, _Rrp increase] action: [ _RP decrease, _Rrp increase ]
trace: None trace: None
``` ```
@@ -246,14 +255,15 @@ Rate: 0.50 – 0.97
```Gen ```Gen
RPShuttleMedium RPShuttleMedium
type: accumulator
in_context: *AP in_context: *AP
hypothesis: ( _CaTraceMedium fullness AND _RP mediumness AND _Rrp mediumness ) OR hypothesis: ( _CaTraceMedium fullness AND _RP mediumness AND _Rrp mediumness ) OR
( _CaTraceHigh fullness AND _RP mediumness AND _Rrp mediumness ) OR # signal boost ( _CaTraceHigh fullness AND _RP mediumness AND _Rrp mediumness ) OR # signal boost
( _CaTraceMedium fullness AND _RP fullness AND _Rrp mediumness ) OR # supply boost ( _CaTraceMedium fullness AND _RP fullness AND _Rrp mediumness ) OR # supply boost
( _CaTraceMedium fullness AND _RP mediumness AND _Rrp emptiness ) # vacancy boost ( _CaTraceMedium fullness AND _RP mediumness AND _Rrp emptiness ) # vacancy boost
action: [RP decrease, _Rrp increase] action: [ _RP decrease, _Rrp increase ]
trace: None trace: None
``` ```
@@ -265,13 +275,14 @@ Rate: 1.25 – 1.94
```Gen ```Gen
RPShuttleHigh RPShuttleHigh
type: accumulator
in_context: *AP in_context: *AP
hypothesis: ( _CaTraceHigh fullness AND _RP fullness AND _Rrp mediumness ) OR # signal + supply hypothesis: ( _CaTraceHigh fullness AND _RP fullness AND _Rrp mediumness ) OR # signal + supply
( _CaTraceHigh fullness AND _RP mediumness AND _Rrp emptiness ) OR # signal + vacancy ( _CaTraceHigh fullness AND _RP mediumness AND _Rrp emptiness ) OR # signal + vacancy
( _CaTraceMedium fullness AND _RP fullness AND _Rrp emptiness ) # supply + vacancy ( _CaTraceMedium fullness AND _RP fullness AND _Rrp emptiness ) # supply + vacancy
action: [ _RP decrease, _Rrp increase] action: [ _RP decrease, _Rrp increase ]
trace: None trace: None
``` ```
@@ -311,8 +322,9 @@ Qui facciamo un flush di CaTraceX. Deve essere fatto a valle del tuning.
```Gen ```Gen
Ca2TracesClearance Ca2TracesClearance
type: accumulator
in_context: NOT *TunePossible in_context: NOT *TunePossible
hypothesis: NOT _CaTraceHigh empty hypothesis: NOT _CaTraceHigh empty
action: [ _CaTRaceHigh decrease ] action: [ _CaTRaceHigh decrease ]
@@ -333,32 +345,21 @@ Ca2TracesClearance
TUNE_VGCC_PRE TUNE_VGCC_PRE
type: behaviour type: behaviour
# qui stiamo aggiungendo o eliminando VGCC_PRE. Fra un massimo full e minimo empty (empty puo' non essere 0) # qui stiamo aggiungendo o eliminando VGCC_PRE. Fra un massimo full e minimo empty (empty puo' non essere 0)
# contained_by: PRESYNAPSE non e' contenuto, si attacca. # contained_by: PRESYNAPSE non e' contenuto, si attacca.
activity_scope: !DAY activity_scope: !DAY
context_intricated:
- *TunePossible ( contained_by: DAY-N )
tub_passed:
_VgccPre: TUB [pass.@VGCC_PRE]
tub_local:
tub_intricated:
snippet: snippet:
# *TunePossible # *TunePossible
CheckVgccPreTun: CONTEXTOR [RF: active 60x] @: CONTEXTOR [ snippet: CheckVgccPreTun, rf: active 60x ]
*TryTunUpPreVcgg # *TryTunUpPreVcgg
PossibleUpPreVgccTun: ACCUMULATOR [RF:active 10x] @: ACCUMULATOR [ snippet: PossibleUpPreVgccTun, rf:active 10x ]
*TryTunDownPreVcgg # *TryTunDownPreVcgg
PossibleDownPreVgccTun: ACCUMULATOR [RF:active 10x] @: ACCUMULATOR [ snippet: PossibleDownPreVgccTun, rf:active 10x ]
``` ```
#### *TunePossible #### *TunePossible
@@ -369,13 +370,14 @@ Qui controlliamo che ci siano le condizioni per aumentare o diminuire la quantit
```Gen ```Gen
CheckVgccPreTun CheckVgccPreTun
type contextor
in_context: *TunePossible
in_context: *TunePossible condition: _CaTraceHigh fullness
condition: ( CaTraceHigh fullness )
out_context: *TryTunUpPreVcgg out_context: *TryTunUpPreVcgg
condition: ( CaTraceLow fullness ) condition: _CaTraceLow fullness
out_context: *TryTunDownPreVcgg out_context: *TryTunDownPreVcgg
``` ```
@@ -383,8 +385,9 @@ CheckVgccPreTun
```Gen ```Gen
PossibleUpPreVgccTun PossibleUpPreVgccTun
type: accumulator
in_context: TryTunUpPreVcgg_ctx in_context: *TryTunUpPreVcgg
hypothesis: hypothesis:
action: action:
@@ -395,8 +398,9 @@ PossibleUpPreVgccTun
```Gen ```Gen
PossibleDownPreVgccTun PossibleDownPreVgccTun
type: accumulator
in_context: TryTunDownPreVcgg_ctx in_context: *TryTunDownPreVcgg
hypothesis: hypothesis:
action: action:
@@ -409,10 +413,21 @@ Voltage-Controlled Gated Channels: Qui per ora non gestiamo l'evoluzione della d
```Gen ```Gen
VGCC-PRE VGCC-PRE
type: comprehension type: comprehension
instantiate_behaviour: # Scope
BEHAVIOR_VGCC_PRE: behaviour [] !DAY: INTRICATION [ ref: &ORGANISM.!DAY ]
!NIGHT: INTRICATION [ ref: &ORGANISM.!NIGHT ]
# Context
*AP: INTRICATION [ ref: &SOMA.*AP ]
# Tub
_NT: INTRICATION [ ref: &ASTROSYNAPSE._NT ]
_Ca2: INTRICATION [ ref: &PRESYNAPSE._Ca2 ]
# Behaviour
@: BEHAVIOUR [ behaviour: VGCC_PRE_BEH ]
``` ```
### BEHAVIOR_VGCC_PRE ### BEHAVIOR_VGCC_PRE
@@ -420,26 +435,20 @@ instantiate_behaviour:
Voltage-Controlled Gated Channels: Qui per ora non gestiamo l'evoluzione della depolarizzazione. Alla scomparsa dell'AP, i VGCC smettono di funzionare. Voltage-Controlled Gated Channels: Qui per ora non gestiamo l'evoluzione della depolarizzazione. Alla scomparsa dell'AP, i VGCC smettono di funzionare.
```Gen ```Gen
BEHAVIOR_VGCC_PRE VGCC_PRE_BEH
activity_scope: !DAY
type: behaviour type: behaviour
tub_intricated: within_scope: !DAY
- _Ca2 ( contained_by: PRESYNAPSE-BHE )
- NT ( contained_by: SYN )
context_intricated:
- AP ( contained_by: SOMA )
snippets: snippets:
# *AP
@: ACCUMULATOR [ snippet: Ca2enterLow, rf: active 12x ]
@: ACCUMULATOR [ snippet: Ca2enterMedium, rf: active 6x ]
@: ACCUMULATOR [ snippet: Ca2enterHigh, rf: active 3x ]
Ca2enterLow: ACCUMULATOR [RF: active 12x] # NOT *AP
Ca2enterMedium: ACCUMULATOR [RF: active 6x] @: ACCUMULATOR [ snippet: Ca2ClearanceLow, rf: active 24x ]
Ca2enterHigh: ACCUMULATOR [RF: active 3x] @: ACCUMULATOR [ snippet: Ca2ClearanceHigh, rf: active 4x ]
Ca2ClearanceLow: ACCUMULATOR [RF: active 24x]
Ca2ClearanceHigh: ACCUMULATOR [RF: active 4x]
``` ```
@@ -469,11 +478,12 @@ Devo controllare che le condizioni sotto siano esaustive. Qui ho confuso high co
```Gen ```Gen
Ca2enterLow Ca2enterLow
type: accumulator
in_context: *AP in_context: *AP
hypothesis: (_Ca2 empty) AND (eCB empty) hypothesis: _Ca2 empty AND _eCB empty
action: [_Ca2 increase, _ATP decrease] action: [ _Ca2 increase, _ATP decrease ]
trace: None trace: None
``` ```
@@ -481,13 +491,14 @@ Ca2enterLow
```Gen ```Gen
Ca2enterMedium Ca2enterMedium
type: accumulator
in_context: *AP in_context: *AP
hypothesis: (_Ca2 mediumness) OR hypothesis: _Ca2 mediumness OR
((eCB mediumness) AND (_Ca2 empty)) OR ( _eCB mediumness AND _Ca2 empty ) OR
((eCB full) AND (_Ca2 empty) AND (NT empty)) ( _eCB full AND _Ca2 empty AND _NT empty )
action: [_Ca2 increase, _ATP decrease] action: [ _Ca2 increase, _ATP decrease ]
trace: None trace: None
``` ```
@@ -495,12 +506,13 @@ Ca2enterMedium
```Gen ```Gen
Ca2enterHigh Ca2enterHigh
type: accumulator
in_context: *AP in_context: *AP
hypothesis: (_Ca2 mediumness) AND (eCB full) OR hypothesis: ( _Ca2 mediumness AND _eCB full ) OR
(eCB mediumness) _eCB mediumness
action: [_Ca2 increase, _ATP decrease] action: [ _Ca2 increase, _ATP decrease ]
trace: None trace: None
``` ```
@@ -524,11 +536,12 @@ Qui disinguiamo:
```Gen ```Gen
Ca2ClearanceLow Ca2ClearanceLow
type: accumulator
in_context: NOT *AP in_context: NOT *AP
hypothesis: (NOT _Ca2 fullness) AND (NOT _Ca2 empty) hypothesis: NOT _Ca2 fullness AND NOT _Ca2 empty
action: [_Ca2 decrease] action: [ _Ca2 decrease ]
trace: None trace: None
``` ```
@@ -536,10 +549,11 @@ Ca2ClearanceLow
```Gen ```Gen
Ca2ClearanceHigh Ca2ClearanceHigh
type: accumulator
in_context: NOT *AP in_context: NOT *AP
hypothesis: NOT (Ca2 empty) hypothesis: NOT _Ca2 empty
action: [Ca2 decrease] action: [Ca2 decrease]
trace: None trace: None
``` ```