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Sergio

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Sergio Marchetti
2026-04-26 12:38:41 +00:00
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neuron/postsynapse.md
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@@ -2,10 +2,10 @@
Qui comprendiamo: Qui comprendiamo:
- BEH-POST: Postsynapse - POSTSYNAPSE: Postsynapse
- BEH-POST-AMPA: AMPA receptors (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors) - POST-AMPA: AMPA receptors (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors)
## BEH-POST: Container ## POSTSYNAPSE: Container
**Simplified Behaviors**: **Simplified Behaviors**:
@@ -44,14 +44,13 @@ POSTSYNAPSE
-- Ca Influx -- Ca Influx
CaNDMAEnterMax: interacting CaNDMAEnterMax: interacting
CaNDMAEnterMed: interacting CaNDMAEnterMed: interacting
-- Ca Clearence
AP-CaClearanceHigh: interacting
AP-CaClearanceMedium: interacting
- NOT bAP_ctx: - NOT bAP_ctx:
-- Ca Influx -- Ca Influx
CaNDMAEnterMedNotBap: interacting CaNDMAEnterMedNotBap: interacting
CaNDMAEnterLow: interacting CaNDMAEnterLow: interacting
-- Ca Clearence
CaClearance: interacting
- Fixed?? - Fixed??
-- V Influx -- V Influx
@@ -61,17 +60,17 @@ POSTSYNAPSE
-- V Clearence -- V Clearence
VPostClearance: interacting VPostClearance: interacting
POST-AMPA POST-AMPA
- Fixed?? - Fixed??
-- Na Influx -- Na Influx
NaAMPAEnterMax: interacting NaAMPAEnterMax: interacting
NaAMPAEnterMed: interacting NaAMPAEnterMed: interacting
POST-NA-CLEAR POST-NA-CLEAR
- Fixed?? - Fixed??
-- Na Clearence -- Na Clearence
NaClearanceHigh: interacting NaClearanceHigh: interacting
NaClearanceLow: interacting NaClearanceLow: interacting
``` ```
@@ -79,43 +78,35 @@ POST-NA-CLEAR
**Tubs:** **Tubs:**
- **Na**: Ioni entranti tramite AMPA receptors - **Na**: Ioni entranti tramite AMPA receptors
- **NT**: - **NT**:
- **Ca2+**: Ioni entranti tramite NMDA - **Ca2+**: Ioni entranti tramite NMDA
- **VPost**: il voltage che viene sentito in DB - **VPost**: il voltage che viene sentito in DB
- **eCB**: - **eCB**:
- **Nox**:? - **Nox**:?
--- ---
```Gen ```Gen
container: BEH-POST container: POSTSYNAPSE
expansion: expansion:
- POST-AMPA ( full: 10x, active: 5x, empty: 2x ) - POST-AMPA ( full: 10x, active: 5x, empty: 2x )
# modulated_by: TUN-POST-IC # possible/actual # modulated_by: TUN-POST-IC # possible/actual
- POST-NA-CLEAR ( full: 1x, active: 1x, empty: 0x ) - POST-NA-CLEAR ( full: 1x, active: 1x, empty: 0x )
# modulated_by: ??
tub_local: tub_local:
- Ca2+ ( full: 60x, active: 30x, empty: 0x ) - Ca2+ ( full: 60x, active: 30x, empty: 0x )
- Na ( full: 60x, active: 30x, empty: 0x ) - Na ( full: 60x, active: 30x, empty: 0x )
- Nox ( full: 100x, active: 20x, empty: 0x ) # Nitric Oxide (NO): A gas that diffuses freely. - Nox ( full: 100x, active: 20x, empty: 0x ) # Nitric Oxide (NO): A gas that diffuses freely.
- eCB ( full: 100x, active: 20x, empty: 0x ) # Endocannabinoids (e.g., 2-AG) - eCB ( full: 100x, active: 20x, empty: 0x ) # Endocannabinoids (e.g., 2-AG)
tub_intricated: tub_intricated:
- Nt ( contained_by: BEH-SYN ) - NT ( contained_by: SYNAPSE )
- VPost ( contained_by: BEH-BD ) - VPost ( contained_by: BD )
context_intricated: context_intricated:
- bAp ( contained_by: BEH-SOMA ) - bAp ( contained_by: SOMA )
``` ```
### ms: behaviors POST ### ms: behaviors POST
@@ -127,7 +118,7 @@ container: BEH-POST
Contestualizziamo in maniera Fixed? Contestualizziamo in maniera Fixed?
```Gen ```Gen
context: CheckNa context: CheckNa ## DA ELIMINARE ##
contained_by: BEH-POST contained_by: BEH-POST
in_context: Fixed in_context: Fixed
@@ -143,53 +134,68 @@ context: CheckNa
out_context: NaLow out_context: NaLow
``` ```
##### CaNDMAEnterMax: Episode ##### CaNDMAEnterMax: Interacting
```Gen ```Gen
episode: CaNDMAEnterMax interacting: CaNDMAEnterMax
contained_by: BEH-POST contained_by: POSTSYNAPSE
in_context: bAp AND (NaMax OR NaMedium) in_context: bAp
rf: ( active: 2x ) rf: ( active: 2x )
hypothesis: NOT (Ca2+ full) hypothesis: NOT (Ca2+ full) AND
(Na fullness OR Na mediumness)
action: [Ca2+ increase] action: [Ca2+ increase]
trace: trace:
``` ```
##### CaNDMAEnterMed: Episode ##### CaNDMAEnterMed: Interacting
```Gen ```Gen
episode: CaNDMAEnterMed interacting: CaNDMAEnterMed
contained_by: BEH-POST contained_by: POSTSYNAPSE
in_context: (bAp AND NaLow) OR (NOT bAP AND NaMax) in_context: bAp
rf: ( active: 4x ) rf: ( active: 4x )
hypothesis: NOT (Ca2+ full) hypothesis: NOT (Ca2+ full) AND (Na emptiness)
action: [Ca2+ increase] action: [Ca2+ increase]
trace: trace:
``` ```
##### CaNDMAEnterLow: Episode ##### CaNDMAEnterMedNotBap: Interacting
```Gen ```Gen
episode: CaNDMAEnterLow interacting: CaNDMAEnterMedNotBap
contained_by: BEH-POST contained_by: POSTSYNAPSE
in_context: NOT bAP AND NaMedium in_context: NOT bAP
rf: ( active: 4x )
hypothesis: NOT (Ca2+ full) AND (Na fullness)
action: [Ca2+ increase]
trace:
```
##### CaNDMAEnterLow: Interacting
```Gen
interacting: CaNDMAEnterLow
contained_by: POSTSYNAPSE
in_context: NOT bAP
rf: ( active: 12x ) rf: ( active: 12x )
hypothesis: NOT (Ca2+ full) hypothesis: NOT (Ca2+ full) AND (Na mediumness)
action: [Ca2+ increase] action: [Ca2+ increase]
trace: trace:
``` ```
#### CaClearance: Episode #### CaClearance: Interacting
```Gen ```Gen
episode: CaClearance interacting: CaClearance
contained_by: BEH-POST contained_by: POSTSYNAPSE
in_context: NOT bAP in_context: NOT bAP
rf: ( active: 24x ) # Low rf: ( active: 24x ) # Low
@@ -206,7 +212,7 @@ Contestualizziamo in maniera Fixed?
Qui controlliamo il livello di Ca2+, che e' stato fatto entrare da NMDA, e creaiamo VPost nel DB. Abbiamo fatto una semplificazione, perche' il Ca2+ dovrebbe entrare nel DB in base a V_Post che fa aprire canali in DB. Invece creaimo direttamente il VPost. Qui controlliamo il livello di Ca2+, che e' stato fatto entrare da NMDA, e creaiamo VPost nel DB. Abbiamo fatto una semplificazione, perche' il Ca2+ dovrebbe entrare nel DB in base a V_Post che fa aprire canali in DB. Invece creaimo direttamente il VPost.
```Gen ```Gen
context: CheckCaVPost context: CheckCaVPost ### DA ELIMINARE ###
contained_by: BEH-POST contained_by: BEH-POST
in_context: Fixed in_context: Fixed
@@ -222,23 +228,74 @@ context: CheckCaVPost
out_context: CaLow out_context: CaLow
``` ```
##### VPostMax:Episode ##### VPostMax:Interacting
##### VPostMed:Episode ##### VPostMed:Interacting
##### VPostMin:Episode ##### VPostMin:Interacting
##### VPostClearance:Episode
##### VPostClearance:Interacting
Il clearance lo facciamo qui nel container dove creaiamo anche i VPost, perche' altrimenti, se lo facessimo in DB, perderemmo l'aspetto temporale della contribuzione dei singoli POST. Il clearance lo facciamo qui nel container dove creaiamo anche i VPost, perche' altrimenti, se lo facessimo in DB, perderemmo l'aspetto temporale della contribuzione dei singoli POST.
### sec: behaviors POST
#### :Context ## POST-AMPA: Container
#### :Episode ```Gen
container: POST-AMPA
tub_intricated:
- NT ( contained_by: SYNAPSE )
context_intricated:
- Na ( contained_by: POSTSYNAPSE )
```
### ms: behaviors AMPA
#### CheckNTPost: Context
```Gen
context: CheckNTPost ### DA ELIMINARE ###
contained_by: POST-AMPA
in_context: Fixed
rf: ( active: 8x )
condition: (NT mediumness)
out_context: NTMedium
condition: (NT fullness)
out_context: NTFull
```
##### NaAMPAEnterMax: Interacting
```Gen
interacting: NaAMPAEnterMax
contained_by: POST-AMPA
in_context: Fixed
rf: ( active: 2x )
hypothesis: (NT fullness)
action: [Na increase]
trace:
```
##### NaAMPAEnterMed: Interacting
```Gen
interacting: NaAMPAEnterMed
contained_by: POST-AMPA
in_context: Fixed
rf: ( active: 4x )
hypothesis: (NT mediumness)
action: [Na increase]
trace:
```
### min: behaviors POST
#### TUN-POST-AMPA: Tuner #### TUN-POST-AMPA: Tuner
@@ -288,63 +345,6 @@ episode: ?
trace: trace:
``` ```
## BEH-POST-AMPA: Container
```Gen
container: BEH-POST-AMPA
tub_intricated:
- Nt ( contained_by: BEH-SYN )
context_intricated:
- Na ( contained_by: BEH-POST )
```
### ms: behaviors AMPA
#### CheckNTPost: Context
```Gen
context: CheckNTPost
contained_by: BEH-POST-AMPA
in_context: Fixed
rf: ( active: 8x )
condition: (NT mediumness)
out_context: NTMedium
condition: (NT fullness)
out_context: NTFull
```
##### NaAMPAEnterMax: Episode
```Gen
episode: NaAMPAEnterMax
contained_by: BEH-POST-AMPA
in_context: NTFull
rf: ( active: 2x )
hypothesis: (NT fullness)
action: [Na increase]
trace:
```
##### NaAMPAEnterMed: Episode
```Gen
episode: NaAMPAEnterMed
contained_by: BEH-POST-AMPA
in_context: NTMedium
rf: ( active: 4x )
hypothesis: (NT mediumness)
action: [Na increase]
trace:
```
## BEH-POST-NA-CLEAR: Container ## BEH-POST-NA-CLEAR: Container