change interacting
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-41
@@ -38,22 +38,27 @@ Qui comprendiamo:
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— ms:
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- Here the threshold is based only on the integration of Na+
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- The threshold is tuned during the spiketrain. Low threshold at rest, to increase sensitivity, threshold increase during spike to increase discrimination
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- based on VDB, VGSC open and let Na+ in. VGSG then go into refractory
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- if Na fullness then AP. Here the threshold is based only on the integration of Na+
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- increase SpikeTrainTraces (fast at spike)
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- increase Ca2+ traces
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- fast pump which decreases Na+, we do not model K+
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- must figure out how to deal with deoplarization
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- decrease Na: fast pump which decreases Na+, we do not model K+
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-- there is a tug of war between Na entering and exiting. Na can reach fullness only if VDB increases fast (derivative)
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- there are 2 context: AP and RefractorySoma imlemented with timers and tunable
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- decrease SpikeTraintraces slow, only if away from spiketrain this is empty
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- Tune:
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-- The threshold is tuned during the spiketrain. Low threshold at rest, to increase sensitivity, threshold increase during spike to increase discrimination
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— secs:
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- SpikeTrainTraces
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— mins:
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- Tune:
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-- refractory lenght
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---
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**Tubs:**
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@@ -100,17 +105,17 @@ container: SOMA
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### ms: SOMA
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#### CheckVDB: Context
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#### CheckVDB: Interacting
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As dendrites deliver current (VDB), the soma acts like a capacitor. It "stores" this charge in the form of membrane potential. This contextualizes VGSC-SOMA to open ion channels that let Na+ ions in.
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This only applies if not AP, or in other words, SOMA is not in refractory period.
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```Gen
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context: CheckVDB
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interacting: CheckVDB
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contained_by: SOMA
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in_context: Fixed
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context: Fixed
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rf: ( active: 60x )
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condition: (VDB fullness ) AND NOT AP
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@@ -123,47 +128,54 @@ context: CheckVDB
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out_context: VDBLow
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```
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#### CheckSomaSpike: Context
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#### CheckSomaSpike: Interacting
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The initiation and duration of a spike
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Qui siamo nella fase effettiva di spike, non refractory che viene dopo. Fa da contesto di durata fra un RF ed un altro.
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```Gen
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context: CheckSomaSpike
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interacting: CheckSomaSpike
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contained_by: SOMA
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in_context: Fixed
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context: Fixed
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rf: ( active: 60x )
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condition: ( Na fullness OR APRefractory )
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condition: ( Na fullness ) AND ( NOT SomaRefractory )
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out_context: AP
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out_context: bAP
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```
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#### SomaSpike: Episode
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#### APInteracting: Interacting
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Durante la fase effettiva di spike, eliminiamo Na accumulati e riempiamo per fase di refractory
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```Gen
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episode: SomaSpike
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interacting: APInteracting
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contained_by: SOMA
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in_context: AP
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context: AP
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rf: ( active: 8x )
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hypothesis:
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action:
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hypothesis: NOT Na empty
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action: [ decrease Na ]
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trace:
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hypothesis: NOT RefractorySoma full
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action: [ increase RefractorySoma ]
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trace:
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```
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#### ClearNa: Episode
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#### ClearRefractorySoma: Interacting
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```Gen
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episode: ClearNa
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interacting: ClearRefractorySoma
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contained_by: SOMA
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in_context: Fixed
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context: Fixed
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rf: ( active: 8x )
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hypothesis:
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action:
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hypothesis: NOT RefractorySoma empty
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action: [ decrease RefractorySoma ]
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trace:
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```
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@@ -194,20 +206,20 @@ tuner: VGSC-SOMA-TUN
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context: Check
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contained_by: VGSC-SOMA-TUN
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in_context: TunPossible
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context: TunPossible
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rf: ( active: 60x )
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condition:
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out_context: TunSomaVcgg
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```
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##### ?: Episode
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##### ?: Interacting
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```Gen
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episode: ?
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interacting: ?
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contained_by: TUN-PRE-VGCC
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in_context: TunSomaVcgg
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context: TunSomaVcgg
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rf: ( active: x )
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hypothesis:
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@@ -231,15 +243,15 @@ container: VGSC-SOMA-H
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### sec: VGSC-SOMA-H
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#### NaEnterH: Episode
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#### NaEnterH: Interacting
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Se metto il controllo sulla (NOT Ready fullness) il VGSC puo' far entrare un numero di Na non superiore ad un massimo.
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```Gen
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episode: NaEnterH
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interacting: NaEnterH
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contained_by: VGSC-H-SOMA
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in_context: VDBMax AND ( NOT RefractoryH )
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context: VDBMax AND ( NOT RefractoryH )
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rf: ( active: 1x )
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hypothesis: ( NOT Na fullness ) AND ( NOT ReadyH fullness )
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@@ -255,22 +267,22 @@ Il check su refractory deve essere fatto ad un RF maggiore della eliminazione di
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context: CheckRefractoryH
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contained_by: VGSC-H-SOMA
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in_context: NOT RefractoryH
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context: NOT RefractoryH
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rf: ( active: 60x )
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condition: ( ReadyH fullness )
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out_context: RefractoryH
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```
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##### RefractoryH: Episode
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##### RefractoryH: Interacting
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Questo episodio deve girare varie volte nell'ambito del contesto di refractory che viene controllato ad un RF maggiore.
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```Gen
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episode: RefractoryH
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interacting: RefractoryH
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contained_by: VGSC-H-SOMA
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in_context: RefractoryH
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context: RefractoryH
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rf: ( active: 1x )
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hypothesis: NOT ( Ready emptyness )
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@@ -289,13 +301,13 @@ container: VGSC-SOMA-M
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### sec: VGSC-SOMA-M
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#### Episode2
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#### Interacting2
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```Gen
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episode: ??
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interacting: ??
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contained_by: VGSC-M-SOMA
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in_context: xxx
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context: xxx
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rf: ( active: 1x )
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hypothesis:
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@@ -314,13 +326,13 @@ container: VGSC-SOMA-M
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### sec: VGSC-SOMA-L
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#### Episode3
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#### Interacting3
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```Gen
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episode: ??
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interacting: ??
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contained_by: VGSC-L-SOMA
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in_context: xxx
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context: xxx
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rf: ( active: 1x )
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hypothesis:
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