From a89de909d9fc39df5116fd7c35d2982ced03b524 Mon Sep 17 00:00:00 2001 From: Sergio Marchetti Date: Sat, 30 May 2026 12:04:55 +0200 Subject: [PATCH] Update elements/neuron/presynapse.md --- elements/neuron/presynapse.md | 79 ++++++++++++++++++----------------- 1 file changed, 41 insertions(+), 38 deletions(-) diff --git a/elements/neuron/presynapse.md b/elements/neuron/presynapse.md index 865b15e..1c4d528 100644 --- a/elements/neuron/presynapse.md +++ b/elements/neuron/presynapse.md @@ -29,6 +29,7 @@ PRESYNAPSE # Context *AP: INTRICATION [ ref: &SOMA.*AP] + *TunePossible: INTRICATION [ref: &...] # To be defined... # Tub _NT: INTRICATION [ ref: &ASTROSYNAPSE._NT] @@ -38,13 +39,14 @@ PRESYNAPSE instantiation: # Context - *TunePossible: CONTEXT [ref: &...] # Tub _Ca2: TUB [ full: 60x, active: 30x, empty: 0x ] _Rrp: TUB [ full: 30x, active: 15x, empty: 0x ] _Rp: TUB [ full: 30x, active: 15x, empty: 0x ] - _CaTraces: TUB [ full: 50x, active: 0x, empty: 0x ] + _CaTracesHigh: TUB [ full: 50x, active: 0x, empty: 0x ] + _CaTracesMedium: TUB [ full: 50x, active: 0x, empty: 0x ] + _CaTracesLow: TUB [ full: 50x, active: 0x, empty: 0x ] _Ca2FullDev: TUB [ full: 100x, active: _Ca2.full, empty: 40x ] # serve al dev @@ -92,7 +94,7 @@ MAIN_PRE - **_Rrp**: Readily Releasable Pool: The Readily Releasable Pool consists of the vesicles that are "docked" and "primed" at the active zone of the synapse. This pool is very small (usually only about 0.5% to 5% of total vesicles) and can be exhausted quickly during high-frequency firing, leading to "short-term depression" of the signal. Here we consider them as NT ready to be released. - **_Rp**: Reserve Pool: The bulk of the vesicles held further back in the terminal, often tethered by a protein called synapsin. These are only mobilized during intense, prolonged stimulation. This makes up the vast majority of the vesicles (up to 80% or 90%). Here we consider them NT in reserve that can be transfered to RRP and created using Glutamine from Astorcyte. - **_NT**: Neuro Transmitter, released in the synapse by the vescicles. The release increses NT and decreases RRP -- **_CaTraces**: sono le tracce di permanenza della concentrazione di Ca2. Servono alla modulazione (TUN) +- **_CaTracesXXX**: sono le tracce di permanenza della concentrazione di Ca2. Servono alla modulazione (TUN) - **_eCB**: retrograde signal updates from postsynapsis (postsynaptic input) #### *AP @@ -120,8 +122,8 @@ NTreleaseLow in_context: *AP - hypothesis: ( _Ca2 mediumness ) AND ( _Rrp mediumness ) AND NOT( _ATP empty ) - action: [_Rrp decrease, _Nt increase, _ATP decrease] + hypothesis: _Ca2 mediumness AND _Rrp mediumness AND NOT _ATP empty + action: [_Rrp decrease, _NT increase, _ATP decrease] trace: None ``` @@ -132,10 +134,10 @@ NTreleaseMedium in_context: *AP - hypothesis: (( _Ca2 fullness ) AND ( _Rrp mediumness ) OR - ( _Ca2 mediumness ) AND ( _Rrp fullness )) AND - NOT( _ATP empty ) - action: [_Rrp decrease, Nt increase, _ATP decrease] + hypothesis: ( _Ca2 fullness AND _Rrp mediumness ) OR + ( _Ca2 mediumness AND _Rrp fullness ) AND + NOT _ATP empty + action: [_Rrp decrease, _NT increase, _ATP decrease] trace: None ``` @@ -146,8 +148,8 @@ NTreleaseHigh in_context: *AP - hypothesis: ( _Ca2 fullness ) AND ( _Rrp fullness ) AND - NOT( _ATP empty ) + hypothesis: ( _Ca2 fullness AND _Rrp fullness ) AND + NOT _ATP empty action: [_Rrp decrease, NT increase, _ATP decrease] trace: None ``` @@ -169,8 +171,8 @@ Ca2TracesAccuLow in_context: *AP - hypothesis: (_Ca2 emptiness) - action: [CaTraceLow increase] + hypothesis: _Ca2 emptiness + action: [ _CaTraceLow increase ] trace: None ``` @@ -181,8 +183,8 @@ Ca2TracesAccMedium in_context: *AP - hypothesis: (_Ca2 mediumness) - action: [CaTraceMed increase] + hypothesis: _Ca2 mediumness + action: [ _CaTraceMed increase ] trace: None ``` @@ -193,8 +195,8 @@ Ca2TracesAccumulationHigh in_context: *AP - hypothesis: (_Ca2 fullness) - action: [CaTraceHigh increase] + hypothesis: _Ca2 fullness + action: [ _CaTraceHigh increase ] trace: None ``` @@ -211,8 +213,8 @@ eCBClearance: ( active: 24x ) # Slow in_context: NOT *AP - hypothesis: NOT (eCB empty) - action: [eCB decrease] + hypothesis: NOT _eCB empty + action: [ _eCB decrease ] trace: None ``` @@ -229,9 +231,9 @@ RPShuttleLow in_context: NOT *AP - hypothesis: (CaTraceLow fullness) OR - (RP emptiness) OR - (_Rrp fullness) + hypothesis: _CaTraceLow fullness OR + _RP emptiness OR + _Rrp fullness action: [RP decrease, _Rrp increase] trace: None ``` @@ -247,10 +249,10 @@ RPShuttleMedium in_context: *AP - hypothesis: (CaTraceMedium fullness) AND (RP mediumness) AND (_Rrp mediumness) OR - (CaTraceHigh fullness) AND (RP mediumness) AND (_Rrp mediumness) OR # signal boost - (CaTraceMedium fullness) AND (RP fullness) AND (_Rrp mediumness) OR # supply boost - (CaTraceMedium fullness) AND (RP mediumness) AND (_Rrp emptiness) # vacancy boost + hypothesis: ( _CaTraceMedium fullness AND _RP mediumness AND _Rrp mediumness ) OR + ( _CaTraceHigh fullness AND _RP mediumness AND _Rrp mediumness ) OR # signal boost + ( _CaTraceMedium fullness AND _RP fullness AND _Rrp mediumness ) OR # supply boost + ( _CaTraceMedium fullness AND _RP mediumness AND _Rrp emptiness ) # vacancy boost action: [RP decrease, _Rrp increase] trace: None ``` @@ -266,10 +268,10 @@ RPShuttleHigh in_context: *AP - hypothesis: (CaTraceHigh fullness) AND (RP fullness) AND (_Rrp mediumness) OR # signal + supply - (CaTraceHigh fullness) AND (RP mediumness) AND (_Rrp emptiness) OR # signal + vacancy - (CaTraceMedium fullness) AND (RP fullness) AND (_Rrp emptiness) # supply + vacancy - action: [RP decrease, _Rrp increase] + hypothesis: ( _CaTraceHigh fullness AND _RP fullness AND _Rrp mediumness ) OR # signal + supply + ( _CaTraceHigh fullness AND _RP mediumness AND _Rrp emptiness ) OR # signal + vacancy + ( _CaTraceMedium fullness AND _RP fullness AND _Rrp emptiness ) # supply + vacancy + action: [ _RP decrease, _Rrp increase] trace: None ``` @@ -312,16 +314,16 @@ Ca2TracesClearance in_context: NOT *TunePossible - hypothesis: NOT (CaTraceHigh empty) - action: [CaTRaceHigh decrease] + hypothesis: NOT _CaTraceHigh empty + action: [ _CaTRaceHigh decrease ] trace: None - hypothesis: NOT (CaTraceMedium empty) - action: [CaTRaceMedium decrease] + hypothesis: NOT _CaTraceMedium empty + action: [ _CaTRaceMedium decrease ] trace: None - hypothesis: NOT (CaTraceLow empty) - action: [CaTRaceLow decrease] + hypothesis: NOT _CaTraceLow empty + action: [ _CaTRaceLow decrease ] trace: None ``` @@ -330,11 +332,12 @@ Ca2TracesClearance ```Gen TUNE_VGCC_PRE - # qui stiamo aggiungendo o eliminando {VGCC_PRE}. Fra un massimo full e minimo empty (empty puo' non essere 0) + type: behaviour + + # qui stiamo aggiungendo o eliminando VGCC_PRE. Fra un massimo full e minimo empty (empty puo' non essere 0) # contained_by: PRESYNAPSE non e' contenuto, si attacca. activity_scope: !DAY - type: behaviour context_intricated: - *TunePossible ( contained_by: DAY-N )