Sergio

neuron/postsynapse.md

@@ -2,10 +2,10 @@
 
 Qui comprendiamo:
 
-- BEH-POST: Postsynapse
+- POSTSYNAPSE: Postsynapse
-- BEH-POST-AMPA: AMPA receptors (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors)
+- POST-AMPA: AMPA receptors (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors)
 
-## BEH-POST: Container
+## POSTSYNAPSE: Container
 
 **Simplified Behaviors**:
 
@@ -44,14 +44,13 @@ POSTSYNAPSE
     -- Ca Influx
     CaNDMAEnterMax: interacting 
     CaNDMAEnterMed: interacting
-    -- Ca Clearence
-    AP-CaClearanceHigh: interacting
-    AP-CaClearanceMedium: interacting
 
   - NOT bAP_ctx:
     -- Ca Influx
     CaNDMAEnterMedNotBap: interacting
     CaNDMAEnterLow: interacting
+    -- Ca Clearence
+    CaClearance: interacting
 
   - Fixed??
     -- V Influx
@@ -79,43 +78,35 @@ POST-NA-CLEAR
 **Tubs:**
 
 - **Na**: Ioni entranti tramite AMPA receptors
-
 - **NT**:
-
 - **Ca2+**: Ioni entranti tramite NMDA
-
 - **VPost**: il voltage che viene sentito in DB
-
 - **eCB**:
-
 - **Nox**:?
 
 ---
 
 ```Gen
-container: BEH-POST
+container: POSTSYNAPSE
 
  expansion: 
   - POST-AMPA ( full: 10x, active: 5x, empty: 2x )
    # modulated_by: TUN-POST-IC # possible/actual
-
   - POST-NA-CLEAR ( full: 1x, active: 1x, empty: 0x )
+   # modulated_by: ??
 
  tub_local:
   - Ca2+ ( full: 60x, active: 30x, empty: 0x )
-
   - Na ( full: 60x, active: 30x, empty: 0x )
-
   - Nox ( full: 100x, active: 20x, empty: 0x ) # Nitric Oxide (NO):  A gas that diffuses freely.
-
   - eCB ( full: 100x, active: 20x, empty: 0x ) # Endocannabinoids (e.g., 2-AG)
 
  tub_intricated:
-  - Nt ( contained_by: BEH-SYN )
+  - NT ( contained_by: SYNAPSE )
-  - VPost ( contained_by: BEH-BD )
+  - VPost ( contained_by: BD )
 
  context_intricated:
-  - bAp ( contained_by: BEH-SOMA )
+  - bAp ( contained_by: SOMA )
 ```
 
 ### ms: behaviors POST
@@ -127,7 +118,7 @@ container: BEH-POST
 Contestualizziamo in maniera Fixed?
 
 ```Gen
-context: CheckNa
+context: CheckNa ## DA ELIMINARE ##
   contained_by: BEH-POST
 
   in_context: Fixed
@@ -143,53 +134,68 @@ context: CheckNa
     out_context: NaLow
 ```
 
-##### CaNDMAEnterMax: Episode
+##### CaNDMAEnterMax: Interacting
 
 ```Gen
-episode: CaNDMAEnterMax
+interacting: CaNDMAEnterMax
-  contained_by: BEH-POST
+  contained_by: POSTSYNAPSE
 
-  in_context: bAp AND (NaMax OR NaMedium)
+  in_context: bAp
   rf: ( active: 2x )
 
- hypothesis: NOT (Ca2+ full)
+ hypothesis: NOT (Ca2+ full) AND
+            (Na fullness OR Na mediumness)
   action: [Ca2+ increase]
   trace: 
 ```
 
-##### CaNDMAEnterMed: Episode
+##### CaNDMAEnterMed: Interacting
 
 ```Gen
-episode: CaNDMAEnterMed
+interacting: CaNDMAEnterMed
-  contained_by: BEH-POST
+  contained_by: POSTSYNAPSE
 
-  in_context: (bAp AND NaLow) OR (NOT bAP AND NaMax) 
+  in_context: bAp 
   rf: ( active: 4x )
 
- hypothesis: NOT (Ca2+ full)
+ hypothesis: NOT (Ca2+ full) AND (Na emptiness)
   action: [Ca2+ increase]
   trace: 
 ```
 
-##### CaNDMAEnterLow: Episode
+##### CaNDMAEnterMedNotBap: Interacting
 
 ```Gen
-episode: CaNDMAEnterLow
+interacting: CaNDMAEnterMedNotBap
-  contained_by: BEH-POST
+  contained_by: POSTSYNAPSE
 
-  in_context: NOT bAP AND NaMedium 
+  in_context: NOT bAP 
+  rf: ( active: 4x )
+
+ hypothesis: NOT (Ca2+ full) AND (Na fullness)
+  action: [Ca2+ increase]
+  trace: 
+```
+
+##### CaNDMAEnterLow: Interacting
+
+```Gen
+interacting: CaNDMAEnterLow
+  contained_by: POSTSYNAPSE
+
+  in_context: NOT bAP 
   rf: ( active: 12x )
 
-  hypothesis: NOT (Ca2+ full)
+  hypothesis: NOT (Ca2+ full) AND (Na mediumness)
     action: [Ca2+ increase]
     trace: 
 ```
 
-#### CaClearance: Episode
+#### CaClearance: Interacting
 
 ```Gen
-episode: CaClearance
+interacting: CaClearance
-  contained_by: BEH-POST
+  contained_by: POSTSYNAPSE
 
   in_context: NOT bAP
   rf: ( active: 24x ) # Low
@@ -206,7 +212,7 @@ Contestualizziamo in maniera Fixed?
 Qui controlliamo il livello di Ca2+, che e' stato fatto entrare da NMDA, e creaiamo VPost nel DB. Abbiamo fatto una semplificazione, perche' il Ca2+ dovrebbe entrare nel DB in base a V_Post che fa aprire canali in DB. Invece creaimo direttamente il VPost.
 
 ```Gen
-context: CheckCaVPost
+context: CheckCaVPost ### DA ELIMINARE ###
   contained_by: BEH-POST
 
   in_context: Fixed
@@ -222,23 +228,74 @@ context: CheckCaVPost
     out_context: CaLow
 ```
 
-##### VPostMax:Episode
+##### VPostMax:Interacting
 
-##### VPostMed:Episode
+##### VPostMed:Interacting
 
-##### VPostMin:Episode
+##### VPostMin:Interacting
-
-##### VPostClearance:Episode
 
+##### VPostClearance:Interacting
 Il clearance lo facciamo qui nel container dove creaiamo anche i VPost, perche' altrimenti, se lo facessimo in DB, perderemmo l'aspetto temporale della contribuzione dei singoli POST.
 
-### sec: behaviors POST
 
-#### :Context
+## POST-AMPA: Container
 
-#### :Episode
+```Gen
+container: POST-AMPA
+
+ tub_intricated:
+  - NT ( contained_by: SYNAPSE )
+
+ context_intricated:
+  - Na ( contained_by: POSTSYNAPSE )
+```
+
+### ms: behaviors AMPA
+
+#### CheckNTPost: Context
+
+```Gen
+context: CheckNTPost ### DA ELIMINARE ###
+  contained_by: POST-AMPA
+
+  in_context: Fixed
+  rf: ( active: 8x )
+
+  condition: (NT mediumness) 
+    out_context: NTMedium
+
+  condition: (NT fullness) 
+    out_context: NTFull
+```
+
+##### NaAMPAEnterMax: Interacting
+
+```Gen
+interacting: NaAMPAEnterMax
+  contained_by: POST-AMPA
+
+  in_context: Fixed
+  rf: ( active: 2x )
+
+ hypothesis: (NT fullness)
+  action: [Na increase]
+  trace: 
+```
+
+##### NaAMPAEnterMed: Interacting
+
+```Gen
+interacting: NaAMPAEnterMed
+  contained_by: POST-AMPA
+
+  in_context: Fixed
+  rf: ( active: 4x )
+
+ hypothesis: (NT mediumness)
+  action: [Na increase]
+  trace: 
+```
 
-### min: behaviors POST
 
 #### TUN-POST-AMPA: Tuner
 
@@ -288,63 +345,6 @@ episode: ?
   trace: 
 ```
 
-## BEH-POST-AMPA: Container
-
-```Gen
-container: BEH-POST-AMPA
-
- tub_intricated:
-  - Nt ( contained_by: BEH-SYN )
-
- context_intricated:
-  - Na ( contained_by: BEH-POST )
-```
-
-### ms: behaviors AMPA
-
-#### CheckNTPost: Context
-
-```Gen
-context: CheckNTPost
-  contained_by: BEH-POST-AMPA
-
-  in_context: Fixed
-  rf: ( active: 8x )
-
-  condition: (NT mediumness) 
-    out_context: NTMedium
-
-  condition: (NT fullness) 
-    out_context: NTFull
-```
-
-##### NaAMPAEnterMax: Episode
-
-```Gen
-episode: NaAMPAEnterMax
-  contained_by: BEH-POST-AMPA
-
-  in_context: NTFull
-  rf: ( active: 2x )
-
- hypothesis: (NT fullness)
-  action: [Na increase]
-  trace: 
-```
-
-##### NaAMPAEnterMed: Episode
-
-```Gen
-episode: NaAMPAEnterMed
-  contained_by: BEH-POST-AMPA
-
-  in_context: NTMedium
-  rf: ( active: 4x )
-
- hypothesis: (NT mediumness)
-  action: [Na increase]
-  trace: 
-```
 
 ## BEH-POST-NA-CLEAR: Container