From a29010cc40d8b7c9f366d038d35905edeb126c02 Mon Sep 17 00:00:00 2001 From: Sergio Marchetti Date: Sun, 26 Apr 2026 12:38:41 +0000 Subject: [PATCH] Sergio --- neuron/postsynapse.md | 230 +++++++++++++++++++++--------------------- 1 file changed, 115 insertions(+), 115 deletions(-) diff --git a/neuron/postsynapse.md b/neuron/postsynapse.md index 829d00d..5b3d1c7 100644 --- a/neuron/postsynapse.md +++ b/neuron/postsynapse.md @@ -2,10 +2,10 @@ Qui comprendiamo: -- BEH-POST: Postsynapse -- BEH-POST-AMPA: AMPA receptors (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors) +- POSTSYNAPSE: Postsynapse +- POST-AMPA: AMPA receptors (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors) -## BEH-POST: Container +## POSTSYNAPSE: Container **Simplified Behaviors**: @@ -44,14 +44,13 @@ POSTSYNAPSE -- Ca Influx CaNDMAEnterMax: interacting CaNDMAEnterMed: interacting - -- Ca Clearence - AP-CaClearanceHigh: interacting - AP-CaClearanceMedium: interacting - NOT bAP_ctx: -- Ca Influx CaNDMAEnterMedNotBap: interacting CaNDMAEnterLow: interacting + -- Ca Clearence + CaClearance: interacting - Fixed?? -- V Influx @@ -61,17 +60,17 @@ POSTSYNAPSE -- V Clearence VPostClearance: interacting -POST-AMPA - - Fixed?? - -- Na Influx - NaAMPAEnterMax: interacting - NaAMPAEnterMed: interacting + POST-AMPA + - Fixed?? + -- Na Influx + NaAMPAEnterMax: interacting + NaAMPAEnterMed: interacting -POST-NA-CLEAR - - Fixed?? - -- Na Clearence - NaClearanceHigh: interacting - NaClearanceLow: interacting + POST-NA-CLEAR + - Fixed?? + -- Na Clearence + NaClearanceHigh: interacting + NaClearanceLow: interacting ``` @@ -79,43 +78,35 @@ POST-NA-CLEAR **Tubs:** - **Na**: Ioni entranti tramite AMPA receptors - - **NT**: - - **Ca2+**: Ioni entranti tramite NMDA - - **VPost**: il voltage che viene sentito in DB - - **eCB**: - - **Nox**:? --- ```Gen -container: BEH-POST +container: POSTSYNAPSE expansion: - POST-AMPA ( full: 10x, active: 5x, empty: 2x ) # modulated_by: TUN-POST-IC # possible/actual - - POST-NA-CLEAR ( full: 1x, active: 1x, empty: 0x ) + # modulated_by: ?? tub_local: - Ca2+ ( full: 60x, active: 30x, empty: 0x ) - - Na ( full: 60x, active: 30x, empty: 0x ) - - Nox ( full: 100x, active: 20x, empty: 0x ) # Nitric Oxide (NO): A gas that diffuses freely. - - eCB ( full: 100x, active: 20x, empty: 0x ) # Endocannabinoids (e.g., 2-AG) tub_intricated: - - Nt ( contained_by: BEH-SYN ) - - VPost ( contained_by: BEH-BD ) + - NT ( contained_by: SYNAPSE ) + - VPost ( contained_by: BD ) context_intricated: - - bAp ( contained_by: BEH-SOMA ) + - bAp ( contained_by: SOMA ) ``` ### ms: behaviors POST @@ -127,7 +118,7 @@ container: BEH-POST Contestualizziamo in maniera Fixed? ```Gen -context: CheckNa +context: CheckNa ## DA ELIMINARE ## contained_by: BEH-POST in_context: Fixed @@ -143,53 +134,68 @@ context: CheckNa out_context: NaLow ``` -##### CaNDMAEnterMax: Episode +##### CaNDMAEnterMax: Interacting ```Gen -episode: CaNDMAEnterMax - contained_by: BEH-POST +interacting: CaNDMAEnterMax + contained_by: POSTSYNAPSE - in_context: bAp AND (NaMax OR NaMedium) + in_context: bAp rf: ( active: 2x ) - hypothesis: NOT (Ca2+ full) + hypothesis: NOT (Ca2+ full) AND + (Na fullness OR Na mediumness) action: [Ca2+ increase] trace: ``` -##### CaNDMAEnterMed: Episode +##### CaNDMAEnterMed: Interacting ```Gen -episode: CaNDMAEnterMed - contained_by: BEH-POST +interacting: CaNDMAEnterMed + contained_by: POSTSYNAPSE - in_context: (bAp AND NaLow) OR (NOT bAP AND NaMax) + in_context: bAp rf: ( active: 4x ) - hypothesis: NOT (Ca2+ full) + hypothesis: NOT (Ca2+ full) AND (Na emptiness) action: [Ca2+ increase] trace: ``` -##### CaNDMAEnterLow: Episode +##### CaNDMAEnterMedNotBap: Interacting ```Gen -episode: CaNDMAEnterLow - contained_by: BEH-POST +interacting: CaNDMAEnterMedNotBap + contained_by: POSTSYNAPSE - in_context: NOT bAP AND NaMedium + in_context: NOT bAP + rf: ( active: 4x ) + + hypothesis: NOT (Ca2+ full) AND (Na fullness) + action: [Ca2+ increase] + trace: +``` + +##### CaNDMAEnterLow: Interacting + +```Gen +interacting: CaNDMAEnterLow + contained_by: POSTSYNAPSE + + in_context: NOT bAP rf: ( active: 12x ) - hypothesis: NOT (Ca2+ full) + hypothesis: NOT (Ca2+ full) AND (Na mediumness) action: [Ca2+ increase] trace: ``` -#### CaClearance: Episode +#### CaClearance: Interacting ```Gen -episode: CaClearance - contained_by: BEH-POST +interacting: CaClearance + contained_by: POSTSYNAPSE in_context: NOT bAP rf: ( active: 24x ) # Low @@ -206,7 +212,7 @@ Contestualizziamo in maniera Fixed? Qui controlliamo il livello di Ca2+, che e' stato fatto entrare da NMDA, e creaiamo VPost nel DB. Abbiamo fatto una semplificazione, perche' il Ca2+ dovrebbe entrare nel DB in base a V_Post che fa aprire canali in DB. Invece creaimo direttamente il VPost. ```Gen -context: CheckCaVPost +context: CheckCaVPost ### DA ELIMINARE ### contained_by: BEH-POST in_context: Fixed @@ -222,23 +228,74 @@ context: CheckCaVPost out_context: CaLow ``` -##### VPostMax:Episode +##### VPostMax:Interacting -##### VPostMed:Episode +##### VPostMed:Interacting -##### VPostMin:Episode - -##### VPostClearance:Episode +##### VPostMin:Interacting +##### VPostClearance:Interacting Il clearance lo facciamo qui nel container dove creaiamo anche i VPost, perche' altrimenti, se lo facessimo in DB, perderemmo l'aspetto temporale della contribuzione dei singoli POST. -### sec: behaviors POST -#### :Context +## POST-AMPA: Container -#### :Episode +```Gen +container: POST-AMPA + + tub_intricated: + - NT ( contained_by: SYNAPSE ) + + context_intricated: + - Na ( contained_by: POSTSYNAPSE ) +``` + +### ms: behaviors AMPA + +#### CheckNTPost: Context + +```Gen +context: CheckNTPost ### DA ELIMINARE ### + contained_by: POST-AMPA + + in_context: Fixed + rf: ( active: 8x ) + + condition: (NT mediumness) + out_context: NTMedium + + condition: (NT fullness) + out_context: NTFull +``` + +##### NaAMPAEnterMax: Interacting + +```Gen +interacting: NaAMPAEnterMax + contained_by: POST-AMPA + + in_context: Fixed + rf: ( active: 2x ) + + hypothesis: (NT fullness) + action: [Na increase] + trace: +``` + +##### NaAMPAEnterMed: Interacting + +```Gen +interacting: NaAMPAEnterMed + contained_by: POST-AMPA + + in_context: Fixed + rf: ( active: 4x ) + + hypothesis: (NT mediumness) + action: [Na increase] + trace: +``` -### min: behaviors POST #### TUN-POST-AMPA: Tuner @@ -288,63 +345,6 @@ episode: ? trace: ``` -## BEH-POST-AMPA: Container - -```Gen -container: BEH-POST-AMPA - - tub_intricated: - - Nt ( contained_by: BEH-SYN ) - - context_intricated: - - Na ( contained_by: BEH-POST ) -``` - -### ms: behaviors AMPA - -#### CheckNTPost: Context - -```Gen -context: CheckNTPost - contained_by: BEH-POST-AMPA - - in_context: Fixed - rf: ( active: 8x ) - - condition: (NT mediumness) - out_context: NTMedium - - condition: (NT fullness) - out_context: NTFull -``` - -##### NaAMPAEnterMax: Episode - -```Gen -episode: NaAMPAEnterMax - contained_by: BEH-POST-AMPA - - in_context: NTFull - rf: ( active: 2x ) - - hypothesis: (NT fullness) - action: [Na increase] - trace: -``` - -##### NaAMPAEnterMed: Episode - -```Gen -episode: NaAMPAEnterMed - contained_by: BEH-POST-AMPA - - in_context: NTMedium - rf: ( active: 4x ) - - hypothesis: (NT mediumness) - action: [Na increase] - trace: -``` ## BEH-POST-NA-CLEAR: Container