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ocrampal
2026-03-09 09:04:14 +01:00
parent ce5a115332
commit dd70834ef2
3 changed files with 41 additions and 41 deletions
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astrocyte/TUN-AST.md
+11 -11
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@@ -8,26 +8,25 @@ La novita' e' lo SCOPE, nel quale avviene il ragionamento.
## TUN-AST: Modulator
...
Trattandosi di creazione e distruzione di syn, forse deve andare in DEV-TUN?
```Gen
modulator: TUN-AST
contained_by: AREA1
contained_by: AST
modulates: BEH-AXO/expansion/BEH-PRE
#
tub_modulation: #
- prePossible ( N/BEH-AXO/BEH-PRE/possible )
- preActual ( N/BEH-AXO/BEH-PRE/actual )
- postPossible ( N/BEH-BD/BEH-POST/possible )
- postActual ( N/BEH-BD/BEH-POST/actual )
- synPossible ( AST/BEH-AST/SYN/actual )
- synActual ( AST/BEH-AST/SYN/actual )
tub_scope: synapse
- preAst ( +[N/BEH-AXO/BEH-PRE] )
- postAst ( +[N/BEH-BD/BEH-POST] )
# qui vanno tutte le pre e post che fanno capo ad una Asta nella dichiarazione di relazione fatta in WTA
tub_local:
- ??? (fullness: 50x, active: 0x, emptiness: 0x)
# intricated with ???
tub_intricated:
- syn (indef, indef, 0x) # dichiarazione in BEH-AST
```
Forse con questi tub_modulation riesco a risolvere il problema dello SCOPE, perche' mi servono a mettere assieme scope diversi, quelli di PRE, POST e SYN.
@@ -37,7 +36,7 @@ Forse con questi tub_modulation riesco a risolvere il problema dello SCOPE, perc
....
```Gen
context: ???
context: Fixed
contained_by: TUN-AST
in_context: Fixed
@@ -58,6 +57,7 @@ episode: activate
in_context: ???
rf: ( active: 6x )
scope: synapse
hypothesis: NOT (?? empty)
action: [??? decrease]
trace: None
neuron/BEH-AXO.md
+20 -20
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@@ -14,7 +14,7 @@ Qui comprendiamo:
container: BEH-AXO
expansion:
- BEH-PRE ( fullness: 50x, active: 20x, emptiness: 10x )
- BEH-PRE ( fullness: 50x, active: 0x, emptiness: 10x )
# modulated_by: TUN-SYN-AXO-PRE# possible/actual
```
@@ -26,20 +26,20 @@ container: BEH-AXO
- Ca2+: Calcium Ion entering the Presynapse when VCGG open. They are key to check the concentration, release vescicles and modulation
- Rrp: Readily Releasable Pool
The Readily Releasable Pool consists of the vesicles that are "docked" and "primed" at the active zone of the synapse.
Location: Directly touching the presynaptic membrane.
Function: These are the first to be released when an action potential arrives.
Characteristics: This pool is very small (usually only about 0.5% to 5% of total vesicles) and can be exhausted quickly during high-frequency firing, leading to "short-term depression" of the signal.
The Readily Releasable Pool consists of the vesicles that are "docked" and "primed" at the active zone of the synapse.
Location: Directly touching the presynaptic membrane.
Function: These are the first to be released when an action potential arrives.
Characteristics: This pool is very small (usually only about 0.5% to 5% of total vesicles) and can be exhausted quickly during high-frequency firing, leading to "short-term depression" of the signal.
- RecP: Recycling Pool
The Recycling Pool is the next line of reinforcement.
Location: Slightly further back from the membrane than the RRP.
Function: These vesicles maintain release during moderate, physiological levels of stimulation.
Characteristics: They are continuously refilled as the neuron "recycles" the membranes of used vesicles through endocytosis. This pool is larger than the RRP (roughly 5% to 20% of the total).
The Recycling Pool is the next line of reinforcement.
Location: Slightly further back from the membrane than the RRP.
Function: These vesicles maintain release during moderate, physiological levels of stimulation.
Characteristics: They are continuously refilled as the neuron "recycles" the membranes of used vesicles through endocytosis. This pool is larger than the RRP (roughly 5% to 20% of the total).
- Rp: The "Reserve Pool" (The true RP)
In many textbooks, RP specifically stands for the Reserve Pool.
Location: The bulk of the vesicles held further back in the terminal, often tethered by a protein called synapsin.
Function: These are only mobilized during intense, prolonged stimulation once the RRP and Recycling pools are depleted.
Characteristics: This makes up the vast majority of the vesicles (up to 80% or 90%).
In many textbooks, RP specifically stands for the Reserve Pool.
Location: The bulk of the vesicles held further back in the terminal, often tethered by a protein called synapsin.
Function: These are only mobilized during intense, prolonged stimulation once the RRP and Recycling pools are depleted.
Characteristics: This makes up the vast majority of the vesicles (up to 80% or 90%).
- Nt: Neuro Transmitter, released in the synapse by the vescicles
- TagRelease: forse non serve, ma indica il rilascio di NT da parte di una syn.
@@ -47,15 +47,15 @@ Characteristics: This makes up the vast majority of the vesicles (up to 80% or 9
L'idea e' che:
- Fast
-- i VCGG si aprano all'arrivo di un AP dal SOMA. Il numero dei VCGG presenti e' stato modulato (TUN) in una fase di non attivita' della presynapse
-- I VCGG fanno entrare Ca2+ che ne aumenta la concentrazione
-- ad un certo livello di concentrazione, viene liberata una vescica, se ci sono Rrp disponibili. La vescica libera xxx Nt nella sinsapsi
-- i VCGG si aprano all'arrivo di un AP dal SOMA. Il numero dei VCGG presenti e' stato modulato (TUN) in una fase di non attivita' della presynapse
-- I VCGG fanno entrare Ca2+ che ne aumenta la concentrazione
-- ad un certo livello di concentrazione, viene liberata una vescica, se ci sono Rrp disponibili. La vescica libera xxx Nt nella sinsapsi
- Medium
-- clearance dei Ca2+ che depolarizza la Presinapsi
-- riciclo delle vesciche, prendendole dalla Sinapsi e mettenedole dentro a RecP
-- clearance dei Ca2+ che depolarizza la Presinapsi
-- riciclo delle vesciche, prendendole dalla Sinapsi e mettenedole dentro a RecP
- Slow
-- riempimento vesciche di Nt e mettendole dentro Rp
-- spostamento da Rp a RecP
-- riempimento vesciche di Nt e mettendole dentro Rp
-- spostamento da Rp a RecP
```Gen
container: BEH-PRE
winnertakeall/BEH-WTA.md
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@@ -54,6 +54,6 @@ L'espansione:
In questo modo abbiamo allargato il concetto di espansione introducendo una sorta di spazialita', che dipende dalla relazione che viene imposta, e puo' essere verifica.
Problemi da risolver:
- posso permettere che una PRE e POST dello stesso N possano fare sinapsi.
- Non posso permettere che una PRE e POST dello stesso N possano fare sinapsi.
- INH e EXH ora espongono il modulo WTA ad un'area cerebrale dove viene specificato l'intricazione fra moduli, e AST che fa la modulazione
- posso pensare di produrre il circuito in ambiente visuale tipo DrawIO, e avere un parser che me lo trasforma in questa sintassi.