lint
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+26
-26
@@ -14,7 +14,7 @@ Qui comprendiamo:
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container: BEH-AXO
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expansion:
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- BEH-PRE ( fullness: 50x, active: 20x, emptiness: 10x )
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- BEH-PRE ( fullness: 50x, active: 0x, emptiness: 10x )
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# modulated_by: TUN-SYN-AXO-PRE# possible/actual
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```
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@@ -25,37 +25,37 @@ container: BEH-AXO
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**Tubs:**
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- Ca2+: Calcium Ion entering the Presynapse when VCGG open. They are key to check the concentration, release vescicles and modulation
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- Rrp: Readily Releasable Pool
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The Readily Releasable Pool consists of the vesicles that are "docked" and "primed" at the active zone of the synapse.
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Location: Directly touching the presynaptic membrane.
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Function: These are the first to be released when an action potential arrives.
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Characteristics: This pool is very small (usually only about 0.5% to 5% of total vesicles) and can be exhausted quickly during high-frequency firing, leading to "short-term depression" of the signal.
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- RecP: Recycling Pool
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The Recycling Pool is the next line of reinforcement.
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Location: Slightly further back from the membrane than the RRP.
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Function: These vesicles maintain release during moderate, physiological levels of stimulation.
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Characteristics: They are continuously refilled as the neuron "recycles" the membranes of used vesicles through endocytosis. This pool is larger than the RRP (roughly 5% to 20% of the total).
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- Rp: The "Reserve Pool" (The true RP)
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In many textbooks, RP specifically stands for the Reserve Pool.
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Location: The bulk of the vesicles held further back in the terminal, often tethered by a protein called synapsin.
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Function: These are only mobilized during intense, prolonged stimulation once the RRP and Recycling pools are depleted.
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Characteristics: This makes up the vast majority of the vesicles (up to 80% or 90%).
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- Rrp: Readily Releasable Pool
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The Readily Releasable Pool consists of the vesicles that are "docked" and "primed" at the active zone of the synapse.
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Location: Directly touching the presynaptic membrane.
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Function: These are the first to be released when an action potential arrives.
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Characteristics: This pool is very small (usually only about 0.5% to 5% of total vesicles) and can be exhausted quickly during high-frequency firing, leading to "short-term depression" of the signal.
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- RecP: Recycling Pool
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The Recycling Pool is the next line of reinforcement.
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Location: Slightly further back from the membrane than the RRP.
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Function: These vesicles maintain release during moderate, physiological levels of stimulation.
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Characteristics: They are continuously refilled as the neuron "recycles" the membranes of used vesicles through endocytosis. This pool is larger than the RRP (roughly 5% to 20% of the total).
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- Rp: The "Reserve Pool" (The true RP)
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In many textbooks, RP specifically stands for the Reserve Pool.
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Location: The bulk of the vesicles held further back in the terminal, often tethered by a protein called synapsin.
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Function: These are only mobilized during intense, prolonged stimulation once the RRP and Recycling pools are depleted.
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Characteristics: This makes up the vast majority of the vesicles (up to 80% or 90%).
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- Nt: Neuro Transmitter, released in the synapse by the vescicles
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- TagRelease: forse non serve, ma indica il rilascio di NT da parte di una syn.
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**Behaviors**:
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L'idea e' che:
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- Fast
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-- i VCGG si aprano all'arrivo di un AP dal SOMA. Il numero dei VCGG presenti e' stato modulato (TUN) in una fase di non attivita' della presynapse
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-- I VCGG fanno entrare Ca2+ che ne aumenta la concentrazione
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-- ad un certo livello di concentrazione, viene liberata una vescica, se ci sono Rrp disponibili. La vescica libera xxx Nt nella sinsapsi
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- Medium
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-- clearance dei Ca2+ che depolarizza la Presinapsi
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-- riciclo delle vesciche, prendendole dalla Sinapsi e mettenedole dentro a RecP
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- Slow
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-- riempimento vesciche di Nt e mettendole dentro Rp
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-- spostamento da Rp a RecP
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- Fast
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-- i VCGG si aprano all'arrivo di un AP dal SOMA. Il numero dei VCGG presenti e' stato modulato (TUN) in una fase di non attivita' della presynapse
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-- I VCGG fanno entrare Ca2+ che ne aumenta la concentrazione
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-- ad un certo livello di concentrazione, viene liberata una vescica, se ci sono Rrp disponibili. La vescica libera xxx Nt nella sinsapsi
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- Medium
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-- clearance dei Ca2+ che depolarizza la Presinapsi
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-- riciclo delle vesciche, prendendole dalla Sinapsi e mettenedole dentro a RecP
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- Slow
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-- riempimento vesciche di Nt e mettendole dentro Rp
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-- spostamento da Rp a RecP
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```Gen
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container: BEH-PRE
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