diff --git a/neuron/axon.md b/neuron/axon.md index c1a3664..2ad8c9c 100644 --- a/neuron/axon.md +++ b/neuron/axon.md @@ -90,18 +90,17 @@ container: PRESYNAPSE - CaTraces ( full: 50x, active: 0x, empty: 0x ) tub_intricated: - - NT # SYN - - ATP? # - - eCB # from POST + - NT ( contained_by: SYN ) + - ATP ( contained_by: ? ) + - eCB ( contained_by: POST ) context_intricated: - - AP ( contained_by: BEH-SOMA ) - + - AP ( contained_by: SOMA ) ``` ### ms: behaviors -#### AP-RRPConcentration: Context +#### AP-RRPConcentration: check_tpc Il rilascio di NT lo facciamo nel contesto di AP. Biologicamente dovrebbe avvenire solo in base alle concentrazioni, quindi anche al difuori degli AP. @@ -110,7 +109,7 @@ RF deve essere MOLTO piu' basso della durata di un AP. In maniera da essere atti Questo poi per permettere la diversa contestualizzazione degli episodi di NTrelease, a piu' o meno alta velocita'. ```Gen -context: AP-RRPConcentration +check_tpc: AP-RRPConcentration contained_by: PRESYNAPSE in_context: AP @@ -123,12 +122,12 @@ context: AP-RRPConcentration out_context: RRPFull ``` -#### AP-Ca2+Concentration: Context +#### AP-Ca2+Concentration: check_tpc Qui controlliamo la concentrazione nel contesto di un AP. ```Gen -context: AP-Ca2+Concentration +check_tpc: AP-Ca2+Concentration contained_by: PRESYNAPSE in_context: AP @@ -149,12 +148,12 @@ Ci sono 4 casi che dipendono da RRP, Ca2+ e NT. L'idea e' che la quantita' di RR ![nt-release.png](.attachments/nt-release.png) -##### NTreleaseMaximum: Episode +##### NTreleaseMaximum: interacting NT empty ```Gen -episode: NTreleaseMaximum +interacting: NTreleaseMaximum contained_by: PRESYNAPSE in_context: (Ca2+Full AND RRPFull) @@ -165,12 +164,12 @@ episode: NTreleaseMaximum trace: None ``` -##### NTreleaseHigh: Episode +##### NTreleaseHigh: interacting Solo in questo caso NT modera! NT NOT empty ```Gen -episode: NTreleaseHigh +interacting: NTreleaseHigh contained_by: PRESYNAPSE in_context: (Ca2+Full AND RRPFull) @@ -181,12 +180,12 @@ episode: NTreleaseHigh trace: None ``` -##### NTreleaseMediumness: Episode +##### NTreleaseMediumness: interacting In tutti i casi di NT ```Gen -episode: NTreleaseMediumness +interacting: NTreleaseMediumness contained_by: PRESYNAPSE in_context: (Ca2+Full AND RRPMediumness) OR (Ca2+Mediumness AND RRPFull) @@ -197,12 +196,12 @@ episode: NTreleaseMediumness trace: None ``` -##### NTreleaseLow: Episode +##### NTreleaseLow: interacting In tutti i casi di NT ```Gen -episode: NTreleaseLow +interacting: NTreleaseLow contained_by: PRESYNAPSE in_context: (Ca2+Mediumness AND RRPMediumness) @@ -225,10 +224,10 @@ Quindi non comprendiamo anche il ristabilimento del Voltage, con altri Ioni entr Abbiamo il caso di clearance nel contesto di un AP e non nel contesto di AP, per eliminare il Ca2+ fra le spike. -##### AP-CaClearanceHigh: Episode +##### AP-CaClearanceHigh: interacting ```Gen -episode: AP-CaClearanceHigh +interacting: AP-CaClearanceHigh contained_by: PRESYNAPSE in_context: Ca2+Full @@ -239,10 +238,10 @@ episode: AP-CaClearanceHigh trace: None ``` -##### AP-CaClearanceMediumness: Episode +##### AP-CaClearanceMediumness: interacting ```Gen -episode: AP-CaClearanceMediumness +interacting: AP-CaClearanceMediumness contained_by: PRESYNAPSE in_context: Ca2+Mediumness @@ -253,10 +252,10 @@ episode: AP-CaClearanceMediumness trace: None ``` -##### NotAP-CaClearance: Episode +##### NotAP-CaClearance: interacting ```Gen -episode: NotAP-CaClearance +interacting: NotAP-CaClearance contained_by: PRESYNAPSE in_context: NOT AP @@ -275,10 +274,10 @@ So after one second of silence CaTrace has fallen to ~37% of its peak value, aft The result is that Tr_Ca encodes not the instantaneous calcium level but the recent history of calcium activity — a smoothed, time-averaged measure of how active the synapse has been over the past one to two seconds. -##### CaTracesAccumulationFast: Episode +##### CaTracesAccumulationFast: interacting ```Gen -episode: CaTracesAccumulationFast +interacting: CaTracesAccumulationFast contained_by: PRESYNAPSE in_context: Ca2+Full @@ -289,10 +288,10 @@ episode: CaTracesAccumulationFast trace: None ``` -##### CaTracesAccumulationSlow: Episode +##### CaTracesAccumulationSlow: interacting ```Gen -episode: CaTracesAccumulationSlow +interacting: CaTracesAccumulationSlow contained_by: PRESYNAPSE in_context: Ca2+Full @@ -305,12 +304,12 @@ episode: CaTracesAccumulationSlow ### sec: behaviors -#### CheckConditionsPreSec: Context +#### CheckConditionsPreSec: check_tpc Contestualizziamo in maniera Fixed ogni mezzo secondo? ```Gen -context: CheckConditionsPreSec +check_tpc: CheckConditionsPreSec contained_by: PRESYNAPSE in_context: Fixed @@ -326,14 +325,14 @@ context: CheckConditionsPreSec out_context: eCBNotEmpty ``` -#### eCB clearance: Episode +#### eCB clearance: interacting eCB dipende da POST. Tende a modulare l'entrata di Ca2+ degli VGCC. Qui non facciamo un flush di eCB, riduciamo ogni mezzo secondo (context) di un RF di questo episodio. ```Gen -episode: eCBClearance +interacting: eCBClearance contained_by: PRESYNAPSE in_context: eCBNotEmpty @@ -344,12 +343,12 @@ episode: eCBClearance trace: None ``` -#### CaTraces clearance: Episode +#### CaTraces clearance: interacting Qui non facciamo un flush di Catrace, riduciamo ogni mezzo secondo (context) di un RF di questo episodio. ```Gen -episode: CaTracesClearance +interacting: CaTracesClearance contained_by: PRESYNAPSE in_context: CaTracesNotEmpty @@ -364,14 +363,14 @@ episode: CaTracesClearance This happens in the seconds loop, once per second. -##### RPShuttleSlow: Episode +##### RPShuttleSlow: interacting The "Hard Bottleneck" State. Recruitment is throttled by a lack of signal, a lack of supply, or a lack of space. If even one of these "Near-Stop" conditions is met, the rate cannot exceed "Slow," regardless of the other two conditions. Rate: 0.00 – 0.25 ```Gen -episode: RPShuttleSlow +interacting: RPShuttleSlow contained_by: PRESYNAPSE in_context: RPShuttle @@ -382,14 +381,14 @@ episode: RPShuttleSlow trace: None ``` -##### RPShuttleModerate: Episode +##### RPShuttleModerate: interacting The "Sub-Optimal" State. The machinery is working, but it's held back by partial limitations. This covers cases where the signal is steady but the "piston" isn't firing at full speed, or where a high vacancy in the RRP (emptiness) forces a low signal to work a bit harder. Rate: 0.50 – 0.97 ```Gen -episode: RPShuttleModerate +interacting: RPShuttleModerate contained_by: PRESYNAPSE in_context: RPShuttle @@ -403,14 +402,14 @@ episode: RPShuttleModerate trace: None ``` -##### RPShuttleFast: Episode +##### RPShuttleFast: interacting The "High Performance" State. Multiple systems are optimized, but one is still at a "mediumness" level. This represents an active synapse that hasn't reached its absolute peak because either the supply is only 50% or the RRP isn't empty enough to create that "maximal vacuum" pull. Rate: 1.25 – 1.94 ```Gen -episode: RPShuttleFast +interacting: RPShuttleFast contained_by: PRESYNAPSE in_context: RPShuttle @@ -423,14 +422,14 @@ episode: RPShuttleFast trace: None ``` -##### RPShuttleMaximal: Episode +##### RPShuttleMaximal: interacting The "Total Recovery" State. All systems are at their theoretical peak for speed. Rate: 2.50 – 5.00 ```Gen -episode: RPShuttleMaximal +interacting: RPShuttleMaximal contained_by: PRESYNAPSE in_context: RPShuttle @@ -490,7 +489,7 @@ tuner: VGCC-PRE-TUN # la modulazione e' una pompa fra posMod e actMod e controlliamo # solo empty - context_intricated: + check_tpc_intricated: - TunPossible ( contained_by: DAY-N ) tub_local: @@ -498,7 +497,7 @@ tuner: VGCC-PRE-TUN tub_intricated: ``` -##### Context +##### check_tpc ```Gen context: Check @@ -511,10 +510,10 @@ context: Check out_context: TunPreVcgg ``` -##### Episode +##### interacting ```Gen -episode: Tun +interacting: Tun contained_by: VGCC-PRE-TUN in_context: TunPreVcgg @@ -561,10 +560,10 @@ Qui sostituiamo: Devo controllare che le condizioni sotto siano esaustive. -##### Ca2+enterOpen: Episode +##### Ca2+enterOpen: interacting ```Gen -episode: Ca2+enterOpen +interacting: Ca2+enterOpen contained_by: VGCC-PRE in_context: AP @@ -575,10 +574,10 @@ episode: Ca2+enterOpen trace: None ``` -##### Ca2+enterReduced-partial: Episode +##### Ca2+enterReduced-partial: interacting ```Gen -episode: Ca2+enterReduced-partial +interacting: Ca2+enterReduced-partial contained_by: VGCC-PRE in_context: AP @@ -589,10 +588,10 @@ episode: Ca2+enterReduced-partial trace: None ``` -##### Ca2+enterSuppressed: Episode +##### Ca2+enterSuppressed: interacting ```Gen -episode: Ca2+enterSupressed +interacting: Ca2+enterSupressed contained_by: VGCC-PRE in_context: AP