Sergio
This commit is contained in:
Sergio Marchetti
+115
-115
@@ -2,10 +2,10 @@
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Qui comprendiamo:
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- BEH-POST: Postsynapse
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- BEH-POST-AMPA: AMPA receptors (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors)
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- POSTSYNAPSE: Postsynapse
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- POST-AMPA: AMPA receptors (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors)
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## BEH-POST: Container
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## POSTSYNAPSE: Container
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**Simplified Behaviors**:
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@@ -44,14 +44,13 @@ POSTSYNAPSE
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-- Ca Influx
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CaNDMAEnterMax: interacting
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CaNDMAEnterMed: interacting
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-- Ca Clearence
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AP-CaClearanceHigh: interacting
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AP-CaClearanceMedium: interacting
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- NOT bAP_ctx:
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-- Ca Influx
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CaNDMAEnterMedNotBap: interacting
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CaNDMAEnterLow: interacting
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-- Ca Clearence
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CaClearance: interacting
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- Fixed??
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-- V Influx
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@@ -61,17 +60,17 @@ POSTSYNAPSE
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-- V Clearence
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VPostClearance: interacting
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POST-AMPA
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- Fixed??
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-- Na Influx
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NaAMPAEnterMax: interacting
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NaAMPAEnterMed: interacting
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POST-AMPA
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- Fixed??
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-- Na Influx
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NaAMPAEnterMax: interacting
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NaAMPAEnterMed: interacting
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POST-NA-CLEAR
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- Fixed??
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-- Na Clearence
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NaClearanceHigh: interacting
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NaClearanceLow: interacting
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POST-NA-CLEAR
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- Fixed??
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-- Na Clearence
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NaClearanceHigh: interacting
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NaClearanceLow: interacting
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```
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@@ -79,43 +78,35 @@ POST-NA-CLEAR
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**Tubs:**
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- **Na**: Ioni entranti tramite AMPA receptors
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- **NT**:
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- **Ca2+**: Ioni entranti tramite NMDA
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- **VPost**: il voltage che viene sentito in DB
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- **eCB**:
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- **Nox**:?
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---
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```Gen
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container: BEH-POST
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container: POSTSYNAPSE
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expansion:
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- POST-AMPA ( full: 10x, active: 5x, empty: 2x )
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# modulated_by: TUN-POST-IC # possible/actual
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- POST-NA-CLEAR ( full: 1x, active: 1x, empty: 0x )
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# modulated_by: ??
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tub_local:
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- Ca2+ ( full: 60x, active: 30x, empty: 0x )
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- Na ( full: 60x, active: 30x, empty: 0x )
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- Nox ( full: 100x, active: 20x, empty: 0x ) # Nitric Oxide (NO): A gas that diffuses freely.
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- eCB ( full: 100x, active: 20x, empty: 0x ) # Endocannabinoids (e.g., 2-AG)
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tub_intricated:
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- Nt ( contained_by: BEH-SYN )
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- VPost ( contained_by: BEH-BD )
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- NT ( contained_by: SYNAPSE )
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- VPost ( contained_by: BD )
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context_intricated:
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- bAp ( contained_by: BEH-SOMA )
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- bAp ( contained_by: SOMA )
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```
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### ms: behaviors POST
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@@ -127,7 +118,7 @@ container: BEH-POST
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Contestualizziamo in maniera Fixed?
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```Gen
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context: CheckNa
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context: CheckNa ## DA ELIMINARE ##
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contained_by: BEH-POST
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in_context: Fixed
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@@ -143,53 +134,68 @@ context: CheckNa
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out_context: NaLow
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```
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##### CaNDMAEnterMax: Episode
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##### CaNDMAEnterMax: Interacting
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```Gen
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episode: CaNDMAEnterMax
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contained_by: BEH-POST
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interacting: CaNDMAEnterMax
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contained_by: POSTSYNAPSE
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in_context: bAp AND (NaMax OR NaMedium)
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in_context: bAp
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rf: ( active: 2x )
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hypothesis: NOT (Ca2+ full)
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hypothesis: NOT (Ca2+ full) AND
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(Na fullness OR Na mediumness)
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action: [Ca2+ increase]
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trace:
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```
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##### CaNDMAEnterMed: Episode
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##### CaNDMAEnterMed: Interacting
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```Gen
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episode: CaNDMAEnterMed
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contained_by: BEH-POST
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interacting: CaNDMAEnterMed
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contained_by: POSTSYNAPSE
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in_context: (bAp AND NaLow) OR (NOT bAP AND NaMax)
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in_context: bAp
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rf: ( active: 4x )
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hypothesis: NOT (Ca2+ full)
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hypothesis: NOT (Ca2+ full) AND (Na emptiness)
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action: [Ca2+ increase]
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trace:
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```
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##### CaNDMAEnterLow: Episode
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##### CaNDMAEnterMedNotBap: Interacting
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```Gen
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episode: CaNDMAEnterLow
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contained_by: BEH-POST
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interacting: CaNDMAEnterMedNotBap
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contained_by: POSTSYNAPSE
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in_context: NOT bAP AND NaMedium
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in_context: NOT bAP
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rf: ( active: 4x )
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hypothesis: NOT (Ca2+ full) AND (Na fullness)
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action: [Ca2+ increase]
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trace:
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```
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##### CaNDMAEnterLow: Interacting
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```Gen
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interacting: CaNDMAEnterLow
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contained_by: POSTSYNAPSE
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in_context: NOT bAP
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rf: ( active: 12x )
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hypothesis: NOT (Ca2+ full)
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hypothesis: NOT (Ca2+ full) AND (Na mediumness)
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action: [Ca2+ increase]
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trace:
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```
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#### CaClearance: Episode
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#### CaClearance: Interacting
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```Gen
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episode: CaClearance
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contained_by: BEH-POST
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interacting: CaClearance
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contained_by: POSTSYNAPSE
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in_context: NOT bAP
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rf: ( active: 24x ) # Low
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@@ -206,7 +212,7 @@ Contestualizziamo in maniera Fixed?
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Qui controlliamo il livello di Ca2+, che e' stato fatto entrare da NMDA, e creaiamo VPost nel DB. Abbiamo fatto una semplificazione, perche' il Ca2+ dovrebbe entrare nel DB in base a V_Post che fa aprire canali in DB. Invece creaimo direttamente il VPost.
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```Gen
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context: CheckCaVPost
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context: CheckCaVPost ### DA ELIMINARE ###
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contained_by: BEH-POST
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in_context: Fixed
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@@ -222,23 +228,74 @@ context: CheckCaVPost
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out_context: CaLow
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```
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##### VPostMax:Episode
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##### VPostMax:Interacting
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##### VPostMed:Episode
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##### VPostMed:Interacting
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##### VPostMin:Episode
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##### VPostClearance:Episode
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##### VPostMin:Interacting
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##### VPostClearance:Interacting
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Il clearance lo facciamo qui nel container dove creaiamo anche i VPost, perche' altrimenti, se lo facessimo in DB, perderemmo l'aspetto temporale della contribuzione dei singoli POST.
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### sec: behaviors POST
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#### :Context
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## POST-AMPA: Container
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#### :Episode
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```Gen
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container: POST-AMPA
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tub_intricated:
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- NT ( contained_by: SYNAPSE )
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context_intricated:
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- Na ( contained_by: POSTSYNAPSE )
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```
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### ms: behaviors AMPA
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#### CheckNTPost: Context
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```Gen
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context: CheckNTPost ### DA ELIMINARE ###
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contained_by: POST-AMPA
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in_context: Fixed
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rf: ( active: 8x )
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condition: (NT mediumness)
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out_context: NTMedium
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condition: (NT fullness)
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out_context: NTFull
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```
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##### NaAMPAEnterMax: Interacting
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```Gen
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interacting: NaAMPAEnterMax
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contained_by: POST-AMPA
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in_context: Fixed
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rf: ( active: 2x )
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hypothesis: (NT fullness)
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action: [Na increase]
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trace:
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```
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##### NaAMPAEnterMed: Interacting
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```Gen
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interacting: NaAMPAEnterMed
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contained_by: POST-AMPA
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in_context: Fixed
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rf: ( active: 4x )
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hypothesis: (NT mediumness)
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action: [Na increase]
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trace:
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```
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### min: behaviors POST
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#### TUN-POST-AMPA: Tuner
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@@ -288,63 +345,6 @@ episode: ?
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trace:
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```
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## BEH-POST-AMPA: Container
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```Gen
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container: BEH-POST-AMPA
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tub_intricated:
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- Nt ( contained_by: BEH-SYN )
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context_intricated:
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- Na ( contained_by: BEH-POST )
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```
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### ms: behaviors AMPA
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#### CheckNTPost: Context
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```Gen
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context: CheckNTPost
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contained_by: BEH-POST-AMPA
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in_context: Fixed
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rf: ( active: 8x )
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condition: (NT mediumness)
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out_context: NTMedium
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condition: (NT fullness)
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out_context: NTFull
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```
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##### NaAMPAEnterMax: Episode
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```Gen
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episode: NaAMPAEnterMax
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contained_by: BEH-POST-AMPA
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in_context: NTFull
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rf: ( active: 2x )
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hypothesis: (NT fullness)
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action: [Na increase]
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trace:
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```
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##### NaAMPAEnterMed: Episode
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```Gen
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episode: NaAMPAEnterMed
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contained_by: BEH-POST-AMPA
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in_context: NTMedium
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rf: ( active: 4x )
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hypothesis: (NT mediumness)
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action: [Na increase]
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trace:
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```
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## BEH-POST-NA-CLEAR: Container
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