Update elements/neuron/presynapse.md
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+112
-98
@@ -13,7 +13,6 @@ Qui comprendiamo:
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```Gen
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PRESYNAPSE
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type: comprehension
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expansion:
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@@ -24,21 +23,23 @@ PRESYNAPSE
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intrication:
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# Scope
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!DAY: INTRICATION [ ref: &ORGANISM.!DAY]
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!NIGHT: INTRICATION [ ref: &ORGANISM.!NIGHT]
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!DAY: INTRICATION [ ref: &ORGANISM.!DAY ]
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!NIGHT: INTRICATION [ ref: &ORGANISM.!NIGHT ]
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# Context
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*AP: INTRICATION [ ref: &SOMA.*AP]
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*TunePossible: INTRICATION [ref: &...] # To be defined...
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*AP: INTRICATION [ ref: &SOMA.*AP ]
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*TunePossible: INTRICATION [ ref: &... ] # To be defined...
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# Tub
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_NT: INTRICATION [ ref: &ASTROSYNAPSE._NT]
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_ATP: INTRICATION [ ref: &ASTROCYTE._ATP]
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_eCB: INTRICATION [ ref: &POSTSYNAPSE._eCB]
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_NT: INTRICATION [ ref: &ASTROSYNAPSE._NT ]
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_ATP: INTRICATION [ ref: &ASTROCYTE._ATP ]
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_eCB: INTRICATION [ ref: &POSTSYNAPSE._eCB ]
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instantiation:
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# Context
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*TryTunUpPreVcgg: CONTEXT []
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*TryTunDownPreVcgg: CONTEXT []
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# Tub
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_Ca2: TUB [ full: 60x, active: 30x, empty: 0x ]
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@@ -68,24 +69,24 @@ MAIN_PRE
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snippet:
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# *AP
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@: ACCUMULATOR [snippet: NTreleaseLow, RF: active 12x]
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@: ACCUMULATOR [snippet: NTreleaseMedium, RF: active 9x]
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@: ACCUMULATOR [snippet: NTreleaseHigh, RF: active 6x]
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@: ACCUMULATOR [ snippet: NTreleaseLow, rf: active 12x ]
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@: ACCUMULATOR [ snippet: NTreleaseMedium, rf: active 9x ]
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@: ACCUMULATOR [ snippet: NTreleaseHigh, rf: active 6x ]
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@: ACCUMULATOR [snippet: TracesAccLow, RF: active 3x]
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@: ACCUMULATOR [snippet: TracesAccMedium, RF: active 6x]
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@: ACCUMULATOR [snippet: TracesAccHigh, RF: active 10x]
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@: ACCUMULATOR [ snippet: TracesAccLow, rf: active 3x ]
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@: ACCUMULATOR [ snippet: TracesAccMedium, rf: active 6x ]
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@: ACCUMULATOR [ snippet: TracesAccHigh, rf: active 10x ]
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# NOT *AP
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@: ACCUMULATOR [snippet: eCBClearenceMedium, RF: active 24x]
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@: ACCUMULATOR [snippet: eCBClearenceLow, RF: active 48x]
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@: ACCUMULATOR [ snippet: eCBClearenceMedium, rf: active 24x ]
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@: ACCUMULATOR [ snippet: eCBClearenceLow, rf: active 48x ]
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@: ACCUMULATOR [snippet: RPShuttleLow, RF: active 24x]
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@: ACCUMULATOR [snippet: RPShuttleMedium, RF: active 48x]
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@: ACCUMULATOR [ snippet: RPShuttleLow, rf: active 24x ]
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@: ACCUMULATOR [ snippet: RPShuttleMedium, rf: active 48x ]
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@: ACCUMULATOR [snippet: RefillGlutamine, RF: active 24x]
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@: ACCUMULATOR [ snippet: RefillGlutamine, rf: active 24x ]
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@: ACCUMULATOR [snippet: TracesClearance, RF: active 30x]
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@: ACCUMULATOR [ snippet: TracesClearance, rf: active 30x ]
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```
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**Tubs:**
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@@ -119,11 +120,12 @@ In tutti i casi di NT
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```Gen
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NTreleaseLow
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type: accumulator
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in_context: *AP
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in_context: *AP
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hypothesis: _Ca2 mediumness AND _Rrp mediumness AND NOT _ATP empty
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action: [_Rrp decrease, _NT increase, _ATP decrease]
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hypothesis: _Ca2 mediumness AND _Rrp mediumness AND NOT _ATP empty
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action: [ _Rrp decrease, _NT increase, _ATP decrease ]
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trace: None
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```
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@@ -131,13 +133,14 @@ NTreleaseLow
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```Gen
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NTreleaseMedium
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type: accumulator
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in_context: *AP
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in_context: *AP
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hypothesis: ( _Ca2 fullness AND _Rrp mediumness ) OR
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( _Ca2 mediumness AND _Rrp fullness ) AND
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NOT _ATP empty
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action: [_Rrp decrease, _NT increase, _ATP decrease]
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action: [ _Rrp decrease, _NT increase, _ATP decrease ]
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trace: None
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```
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@@ -145,12 +148,13 @@ NTreleaseMedium
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```Gen
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NTreleaseHigh
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type: accumulator
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in_context: *AP
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in_context: *AP
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hypothesis: ( _Ca2 fullness AND _Rrp fullness ) AND
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NOT _ATP empty
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action: [_Rrp decrease, NT increase, _ATP decrease]
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hypothesis: _Ca2 fullness AND _Rrp fullness AND
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NOT _ATP empty
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action: [ _Rrp decrease, NT increase, _ATP decrease ]
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trace: None
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```
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@@ -168,8 +172,9 @@ Serve a:
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```Gen
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Ca2TracesAccuLow
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type: accumulator
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in_context: *AP
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in_context: *AP
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hypothesis: _Ca2 emptiness
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action: [ _CaTraceLow increase ]
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@@ -180,8 +185,9 @@ Ca2TracesAccuLow
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```Gen
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Ca2TracesAccMedium
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type: accumulator
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in_context: *AP
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in_context: *AP
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hypothesis: _Ca2 mediumness
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action: [ _CaTraceMed increase ]
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@@ -192,8 +198,9 @@ Ca2TracesAccMedium
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```Gen
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Ca2TracesAccumulationHigh
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type: accumulator
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in_context: *AP
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in_context: *AP
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hypothesis: _Ca2 fullness
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action: [ _CaTraceHigh increase ]
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@@ -210,8 +217,9 @@ Qui non facciamo un flush di eCB, riduciamo ogni mezzo secondo (context) di un R
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```Gen
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eCBClearance: ( active: 24x ) # Slow
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type: accumulator
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in_context: NOT *AP
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in_context: NOT *AP
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hypothesis: NOT _eCB empty
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action: [ _eCB decrease ]
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@@ -228,13 +236,14 @@ Rate: 0.00 – 0.25
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```Gen
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RPShuttleLow
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type: accumulator
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in_context: NOT *AP
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in_context: NOT *AP
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hypothesis: _CaTraceLow fullness OR
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_RP emptiness OR
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_Rrp fullness
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action: [RP decrease, _Rrp increase]
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action: [ _RP decrease, _Rrp increase ]
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trace: None
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```
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@@ -246,14 +255,15 @@ Rate: 0.50 – 0.97
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```Gen
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RPShuttleMedium
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type: accumulator
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in_context: *AP
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in_context: *AP
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hypothesis: ( _CaTraceMedium fullness AND _RP mediumness AND _Rrp mediumness ) OR
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( _CaTraceHigh fullness AND _RP mediumness AND _Rrp mediumness ) OR # signal boost
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( _CaTraceMedium fullness AND _RP fullness AND _Rrp mediumness ) OR # supply boost
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( _CaTraceMedium fullness AND _RP mediumness AND _Rrp emptiness ) # vacancy boost
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action: [RP decrease, _Rrp increase]
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action: [ _RP decrease, _Rrp increase ]
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trace: None
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```
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@@ -265,13 +275,14 @@ Rate: 1.25 – 1.94
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```Gen
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RPShuttleHigh
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type: accumulator
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in_context: *AP
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in_context: *AP
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hypothesis: ( _CaTraceHigh fullness AND _RP fullness AND _Rrp mediumness ) OR # signal + supply
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( _CaTraceHigh fullness AND _RP mediumness AND _Rrp emptiness ) OR # signal + vacancy
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( _CaTraceMedium fullness AND _RP fullness AND _Rrp emptiness ) # supply + vacancy
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action: [ _RP decrease, _Rrp increase]
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action: [ _RP decrease, _Rrp increase ]
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trace: None
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```
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@@ -311,8 +322,9 @@ Qui facciamo un flush di CaTraceX. Deve essere fatto a valle del tuning.
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```Gen
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Ca2TracesClearance
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type: accumulator
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in_context: NOT *TunePossible
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in_context: NOT *TunePossible
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hypothesis: NOT _CaTraceHigh empty
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action: [ _CaTRaceHigh decrease ]
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@@ -333,32 +345,21 @@ Ca2TracesClearance
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TUNE_VGCC_PRE
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type: behaviour
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# qui stiamo aggiungendo o eliminando VGCC_PRE. Fra un massimo full e minimo empty (empty puo' non essere 0)
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# contained_by: PRESYNAPSE non e' contenuto, si attacca.
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activity_scope: !DAY
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context_intricated:
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- *TunePossible ( contained_by: DAY-N )
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tub_passed:
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_VgccPre: TUB [pass.@VGCC_PRE]
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tub_local:
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tub_intricated:
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snippet:
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# *TunePossible
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CheckVgccPreTun: CONTEXTOR [RF: active 60x]
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@: CONTEXTOR [ snippet: CheckVgccPreTun, rf: active 60x ]
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*TryTunUpPreVcgg
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PossibleUpPreVgccTun: ACCUMULATOR [RF:active 10x]
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# *TryTunUpPreVcgg
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@: ACCUMULATOR [ snippet: PossibleUpPreVgccTun, rf:active 10x ]
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*TryTunDownPreVcgg
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PossibleDownPreVgccTun: ACCUMULATOR [RF:active 10x]
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# *TryTunDownPreVcgg
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@: ACCUMULATOR [ snippet: PossibleDownPreVgccTun, rf:active 10x ]
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```
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#### *TunePossible
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@@ -369,13 +370,14 @@ Qui controlliamo che ci siano le condizioni per aumentare o diminuire la quantit
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```Gen
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CheckVgccPreTun
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type contextor
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in_context: *TunePossible
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in_context: *TunePossible
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condition: ( CaTraceHigh fullness )
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condition: _CaTraceHigh fullness
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out_context: *TryTunUpPreVcgg
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condition: ( CaTraceLow fullness )
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condition: _CaTraceLow fullness
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out_context: *TryTunDownPreVcgg
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```
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@@ -383,8 +385,9 @@ CheckVgccPreTun
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```Gen
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PossibleUpPreVgccTun
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type: accumulator
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in_context: TryTunUpPreVcgg_ctx
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in_context: *TryTunUpPreVcgg
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hypothesis:
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action:
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@@ -395,8 +398,9 @@ PossibleUpPreVgccTun
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```Gen
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PossibleDownPreVgccTun
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type: accumulator
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in_context: TryTunDownPreVcgg_ctx
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in_context: *TryTunDownPreVcgg
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hypothesis:
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action:
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@@ -409,10 +413,21 @@ Voltage-Controlled Gated Channels: Qui per ora non gestiamo l'evoluzione della d
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```Gen
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VGCC-PRE
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type: comprehension
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type: comprehension
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instantiate_behaviour:
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BEHAVIOR_VGCC_PRE: behaviour []
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# Scope
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!DAY: INTRICATION [ ref: &ORGANISM.!DAY ]
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!NIGHT: INTRICATION [ ref: &ORGANISM.!NIGHT ]
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# Context
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*AP: INTRICATION [ ref: &SOMA.*AP ]
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# Tub
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_NT: INTRICATION [ ref: &ASTROSYNAPSE._NT ]
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_Ca2: INTRICATION [ ref: &PRESYNAPSE._Ca2 ]
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# Behaviour
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@: BEHAVIOUR [ behaviour: VGCC_PRE_BEH ]
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```
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### BEHAVIOR_VGCC_PRE
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@@ -420,26 +435,20 @@ instantiate_behaviour:
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Voltage-Controlled Gated Channels: Qui per ora non gestiamo l'evoluzione della depolarizzazione. Alla scomparsa dell'AP, i VGCC smettono di funzionare.
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```Gen
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BEHAVIOR_VGCC_PRE
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activity_scope: !DAY
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VGCC_PRE_BEH
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type: behaviour
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tub_intricated:
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- _Ca2 ( contained_by: PRESYNAPSE-BHE )
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- NT ( contained_by: SYN )
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context_intricated:
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- AP ( contained_by: SOMA )
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within_scope: !DAY
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snippets:
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# *AP
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@: ACCUMULATOR [ snippet: Ca2enterLow, rf: active 12x ]
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@: ACCUMULATOR [ snippet: Ca2enterMedium, rf: active 6x ]
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@: ACCUMULATOR [ snippet: Ca2enterHigh, rf: active 3x ]
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Ca2enterLow: ACCUMULATOR [RF: active 12x]
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Ca2enterMedium: ACCUMULATOR [RF: active 6x]
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Ca2enterHigh: ACCUMULATOR [RF: active 3x]
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Ca2ClearanceLow: ACCUMULATOR [RF: active 24x]
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Ca2ClearanceHigh: ACCUMULATOR [RF: active 4x]
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# NOT *AP
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@: ACCUMULATOR [ snippet: Ca2ClearanceLow, rf: active 24x ]
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@: ACCUMULATOR [ snippet: Ca2ClearanceHigh, rf: active 4x ]
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```
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@@ -469,11 +478,12 @@ Devo controllare che le condizioni sotto siano esaustive. Qui ho confuso high co
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```Gen
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Ca2enterLow
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type: accumulator
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in_context: *AP
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in_context: *AP
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hypothesis: (_Ca2 empty) AND (eCB empty)
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action: [_Ca2 increase, _ATP decrease]
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hypothesis: _Ca2 empty AND _eCB empty
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action: [ _Ca2 increase, _ATP decrease ]
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trace: None
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```
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@@ -481,13 +491,14 @@ Ca2enterLow
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```Gen
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Ca2enterMedium
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type: accumulator
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in_context: *AP
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in_context: *AP
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hypothesis: (_Ca2 mediumness) OR
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((eCB mediumness) AND (_Ca2 empty)) OR
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((eCB full) AND (_Ca2 empty) AND (NT empty))
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action: [_Ca2 increase, _ATP decrease]
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hypothesis: _Ca2 mediumness OR
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( _eCB mediumness AND _Ca2 empty ) OR
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( _eCB full AND _Ca2 empty AND _NT empty )
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action: [ _Ca2 increase, _ATP decrease ]
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trace: None
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```
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@@ -495,12 +506,13 @@ Ca2enterMedium
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```Gen
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Ca2enterHigh
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type: accumulator
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in_context: *AP
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in_context: *AP
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hypothesis: (_Ca2 mediumness) AND (eCB full) OR
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(eCB mediumness)
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action: [_Ca2 increase, _ATP decrease]
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hypothesis: ( _Ca2 mediumness AND _eCB full ) OR
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_eCB mediumness
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action: [ _Ca2 increase, _ATP decrease ]
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trace: None
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```
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@@ -524,11 +536,12 @@ Qui disinguiamo:
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```Gen
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Ca2ClearanceLow
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type: accumulator
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in_context: NOT *AP
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in_context: NOT *AP
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hypothesis: (NOT _Ca2 fullness) AND (NOT _Ca2 empty)
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action: [_Ca2 decrease]
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hypothesis: NOT _Ca2 fullness AND NOT _Ca2 empty
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action: [ _Ca2 decrease ]
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trace: None
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```
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@@ -536,10 +549,11 @@ Ca2ClearanceLow
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```Gen
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Ca2ClearanceHigh
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type: accumulator
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in_context: NOT *AP
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in_context: NOT *AP
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hypothesis: NOT (Ca2 empty)
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hypothesis: NOT _Ca2 empty
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action: [Ca2 decrease]
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trace: None
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```
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Reference in New Issue
Block a user