From bb29dd3f00f7305f55abee56cfdb7bb8eb57165e Mon Sep 17 00:00:00 2001 From: ocrampal Date: Thu, 4 Jun 2026 17:53:15 +0200 Subject: [PATCH] Update 2026-06-04-modulation-of-future-behavior.md --- .../appunti/2026-06-04-modulation-of-future-behavior.md | 7 ++++++- 1 file changed, 6 insertions(+), 1 deletion(-) diff --git a/elements/astrocyte/appunti/2026-06-04-modulation-of-future-behavior.md b/elements/astrocyte/appunti/2026-06-04-modulation-of-future-behavior.md index faed59b..8098081 100644 --- a/elements/astrocyte/appunti/2026-06-04-modulation-of-future-behavior.md +++ b/elements/astrocyte/appunti/2026-06-04-modulation-of-future-behavior.md @@ -31,7 +31,7 @@ mGluR5_activation // astrocytic Gq — IP3 → Ca²⁺ → D-serine cascade ``` ## layer 1 — Ca²⁺: did something happen? - +```Gen function Ca_event_recorder(spike_history, input_freq): // Presynapse: residual Ca²⁺ = trace of recent firing @@ -58,9 +58,11 @@ if astro_Ca_local > local_threshold: D_serine_release += gliotransmitter_pulse() // widens NMDA window if astro_Ca_global: trigger(shockwave_lockdown) // circuit-breaker +``` ## layer 2 — mGluRs: was it excessive? +```Gen function mGluR_overflow_sensor(): // Only fires when cleft is genuinely saturated (low-affinity receptors) @@ -102,9 +104,11 @@ DARPP32_phospho = True // inhibits PP1 → LTD pathway blocked translocate(PKA → nucleus) phosphorylate(CREB) CREB_active = True // new receptors, cytoskeleton, scaffolding +``` ## hierarchical filter — commit decision +```Gen function commit_to_structural_change(): // All three layers must align @@ -129,6 +133,7 @@ return "depressed" else: return "baseline — no change" +``` ## End