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ocrampal
2026-04-21 10:12:40 +02:00
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neuron/axon.md
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@@ -90,18 +90,17 @@ container: PRESYNAPSE
- CaTraces ( full: 50x, active: 0x, empty: 0x ) - CaTraces ( full: 50x, active: 0x, empty: 0x )
tub_intricated: tub_intricated:
- NT # SYN - NT ( contained_by: SYN )
- ATP? # - ATP ( contained_by: ? )
- eCB # from POST - eCB ( contained_by: POST )
context_intricated: context_intricated:
- AP ( contained_by: BEH-SOMA ) - AP ( contained_by: SOMA )
``` ```
### ms: behaviors ### ms: behaviors
#### AP-RRPConcentration: Context #### AP-RRPConcentration: check_tpc
Il rilascio di NT lo facciamo nel contesto di AP. Biologicamente dovrebbe avvenire solo in base alle concentrazioni, quindi anche al difuori degli AP. Il rilascio di NT lo facciamo nel contesto di AP. Biologicamente dovrebbe avvenire solo in base alle concentrazioni, quindi anche al difuori degli AP.
@@ -110,7 +109,7 @@ RF deve essere MOLTO piu' basso della durata di un AP. In maniera da essere atti
Questo poi per permettere la diversa contestualizzazione degli episodi di NTrelease, a piu' o meno alta velocita'. Questo poi per permettere la diversa contestualizzazione degli episodi di NTrelease, a piu' o meno alta velocita'.
```Gen ```Gen
context: AP-RRPConcentration check_tpc: AP-RRPConcentration
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: AP in_context: AP
@@ -123,12 +122,12 @@ context: AP-RRPConcentration
out_context: RRPFull out_context: RRPFull
``` ```
#### AP-Ca2+Concentration: Context #### AP-Ca2+Concentration: check_tpc
Qui controlliamo la concentrazione nel contesto di un AP. Qui controlliamo la concentrazione nel contesto di un AP.
```Gen ```Gen
context: AP-Ca2+Concentration check_tpc: AP-Ca2+Concentration
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: AP in_context: AP
@@ -149,12 +148,12 @@ Ci sono 4 casi che dipendono da RRP, Ca2+ e NT. L'idea e' che la quantita' di RR
![nt-release.png](.attachments/nt-release.png) ![nt-release.png](.attachments/nt-release.png)
##### NTreleaseMaximum: Episode ##### NTreleaseMaximum: interacting
NT empty NT empty
```Gen ```Gen
episode: NTreleaseMaximum interacting: NTreleaseMaximum
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: (Ca2+Full AND RRPFull) in_context: (Ca2+Full AND RRPFull)
@@ -165,12 +164,12 @@ episode: NTreleaseMaximum
trace: None trace: None
``` ```
##### NTreleaseHigh: Episode ##### NTreleaseHigh: interacting
Solo in questo caso NT modera! NT NOT empty Solo in questo caso NT modera! NT NOT empty
```Gen ```Gen
episode: NTreleaseHigh interacting: NTreleaseHigh
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: (Ca2+Full AND RRPFull) in_context: (Ca2+Full AND RRPFull)
@@ -181,12 +180,12 @@ episode: NTreleaseHigh
trace: None trace: None
``` ```
##### NTreleaseMediumness: Episode ##### NTreleaseMediumness: interacting
In tutti i casi di NT In tutti i casi di NT
```Gen ```Gen
episode: NTreleaseMediumness interacting: NTreleaseMediumness
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: (Ca2+Full AND RRPMediumness) OR (Ca2+Mediumness AND RRPFull) in_context: (Ca2+Full AND RRPMediumness) OR (Ca2+Mediumness AND RRPFull)
@@ -197,12 +196,12 @@ episode: NTreleaseMediumness
trace: None trace: None
``` ```
##### NTreleaseLow: Episode ##### NTreleaseLow: interacting
In tutti i casi di NT In tutti i casi di NT
```Gen ```Gen
episode: NTreleaseLow interacting: NTreleaseLow
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: (Ca2+Mediumness AND RRPMediumness) in_context: (Ca2+Mediumness AND RRPMediumness)
@@ -225,10 +224,10 @@ Quindi non comprendiamo anche il ristabilimento del Voltage, con altri Ioni entr
Abbiamo il caso di clearance nel contesto di un AP e non nel contesto di AP, per eliminare il Ca2+ fra le spike. Abbiamo il caso di clearance nel contesto di un AP e non nel contesto di AP, per eliminare il Ca2+ fra le spike.
##### AP-CaClearanceHigh: Episode ##### AP-CaClearanceHigh: interacting
```Gen ```Gen
episode: AP-CaClearanceHigh interacting: AP-CaClearanceHigh
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: Ca2+Full in_context: Ca2+Full
@@ -239,10 +238,10 @@ episode: AP-CaClearanceHigh
trace: None trace: None
``` ```
##### AP-CaClearanceMediumness: Episode ##### AP-CaClearanceMediumness: interacting
```Gen ```Gen
episode: AP-CaClearanceMediumness interacting: AP-CaClearanceMediumness
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: Ca2+Mediumness in_context: Ca2+Mediumness
@@ -253,10 +252,10 @@ episode: AP-CaClearanceMediumness
trace: None trace: None
``` ```
##### NotAP-CaClearance: Episode ##### NotAP-CaClearance: interacting
```Gen ```Gen
episode: NotAP-CaClearance interacting: NotAP-CaClearance
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: NOT AP in_context: NOT AP
@@ -275,10 +274,10 @@ So after one second of silence CaTrace has fallen to ~37% of its peak value, aft
The result is that Tr_Ca encodes not the instantaneous calcium level but the recent history of calcium activity — a smoothed, time-averaged measure of how active the synapse has been over the past one to two seconds. The result is that Tr_Ca encodes not the instantaneous calcium level but the recent history of calcium activity — a smoothed, time-averaged measure of how active the synapse has been over the past one to two seconds.
##### CaTracesAccumulationFast: Episode ##### CaTracesAccumulationFast: interacting
```Gen ```Gen
episode: CaTracesAccumulationFast interacting: CaTracesAccumulationFast
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: Ca2+Full in_context: Ca2+Full
@@ -289,10 +288,10 @@ episode: CaTracesAccumulationFast
trace: None trace: None
``` ```
##### CaTracesAccumulationSlow: Episode ##### CaTracesAccumulationSlow: interacting
```Gen ```Gen
episode: CaTracesAccumulationSlow interacting: CaTracesAccumulationSlow
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: Ca2+Full in_context: Ca2+Full
@@ -305,12 +304,12 @@ episode: CaTracesAccumulationSlow
### sec: behaviors ### sec: behaviors
#### CheckConditionsPreSec: Context #### CheckConditionsPreSec: check_tpc
Contestualizziamo in maniera Fixed ogni mezzo secondo? Contestualizziamo in maniera Fixed ogni mezzo secondo?
```Gen ```Gen
context: CheckConditionsPreSec check_tpc: CheckConditionsPreSec
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: Fixed in_context: Fixed
@@ -326,14 +325,14 @@ context: CheckConditionsPreSec
out_context: eCBNotEmpty out_context: eCBNotEmpty
``` ```
#### eCB clearance: Episode #### eCB clearance: interacting
eCB dipende da POST. Tende a modulare l'entrata di Ca2+ degli VGCC. eCB dipende da POST. Tende a modulare l'entrata di Ca2+ degli VGCC.
Qui non facciamo un flush di eCB, riduciamo ogni mezzo secondo (context) di un RF di questo episodio. Qui non facciamo un flush di eCB, riduciamo ogni mezzo secondo (context) di un RF di questo episodio.
```Gen ```Gen
episode: eCBClearance interacting: eCBClearance
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: eCBNotEmpty in_context: eCBNotEmpty
@@ -344,12 +343,12 @@ episode: eCBClearance
trace: None trace: None
``` ```
#### CaTraces clearance: Episode #### CaTraces clearance: interacting
Qui non facciamo un flush di Catrace, riduciamo ogni mezzo secondo (context) di un RF di questo episodio. Qui non facciamo un flush di Catrace, riduciamo ogni mezzo secondo (context) di un RF di questo episodio.
```Gen ```Gen
episode: CaTracesClearance interacting: CaTracesClearance
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: CaTracesNotEmpty in_context: CaTracesNotEmpty
@@ -364,14 +363,14 @@ episode: CaTracesClearance
This happens in the seconds loop, once per second. This happens in the seconds loop, once per second.
##### RPShuttleSlow: Episode ##### RPShuttleSlow: interacting
The "Hard Bottleneck" State. Recruitment is throttled by a lack of signal, a lack of supply, or a lack of space. If even one of these "Near-Stop" conditions is met, the rate cannot exceed "Slow," regardless of the other two conditions. The "Hard Bottleneck" State. Recruitment is throttled by a lack of signal, a lack of supply, or a lack of space. If even one of these "Near-Stop" conditions is met, the rate cannot exceed "Slow," regardless of the other two conditions.
Rate: 0.00 – 0.25 Rate: 0.00 – 0.25
```Gen ```Gen
episode: RPShuttleSlow interacting: RPShuttleSlow
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: RPShuttle in_context: RPShuttle
@@ -382,14 +381,14 @@ episode: RPShuttleSlow
trace: None trace: None
``` ```
##### RPShuttleModerate: Episode ##### RPShuttleModerate: interacting
The "Sub-Optimal" State. The machinery is working, but it's held back by partial limitations. This covers cases where the signal is steady but the "piston" isn't firing at full speed, or where a high vacancy in the RRP (emptiness) forces a low signal to work a bit harder. The "Sub-Optimal" State. The machinery is working, but it's held back by partial limitations. This covers cases where the signal is steady but the "piston" isn't firing at full speed, or where a high vacancy in the RRP (emptiness) forces a low signal to work a bit harder.
Rate: 0.50 – 0.97 Rate: 0.50 – 0.97
```Gen ```Gen
episode: RPShuttleModerate interacting: RPShuttleModerate
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: RPShuttle in_context: RPShuttle
@@ -403,14 +402,14 @@ episode: RPShuttleModerate
trace: None trace: None
``` ```
##### RPShuttleFast: Episode ##### RPShuttleFast: interacting
The "High Performance" State. Multiple systems are optimized, but one is still at a "mediumness" level. This represents an active synapse that hasn't reached its absolute peak because either the supply is only 50% or the RRP isn't empty enough to create that "maximal vacuum" pull. The "High Performance" State. Multiple systems are optimized, but one is still at a "mediumness" level. This represents an active synapse that hasn't reached its absolute peak because either the supply is only 50% or the RRP isn't empty enough to create that "maximal vacuum" pull.
Rate: 1.25 – 1.94 Rate: 1.25 – 1.94
```Gen ```Gen
episode: RPShuttleFast interacting: RPShuttleFast
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: RPShuttle in_context: RPShuttle
@@ -423,14 +422,14 @@ episode: RPShuttleFast
trace: None trace: None
``` ```
##### RPShuttleMaximal: Episode ##### RPShuttleMaximal: interacting
The "Total Recovery" State. All systems are at their theoretical peak for speed. The "Total Recovery" State. All systems are at their theoretical peak for speed.
Rate: 2.50 – 5.00 Rate: 2.50 – 5.00
```Gen ```Gen
episode: RPShuttleMaximal interacting: RPShuttleMaximal
contained_by: PRESYNAPSE contained_by: PRESYNAPSE
in_context: RPShuttle in_context: RPShuttle
@@ -490,7 +489,7 @@ tuner: VGCC-PRE-TUN
# la modulazione e' una pompa fra posMod e actMod e controlliamo # la modulazione e' una pompa fra posMod e actMod e controlliamo
# solo empty # solo empty
context_intricated: check_tpc_intricated:
- TunPossible ( contained_by: DAY-N ) - TunPossible ( contained_by: DAY-N )
tub_local: tub_local:
@@ -498,7 +497,7 @@ tuner: VGCC-PRE-TUN
tub_intricated: tub_intricated:
``` ```
##### Context ##### check_tpc
```Gen ```Gen
context: Check context: Check
@@ -511,10 +510,10 @@ context: Check
out_context: TunPreVcgg out_context: TunPreVcgg
``` ```
##### Episode ##### interacting
```Gen ```Gen
episode: Tun interacting: Tun
contained_by: VGCC-PRE-TUN contained_by: VGCC-PRE-TUN
in_context: TunPreVcgg in_context: TunPreVcgg
@@ -561,10 +560,10 @@ Qui sostituiamo:
Devo controllare che le condizioni sotto siano esaustive. Devo controllare che le condizioni sotto siano esaustive.
##### Ca2+enterOpen: Episode ##### Ca2+enterOpen: interacting
```Gen ```Gen
episode: Ca2+enterOpen interacting: Ca2+enterOpen
contained_by: VGCC-PRE contained_by: VGCC-PRE
in_context: AP in_context: AP
@@ -575,10 +574,10 @@ episode: Ca2+enterOpen
trace: None trace: None
``` ```
##### Ca2+enterReduced-partial: Episode ##### Ca2+enterReduced-partial: interacting
```Gen ```Gen
episode: Ca2+enterReduced-partial interacting: Ca2+enterReduced-partial
contained_by: VGCC-PRE contained_by: VGCC-PRE
in_context: AP in_context: AP
@@ -589,10 +588,10 @@ episode: Ca2+enterReduced-partial
trace: None trace: None
``` ```
##### Ca2+enterSuppressed: Episode ##### Ca2+enterSuppressed: interacting
```Gen ```Gen
episode: Ca2+enterSupressed interacting: Ca2+enterSupressed
contained_by: VGCC-PRE contained_by: VGCC-PRE
in_context: AP in_context: AP