From c07abac82ebec271ece610612528887fa5e3d59a Mon Sep 17 00:00:00 2001 From: Sergio Marchetti Date: Mon, 4 May 2026 12:38:46 +0000 Subject: [PATCH] Edit presynapse.md --- neuron/presynapse.md | 39 ++++++++++++++++++++------------------- 1 file changed, 20 insertions(+), 19 deletions(-) diff --git a/neuron/presynapse.md b/neuron/presynapse.md index b8a14da..76c90e7 100644 --- a/neuron/presynapse.md +++ b/neuron/presynapse.md @@ -246,6 +246,7 @@ NT empty. Qui siamo contestualizzati se Ca2+ full, il che dovrebbe significare i In tutti i casi di NT +#### NTreleaseMedium: accumulator ```Gen NTreleaseLow: ( active: 12x ) # Low type: accumulator @@ -257,7 +258,7 @@ NTreleaseLow: ( active: 12x ) # Low trace: None ``` -#### NTreleaseMedium: int: ms +#### NTreleaseMedium: accumulatorv In tutti i casi di NT @@ -274,7 +275,7 @@ NTreleaseMedium: ( active: 9x ) # Medium trace: None ``` -#### NTreleaseHigh: int: ms +#### NTreleaseHigh: accumulator ```Gen NTreleaseHigh: ( active: 3x ) # High @@ -288,7 +289,7 @@ NTreleaseHigh: ( active: 3x ) # High trace: None ``` -#### Ca2+TracesAccumulationLow: int: ms +#### Ca2+TracesAccumulationLow: accumulator Serve a: - fare il tuning dei VGCC @@ -312,7 +313,7 @@ Ca2+TracesAccumulationLow: ( active: 10x ) trace: None ``` -#### Ca2+TracesAccumulationMedium: int: ms +#### Ca2+TracesAccumulationMedium: accumulator ```Gen Ca2+TracesAccumulationMedium: ( active: 6x ) # medium @@ -325,7 +326,7 @@ Ca2+TracesAccumulationMedium: ( active: 6x ) # medium trace: None ``` -#### Ca2+TracesAccumulationHigh: int: ms +#### Ca2+TracesAccumulationHigh: accumulator ```Gen @@ -341,7 +342,7 @@ Ca2+TracesAccumulationHigh: ( active: 10x ) # high ### NOT AP_ctx: PRESYNAPSE -#### eCB clearance: int: sec +#### eCB clearance: accumulator eCB dipende da POST. Tende a modulare l'entrata di Ca2+ degli VGCC. @@ -358,7 +359,7 @@ eCBClearance: ( active: 24x ) # Slow trace: None ``` -#### RPShuttleLow: int: sec +#### RPShuttleLow: accumulator This happens in the seconds loop, once per second. @@ -379,7 +380,7 @@ RPShuttleLow: ( active: 48x ) # Low trace: None ``` -#### RPShuttleMedium: int: sec +#### RPShuttleMedium: accumulatorv The "Sub-Optimal" State. The machinery is working, but it's held back by partial limitations. This covers cases where the signal is steady but the "piston" isn't firing at full speed, or where a high vacancy in the RRP (emptiness) forces a low signal to work a bit harder. @@ -399,7 +400,7 @@ RPShuttleMedium: ( active: 24x ) # Medium trace: None ``` -#### RPShuttleHigh: int: sec +#### RPShuttleHigh: accumulator The "High Performance" State. Multiple systems are optimized, but one is still at a "mediumness" level. This represents an active synapse that hasn't reached its absolute peak because either the supply is only 50% or the RRP isn't empty enough to create that "maximal vacuum" pull. @@ -418,7 +419,7 @@ RPShuttleHigh: ( active: 12x ) # Fast trace: None ``` -#### RefillRPGlutamine: int: min +#### RefillRPGlutamine: accumulator This happens in the minutes loop, once per minute, via the glutamine shuttle from the astrocyte. It is a two-step process across two cells. @@ -450,7 +451,7 @@ Each tier buys time for the one below it to respond. When all three are depleted ### TunPossible_ctx: PRESYNAPSE -#### Ca2+TracesClearance: int: sec +#### Ca2+TracesClearance: accumulator Qui facciamo un flush di CaTraceX. Deve essere fatto a valle del tuning. @@ -493,7 +494,7 @@ VGCC-PRE Da rivedere le condizioni per aggiungere mGluR che ha come proxy NT concentration!!!!! -#### Ca2+enterLow: int: ms +#### Ca2+enterLow: accumulator Here we comprehend the breaking activity on VGCC by: CDI, eCB and mGluR: @@ -524,7 +525,7 @@ Ca2+enterLow: ( active: 12x ) # Low trace: None ``` -#### Ca2+enterMedium: int: ms +#### Ca2+enterMedium: accumulator ```Gen Ca2+enterMedium: ( active: 6x ) # Medium @@ -539,7 +540,7 @@ Ca2+enterMedium: ( active: 6x ) # Medium trace: None ``` -#### Ca2+enterHigh: int: ms +#### Ca2+enterHigh: accumulator ```Gen Ca2+enterHigh: ( active: 3x ) # High @@ -555,7 +556,7 @@ Ca2+enterHigh: ( active: 3x ) # High ### NOT AP_ctx: VGCC-PRE -#### Ca2+ClearanceLow: int: ms +#### Ca2+ClearanceLow: accumulator Qui eliminiamo Ca2+. Il tempo che ci mette ad eliminare il Ca2+ dovrebbe essere minoe dell'inervallo fra un AP_ctx e un'altra. Siccome non comprendiamo per ora ATP, non c'e' accumulo di Ca2+ per mancanza di ATP (stanchezza). @@ -580,7 +581,7 @@ Ca2+ClearanceLow: ( active: 24x ) # Low trace: None ``` -#### Ca2+ClearanceHigh: int: ms +#### Ca2+ClearanceHigh: accumulator ```Gen Ca2+ClearanceHigh: ( active: 4x ) # High @@ -616,7 +617,7 @@ VGCC-PRE-TUN ### TunPossible_ctx: VGCC-PRE-TUN -#### CheckVgccPreTun: contexting: sec +#### CheckVgccPreTun: contexting Qui controlliamo che ci siano le condizioni per aumentare o diminuire la quantita' di VGCC @@ -633,7 +634,7 @@ CheckVgccPreTun: ( active: 60x ) out_context: TryTunDownPreVcgg_ctx ``` -#### PossibleUpPreVgccTun: int: sec +#### PossibleUpPreVgccTun: accumulator ```Gen PossibleUpPreVgccTun: ( active: 10x ) @@ -646,7 +647,7 @@ PossibleUpPreVgccTun: ( active: 10x ) trace: ``` -#### PossibleDownPreVgccTun: int: sec +#### PossibleDownPreVgccTun: accumulator ```Gen PossibleDownPreVgccTun: ( active: 10x )