diff --git a/astrocyte/TUN-AST.md b/astrocyte/TUN-AST.md index 2e9de45..b949a69 100644 --- a/astrocyte/TUN-AST.md +++ b/astrocyte/TUN-AST.md @@ -8,26 +8,25 @@ La novita' e' lo SCOPE, nel quale avviene il ragionamento. ## TUN-AST: Modulator -... +Trattandosi di creazione e distruzione di syn, forse deve andare in DEV-TUN? ```Gen modulator: TUN-AST - contained_by: AREA1 + contained_by: AST modulates: BEH-AXO/expansion/BEH-PRE # - tub_modulation: # - - prePossible ( N/BEH-AXO/BEH-PRE/possible ) - - preActual ( N/BEH-AXO/BEH-PRE/actual ) - - postPossible ( N/BEH-BD/BEH-POST/possible ) - - postActual ( N/BEH-BD/BEH-POST/actual ) - - synPossible ( AST/BEH-AST/SYN/actual ) - - synActual ( AST/BEH-AST/SYN/actual ) + tub_scope: synapse + - preAst ( +[N/BEH-AXO/BEH-PRE] ) + - postAst ( +[N/BEH-BD/BEH-POST] ) + # qui vanno tutte le pre e post che fanno capo ad una Asta nella dichiarazione di relazione fatta in WTA tub_local: - ??? (fullness: 50x, active: 0x, emptiness: 0x) - # intricated with ??? + + tub_intricated: + - syn (indef, indef, 0x) # dichiarazione in BEH-AST ``` Forse con questi tub_modulation riesco a risolvere il problema dello SCOPE, perche' mi servono a mettere assieme scope diversi, quelli di PRE, POST e SYN. @@ -37,7 +36,7 @@ Forse con questi tub_modulation riesco a risolvere il problema dello SCOPE, perc .... ```Gen -context: ??? +context: Fixed contained_by: TUN-AST in_context: Fixed @@ -58,7 +57,8 @@ episode: activate in_context: ??? rf: ( active: 6x ) - hypothesis: NOT (?? empty) - action: [??? decrease] - trace: None + scope: synapse + hypothesis: NOT (?? empty) + action: [??? decrease] + trace: None ``` diff --git a/neuron/BEH-AXO.md b/neuron/BEH-AXO.md index d36eb43..f620719 100644 --- a/neuron/BEH-AXO.md +++ b/neuron/BEH-AXO.md @@ -14,7 +14,7 @@ Qui comprendiamo: container: BEH-AXO expansion: - - BEH-PRE ( fullness: 50x, active: 20x, emptiness: 10x ) + - BEH-PRE ( fullness: 50x, active: 0x, emptiness: 10x ) # modulated_by: TUN-SYN-AXO-PRE# possible/actual ``` @@ -25,37 +25,37 @@ container: BEH-AXO **Tubs:** - Ca2+: Calcium Ion entering the Presynapse when VCGG open. They are key to check the concentration, release vescicles and modulation -- Rrp: Readily Releasable Pool -The Readily Releasable Pool consists of the vesicles that are "docked" and "primed" at the active zone of the synapse. -Location: Directly touching the presynaptic membrane. -Function: These are the first to be released when an action potential arrives. -Characteristics: This pool is very small (usually only about 0.5% to 5% of total vesicles) and can be exhausted quickly during high-frequency firing, leading to "short-term depression" of the signal. -- RecP: Recycling Pool -The Recycling Pool is the next line of reinforcement. -Location: Slightly further back from the membrane than the RRP. -Function: These vesicles maintain release during moderate, physiological levels of stimulation. -Characteristics: They are continuously refilled as the neuron "recycles" the membranes of used vesicles through endocytosis. This pool is larger than the RRP (roughly 5% to 20% of the total). -- Rp: The "Reserve Pool" (The true RP) -In many textbooks, RP specifically stands for the Reserve Pool. -Location: The bulk of the vesicles held further back in the terminal, often tethered by a protein called synapsin. -Function: These are only mobilized during intense, prolonged stimulation once the RRP and Recycling pools are depleted. -Characteristics: This makes up the vast majority of the vesicles (up to 80% or 90%). +- Rrp: Readily Releasable Pool + The Readily Releasable Pool consists of the vesicles that are "docked" and "primed" at the active zone of the synapse. + Location: Directly touching the presynaptic membrane. + Function: These are the first to be released when an action potential arrives. + Characteristics: This pool is very small (usually only about 0.5% to 5% of total vesicles) and can be exhausted quickly during high-frequency firing, leading to "short-term depression" of the signal. +- RecP: Recycling Pool + The Recycling Pool is the next line of reinforcement. + Location: Slightly further back from the membrane than the RRP. + Function: These vesicles maintain release during moderate, physiological levels of stimulation. + Characteristics: They are continuously refilled as the neuron "recycles" the membranes of used vesicles through endocytosis. This pool is larger than the RRP (roughly 5% to 20% of the total). +- Rp: The "Reserve Pool" (The true RP) + In many textbooks, RP specifically stands for the Reserve Pool. + Location: The bulk of the vesicles held further back in the terminal, often tethered by a protein called synapsin. + Function: These are only mobilized during intense, prolonged stimulation once the RRP and Recycling pools are depleted. + Characteristics: This makes up the vast majority of the vesicles (up to 80% or 90%). - Nt: Neuro Transmitter, released in the synapse by the vescicles - TagRelease: forse non serve, ma indica il rilascio di NT da parte di una syn. **Behaviors**: L'idea e' che: -- Fast --- i VCGG si aprano all'arrivo di un AP dal SOMA. Il numero dei VCGG presenti e' stato modulato (TUN) in una fase di non attivita' della presynapse --- I VCGG fanno entrare Ca2+ che ne aumenta la concentrazione --- ad un certo livello di concentrazione, viene liberata una vescica, se ci sono Rrp disponibili. La vescica libera xxx Nt nella sinsapsi -- Medium --- clearance dei Ca2+ che depolarizza la Presinapsi --- riciclo delle vesciche, prendendole dalla Sinapsi e mettenedole dentro a RecP -- Slow --- riempimento vesciche di Nt e mettendole dentro Rp --- spostamento da Rp a RecP +- Fast + -- i VCGG si aprano all'arrivo di un AP dal SOMA. Il numero dei VCGG presenti e' stato modulato (TUN) in una fase di non attivita' della presynapse + -- I VCGG fanno entrare Ca2+ che ne aumenta la concentrazione + -- ad un certo livello di concentrazione, viene liberata una vescica, se ci sono Rrp disponibili. La vescica libera xxx Nt nella sinsapsi +- Medium + -- clearance dei Ca2+ che depolarizza la Presinapsi + -- riciclo delle vesciche, prendendole dalla Sinapsi e mettenedole dentro a RecP +- Slow + -- riempimento vesciche di Nt e mettendole dentro Rp + -- spostamento da Rp a RecP ```Gen container: BEH-PRE diff --git a/winnertakeall/BEH-WTA.md b/winnertakeall/BEH-WTA.md index 2264e63..1385879 100644 --- a/winnertakeall/BEH-WTA.md +++ b/winnertakeall/BEH-WTA.md @@ -54,6 +54,6 @@ L'espansione: In questo modo abbiamo allargato il concetto di espansione introducendo una sorta di spazialita', che dipende dalla relazione che viene imposta, e puo' essere verifica. Problemi da risolver: -- posso permettere che una PRE e POST dello stesso N possano fare sinapsi. +- Non posso permettere che una PRE e POST dello stesso N possano fare sinapsi. - INH e EXH ora espongono il modulo WTA ad un'area cerebrale dove viene specificato l'intricazione fra moduli, e AST che fa la modulazione - posso pensare di produrre il circuito in ambiente visuale tipo DrawIO, e avere un parser che me lo trasforma in questa sintassi.