Update 2026-06-04-modulation-of-future-behavior.md
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@@ -31,7 +31,7 @@ mGluR5_activation // astrocytic Gq — IP3 → Ca²⁺ → D-serine cascade
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```
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## layer 1 — Ca²⁺: did something happen?
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```Gen
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function Ca_event_recorder(spike_history, input_freq):
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// Presynapse: residual Ca²⁺ = trace of recent firing
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@@ -58,9 +58,11 @@ if astro_Ca_local > local_threshold:
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D_serine_release += gliotransmitter_pulse() // widens NMDA window
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if astro_Ca_global:
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trigger(shockwave_lockdown) // circuit-breaker
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```
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## layer 2 — mGluRs: was it excessive?
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```Gen
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function mGluR_overflow_sensor():
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// Only fires when cleft is genuinely saturated (low-affinity receptors)
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@@ -102,9 +104,11 @@ DARPP32_phospho = True // inhibits PP1 → LTD pathway blocked
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translocate(PKA → nucleus)
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phosphorylate(CREB)
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CREB_active = True // new receptors, cytoskeleton, scaffolding
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```
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## hierarchical filter — commit decision
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```Gen
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function commit_to_structural_change():
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// All three layers must align
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@@ -129,6 +133,7 @@ return "depressed"
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else:
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return "baseline — no change"
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```
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## End
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