Edit presynapse.md

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Sergio Marchetti
2026-05-04 12:38:46 +00:00
parent 7a640c5c9d
commit c07abac82e
+20 -19
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@@ -246,6 +246,7 @@ NT empty. Qui siamo contestualizzati se Ca2+ full, il che dovrebbe significare i
In tutti i casi di NT In tutti i casi di NT
#### NTreleaseMedium: accumulator
```Gen ```Gen
NTreleaseLow: ( active: 12x ) # Low NTreleaseLow: ( active: 12x ) # Low
type: accumulator type: accumulator
@@ -257,7 +258,7 @@ NTreleaseLow: ( active: 12x ) # Low
trace: None trace: None
``` ```
#### NTreleaseMedium: int: ms #### NTreleaseMedium: accumulatorv
In tutti i casi di NT In tutti i casi di NT
@@ -274,7 +275,7 @@ NTreleaseMedium: ( active: 9x ) # Medium
trace: None trace: None
``` ```
#### NTreleaseHigh: int: ms #### NTreleaseHigh: accumulator
```Gen ```Gen
NTreleaseHigh: ( active: 3x ) # High NTreleaseHigh: ( active: 3x ) # High
@@ -288,7 +289,7 @@ NTreleaseHigh: ( active: 3x ) # High
trace: None trace: None
``` ```
#### Ca2+TracesAccumulationLow: int: ms #### Ca2+TracesAccumulationLow: accumulator
Serve a: Serve a:
- fare il tuning dei VGCC - fare il tuning dei VGCC
@@ -312,7 +313,7 @@ Ca2+TracesAccumulationLow: ( active: 10x )
trace: None trace: None
``` ```
#### Ca2+TracesAccumulationMedium: int: ms #### Ca2+TracesAccumulationMedium: accumulator
```Gen ```Gen
Ca2+TracesAccumulationMedium: ( active: 6x ) # medium Ca2+TracesAccumulationMedium: ( active: 6x ) # medium
@@ -325,7 +326,7 @@ Ca2+TracesAccumulationMedium: ( active: 6x ) # medium
trace: None trace: None
``` ```
#### Ca2+TracesAccumulationHigh: int: ms #### Ca2+TracesAccumulationHigh: accumulator
```Gen ```Gen
@@ -341,7 +342,7 @@ Ca2+TracesAccumulationHigh: ( active: 10x ) # high
### NOT AP_ctx: PRESYNAPSE ### NOT AP_ctx: PRESYNAPSE
#### eCB clearance: int: sec #### eCB clearance: accumulator
eCB dipende da POST. Tende a modulare l'entrata di Ca2+ degli VGCC. eCB dipende da POST. Tende a modulare l'entrata di Ca2+ degli VGCC.
@@ -358,7 +359,7 @@ eCBClearance: ( active: 24x ) # Slow
trace: None trace: None
``` ```
#### RPShuttleLow: int: sec #### RPShuttleLow: accumulator
This happens in the seconds loop, once per second. This happens in the seconds loop, once per second.
@@ -379,7 +380,7 @@ RPShuttleLow: ( active: 48x ) # Low
trace: None trace: None
``` ```
#### RPShuttleMedium: int: sec #### RPShuttleMedium: accumulatorv
The "Sub-Optimal" State. The machinery is working, but it's held back by partial limitations. This covers cases where the signal is steady but the "piston" isn't firing at full speed, or where a high vacancy in the RRP (emptiness) forces a low signal to work a bit harder. The "Sub-Optimal" State. The machinery is working, but it's held back by partial limitations. This covers cases where the signal is steady but the "piston" isn't firing at full speed, or where a high vacancy in the RRP (emptiness) forces a low signal to work a bit harder.
@@ -399,7 +400,7 @@ RPShuttleMedium: ( active: 24x ) # Medium
trace: None trace: None
``` ```
#### RPShuttleHigh: int: sec #### RPShuttleHigh: accumulator
The "High Performance" State. Multiple systems are optimized, but one is still at a "mediumness" level. This represents an active synapse that hasn't reached its absolute peak because either the supply is only 50% or the RRP isn't empty enough to create that "maximal vacuum" pull. The "High Performance" State. Multiple systems are optimized, but one is still at a "mediumness" level. This represents an active synapse that hasn't reached its absolute peak because either the supply is only 50% or the RRP isn't empty enough to create that "maximal vacuum" pull.
@@ -418,7 +419,7 @@ RPShuttleHigh: ( active: 12x ) # Fast
trace: None trace: None
``` ```
#### RefillRPGlutamine: int: min #### RefillRPGlutamine: accumulator
This happens in the minutes loop, once per minute, via the glutamine shuttle from the astrocyte. It is a two-step process across two cells. This happens in the minutes loop, once per minute, via the glutamine shuttle from the astrocyte. It is a two-step process across two cells.
@@ -450,7 +451,7 @@ Each tier buys time for the one below it to respond. When all three are depleted
### TunPossible_ctx: PRESYNAPSE ### TunPossible_ctx: PRESYNAPSE
#### Ca2+TracesClearance: int: sec #### Ca2+TracesClearance: accumulator
Qui facciamo un flush di CaTraceX. Deve essere fatto a valle del tuning. Qui facciamo un flush di CaTraceX. Deve essere fatto a valle del tuning.
@@ -493,7 +494,7 @@ VGCC-PRE
Da rivedere le condizioni per aggiungere mGluR che ha come proxy NT concentration!!!!! Da rivedere le condizioni per aggiungere mGluR che ha come proxy NT concentration!!!!!
#### Ca2+enterLow: int: ms #### Ca2+enterLow: accumulator
Here we comprehend the breaking activity on VGCC by: CDI, eCB and mGluR: Here we comprehend the breaking activity on VGCC by: CDI, eCB and mGluR:
@@ -524,7 +525,7 @@ Ca2+enterLow: ( active: 12x ) # Low
trace: None trace: None
``` ```
#### Ca2+enterMedium: int: ms #### Ca2+enterMedium: accumulator
```Gen ```Gen
Ca2+enterMedium: ( active: 6x ) # Medium Ca2+enterMedium: ( active: 6x ) # Medium
@@ -539,7 +540,7 @@ Ca2+enterMedium: ( active: 6x ) # Medium
trace: None trace: None
``` ```
#### Ca2+enterHigh: int: ms #### Ca2+enterHigh: accumulator
```Gen ```Gen
Ca2+enterHigh: ( active: 3x ) # High Ca2+enterHigh: ( active: 3x ) # High
@@ -555,7 +556,7 @@ Ca2+enterHigh: ( active: 3x ) # High
### NOT AP_ctx: VGCC-PRE ### NOT AP_ctx: VGCC-PRE
#### Ca2+ClearanceLow: int: ms #### Ca2+ClearanceLow: accumulator
Qui eliminiamo Ca2+. Il tempo che ci mette ad eliminare il Ca2+ dovrebbe essere minoe dell'inervallo fra un AP_ctx e un'altra. Siccome non comprendiamo per ora ATP, non c'e' accumulo di Ca2+ per mancanza di ATP (stanchezza). Qui eliminiamo Ca2+. Il tempo che ci mette ad eliminare il Ca2+ dovrebbe essere minoe dell'inervallo fra un AP_ctx e un'altra. Siccome non comprendiamo per ora ATP, non c'e' accumulo di Ca2+ per mancanza di ATP (stanchezza).
@@ -580,7 +581,7 @@ Ca2+ClearanceLow: ( active: 24x ) # Low
trace: None trace: None
``` ```
#### Ca2+ClearanceHigh: int: ms #### Ca2+ClearanceHigh: accumulator
```Gen ```Gen
Ca2+ClearanceHigh: ( active: 4x ) # High Ca2+ClearanceHigh: ( active: 4x ) # High
@@ -616,7 +617,7 @@ VGCC-PRE-TUN
### TunPossible_ctx: VGCC-PRE-TUN ### TunPossible_ctx: VGCC-PRE-TUN
#### CheckVgccPreTun: contexting: sec #### CheckVgccPreTun: contexting
Qui controlliamo che ci siano le condizioni per aumentare o diminuire la quantita' di VGCC Qui controlliamo che ci siano le condizioni per aumentare o diminuire la quantita' di VGCC
@@ -633,7 +634,7 @@ CheckVgccPreTun: ( active: 60x )
out_context: TryTunDownPreVcgg_ctx out_context: TryTunDownPreVcgg_ctx
``` ```
#### PossibleUpPreVgccTun: int: sec #### PossibleUpPreVgccTun: accumulator
```Gen ```Gen
PossibleUpPreVgccTun: ( active: 10x ) PossibleUpPreVgccTun: ( active: 10x )
@@ -646,7 +647,7 @@ PossibleUpPreVgccTun: ( active: 10x )
trace: trace:
``` ```
#### PossibleDownPreVgccTun: int: sec #### PossibleDownPreVgccTun: accumulator
```Gen ```Gen
PossibleDownPreVgccTun: ( active: 10x ) PossibleDownPreVgccTun: ( active: 10x )