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Update elements/neuron/presynapse.md

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Sergio Marchetti
2026-05-30 12:04:55 +02:00
parent c8ed45c0c9
commit a89de909d9
1 changed files with 41 additions and 38 deletions
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elements/neuron/presynapse.md
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@@ -29,6 +29,7 @@ PRESYNAPSE
# Context
*AP: INTRICATION [ ref: &SOMA.*AP]
*TunePossible: INTRICATION [ref: &...] # To be defined...
# Tub
_NT: INTRICATION [ ref: &ASTROSYNAPSE._NT]
@@ -38,13 +39,14 @@ PRESYNAPSE
instantiation:
# Context
*TunePossible: CONTEXT [ref: &...]
# Tub
_Ca2: TUB [ full: 60x, active: 30x, empty: 0x ]
_Rrp: TUB [ full: 30x, active: 15x, empty: 0x ]
_Rp: TUB [ full: 30x, active: 15x, empty: 0x ]
_CaTraces: TUB [ full: 50x, active: 0x, empty: 0x ]
_CaTracesHigh: TUB [ full: 50x, active: 0x, empty: 0x ]
_CaTracesMedium: TUB [ full: 50x, active: 0x, empty: 0x ]
_CaTracesLow: TUB [ full: 50x, active: 0x, empty: 0x ]
_Ca2FullDev: TUB [ full: 100x, active: _Ca2.full, empty: 40x ]
# serve al dev
@@ -92,7 +94,7 @@ MAIN_PRE
- **_Rrp**: Readily Releasable Pool: The Readily Releasable Pool consists of the vesicles that are "docked" and "primed" at the active zone of the synapse. This pool is very small (usually only about 0.5% to 5% of total vesicles) and can be exhausted quickly during high-frequency firing, leading to "short-term depression" of the signal. Here we consider them as NT ready to be released.
- **_Rp**: Reserve Pool: The bulk of the vesicles held further back in the terminal, often tethered by a protein called synapsin. These are only mobilized during intense, prolonged stimulation. This makes up the vast majority of the vesicles (up to 80% or 90%). Here we consider them NT in reserve that can be transfered to RRP and created using Glutamine from Astorcyte.
- **_NT**: Neuro Transmitter, released in the synapse by the vescicles. The release increses NT and decreases RRP
- **_CaTraces**: sono le tracce di permanenza della concentrazione di Ca2. Servono alla modulazione (TUN)
- **_CaTracesXXX**: sono le tracce di permanenza della concentrazione di Ca2. Servono alla modulazione (TUN)
- **_eCB**: retrograde signal updates from postsynapsis (postsynaptic input)
#### *AP
@@ -120,8 +122,8 @@ NTreleaseLow
in_context: *AP
hypothesis: ( _Ca2 mediumness ) AND ( _Rrp mediumness ) AND NOT( _ATP empty )
action: [_Rrp decrease, _Nt increase, _ATP decrease]
hypothesis: _Ca2 mediumness AND _Rrp mediumness AND NOT _ATP empty
action: [_Rrp decrease, _NT increase, _ATP decrease]
trace: None
```
@@ -132,10 +134,10 @@ NTreleaseMedium
in_context: *AP
hypothesis: (( _Ca2 fullness ) AND ( _Rrp mediumness ) OR
( _Ca2 mediumness ) AND ( _Rrp fullness )) AND
NOT( _ATP empty )
action: [_Rrp decrease, Nt increase, _ATP decrease]
hypothesis: ( _Ca2 fullness AND _Rrp mediumness ) OR
( _Ca2 mediumness AND _Rrp fullness ) AND
NOT _ATP empty
action: [_Rrp decrease, _NT increase, _ATP decrease]
trace: None
```
@@ -146,8 +148,8 @@ NTreleaseHigh
in_context: *AP
hypothesis: ( _Ca2 fullness ) AND ( _Rrp fullness ) AND
NOT( _ATP empty )
hypothesis: ( _Ca2 fullness AND _Rrp fullness ) AND
NOT _ATP empty
action: [_Rrp decrease, NT increase, _ATP decrease]
trace: None
```
@@ -169,8 +171,8 @@ Ca2TracesAccuLow
in_context: *AP
hypothesis: (_Ca2 emptiness)
action: [CaTraceLow increase]
hypothesis: _Ca2 emptiness
action: [ _CaTraceLow increase ]
trace: None
```
@@ -181,8 +183,8 @@ Ca2TracesAccMedium
in_context: *AP
hypothesis: (_Ca2 mediumness)
action: [CaTraceMed increase]
hypothesis: _Ca2 mediumness
action: [ _CaTraceMed increase ]
trace: None
```
@@ -193,8 +195,8 @@ Ca2TracesAccumulationHigh
in_context: *AP
hypothesis: (_Ca2 fullness)
action: [CaTraceHigh increase]
hypothesis: _Ca2 fullness
action: [ _CaTraceHigh increase ]
trace: None
```
@@ -211,8 +213,8 @@ eCBClearance: ( active: 24x ) # Slow
in_context: NOT *AP
hypothesis: NOT (eCB empty)
action: [eCB decrease]
hypothesis: NOT _eCB empty
action: [ _eCB decrease ]
trace: None
```
@@ -229,9 +231,9 @@ RPShuttleLow
in_context: NOT *AP
hypothesis: (CaTraceLow fullness) OR
(RP emptiness) OR
(_Rrp fullness)
hypothesis: _CaTraceLow fullness OR
_RP emptiness OR
_Rrp fullness
action: [RP decrease, _Rrp increase]
trace: None
```
@@ -247,10 +249,10 @@ RPShuttleMedium
in_context: *AP
hypothesis: (CaTraceMedium fullness) AND (RP mediumness) AND (_Rrp mediumness) OR
(CaTraceHigh fullness) AND (RP mediumness) AND (_Rrp mediumness) OR # signal boost
(CaTraceMedium fullness) AND (RP fullness) AND (_Rrp mediumness) OR # supply boost
(CaTraceMedium fullness) AND (RP mediumness) AND (_Rrp emptiness) # vacancy boost
hypothesis: ( _CaTraceMedium fullness AND _RP mediumness AND _Rrp mediumness ) OR
( _CaTraceHigh fullness AND _RP mediumness AND _Rrp mediumness ) OR # signal boost
( _CaTraceMedium fullness AND _RP fullness AND _Rrp mediumness ) OR # supply boost
( _CaTraceMedium fullness AND _RP mediumness AND _Rrp emptiness ) # vacancy boost
action: [RP decrease, _Rrp increase]
trace: None
```
@@ -266,10 +268,10 @@ RPShuttleHigh
in_context: *AP
hypothesis: (CaTraceHigh fullness) AND (RP fullness) AND (_Rrp mediumness) OR # signal + supply
(CaTraceHigh fullness) AND (RP mediumness) AND (_Rrp emptiness) OR # signal + vacancy
(CaTraceMedium fullness) AND (RP fullness) AND (_Rrp emptiness) # supply + vacancy
action: [RP decrease, _Rrp increase]
hypothesis: ( _CaTraceHigh fullness AND _RP fullness AND _Rrp mediumness ) OR # signal + supply
( _CaTraceHigh fullness AND _RP mediumness AND _Rrp emptiness ) OR # signal + vacancy
( _CaTraceMedium fullness AND _RP fullness AND _Rrp emptiness ) # supply + vacancy
action: [ _RP decrease, _Rrp increase]
trace: None
```
@@ -312,16 +314,16 @@ Ca2TracesClearance
in_context: NOT *TunePossible
hypothesis: NOT (CaTraceHigh empty)
action: [CaTRaceHigh decrease]
hypothesis: NOT _CaTraceHigh empty
action: [ _CaTRaceHigh decrease ]
trace: None
hypothesis: NOT (CaTraceMedium empty)
action: [CaTRaceMedium decrease]
hypothesis: NOT _CaTraceMedium empty
action: [ _CaTRaceMedium decrease ]
trace: None
hypothesis: NOT (CaTraceLow empty)
action: [CaTRaceLow decrease]
hypothesis: NOT _CaTraceLow empty
action: [ _CaTRaceLow decrease ]
trace: None
```
@@ -330,11 +332,12 @@ Ca2TracesClearance
```Gen
TUNE_VGCC_PRE
# qui stiamo aggiungendo o eliminando {VGCC_PRE}. Fra un massimo full e minimo empty (empty puo' non essere 0)
type: behaviour
# qui stiamo aggiungendo o eliminando VGCC_PRE. Fra un massimo full e minimo empty (empty puo' non essere 0)
# contained_by: PRESYNAPSE non e' contenuto, si attacca.
activity_scope: !DAY
type: behaviour
context_intricated:
- *TunePossible ( contained_by: DAY-N )