alcuni sniplet Soma e indentation

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2026-04-10 11:35:39 +02:00
parent 59bd854a1c
commit 94c8a25b31
3 changed files with 95 additions and 65 deletions
+3 -3
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@@ -120,7 +120,7 @@ context: CheckVPost
out_context: VPostLow out_context: VPostLow
``` ```
#### VDBMax: Episode ##### VDBMax: Episode
```Gen ```Gen
episode: VDBMax episode: VDBMax
@@ -134,7 +134,7 @@ episode: VDBMax
trace: trace:
``` ```
#### VDBMed: Episode ##### VDBMed: Episode
```Gen ```Gen
episode: VDBMed episode: VDBMed
@@ -148,7 +148,7 @@ episode: VDBMed
trace: trace:
``` ```
#### VDBLow: Episode ##### VDBLow: Episode
```Gen ```Gen
episode: VDBLow episode: VDBLow
+7 -9
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@@ -195,7 +195,7 @@ container: BEH-POST
![post-ltp-ltd.png](.attachments/post-ltp-ltd.png) ![post-ltp-ltd.png](.attachments/post-ltp-ltd.png)
#### CheckNa:Context #### CheckNa: Context
Contestualizziamo in maniera Fixed? Contestualizziamo in maniera Fixed?
@@ -216,7 +216,7 @@ context: CheckNa
out_context: NaLow out_context: NaLow
``` ```
#### CaNDMAEnterMax: Episode ##### CaNDMAEnterMax: Episode
```Gen ```Gen
episode: CaNDMAEnterMax episode: CaNDMAEnterMax
@@ -230,7 +230,7 @@ episode: CaNDMAEnterMax
trace: trace:
``` ```
#### CaNDMAEnterMed: Episode ##### CaNDMAEnterMed: Episode
```Gen ```Gen
episode: CaNDMAEnterMed episode: CaNDMAEnterMed
@@ -244,7 +244,7 @@ episode: CaNDMAEnterMed
trace: trace:
``` ```
#### CaNDMAEnterLow: Episode ##### CaNDMAEnterLow: Episode
```Gen ```Gen
episode: CaNDMAEnterLow episode: CaNDMAEnterLow
@@ -258,9 +258,7 @@ episode: CaNDMAEnterLow
trace: trace:
``` ```
#### CaClearance #### CaClearance: Episode
##### CaClearance: Episode
```Gen ```Gen
episode: CaClearance episode: CaClearance
@@ -345,7 +343,7 @@ context: CheckNTPost
out_context: NTFull out_context: NTFull
``` ```
#### NaAMPAEnterMax: Episode ##### NaAMPAEnterMax: Episode
```Gen ```Gen
episode: NaAMPAEnterMax episode: NaAMPAEnterMax
@@ -359,7 +357,7 @@ episode: NaAMPAEnterMax
trace: trace:
``` ```
#### NaAMPAEnterMed: Episode ##### NaAMPAEnterMed: Episode
```Gen ```Gen
episode: NaAMPAEnterMed episode: NaAMPAEnterMed
+85 -53
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@@ -33,6 +33,18 @@ The soma does not fire randomly or continuously. Under no input it sits at rest,
The soma is therefore not a simple threshold device. It is a dynamic integrator with memory encoded in its current membrane potential, a nonlinear decision mechanism encoded in its channel kinetics, a refractory mechanism that shapes its temporal output, and a metabolic dependence that links its firing capacity to the health of its local environment. It is, in miniature, a complete signal processing unit — and the action potential it produces is the one binary output that all of this continuous analogue computation ultimately reduces to. The soma is therefore not a simple threshold device. It is a dynamic integrator with memory encoded in its current membrane potential, a nonlinear decision mechanism encoded in its channel kinetics, a refractory mechanism that shapes its temporal output, and a metabolic dependence that links its firing capacity to the health of its local environment. It is, in miniature, a complete signal processing unit — and the action potential it produces is the one binary output that all of this continuous analogue computation ultimately reduces to.
Event Time Scale Responsible Mechanism
─────────────────────────────────────────────────────────────────
Resting at -70 mV steady Leak channels + pumps (balance)
Depolarization to -50 mV ~1-2 ms Na⁺ enters (VGSCs open)
Repolarization to -70 mV ~1-2 ms K⁺ exits (VG K⁺ channels open) ← NOT pumps!
After-hyperpolarization ~5-20 ms K⁺ channels still open
Return to exact -70 mV ~100-1000 ms Na⁺/K⁺ pumps restore gradients
--- ---
**Simplified comprehension**: **Simplified comprehension**:
@@ -60,48 +72,28 @@ ATP is a simplification of convenience — at this stage we do not comprehend th
— ms: — ms:
- VDB is integrated (each Dendrites acts as leaky integrator)
- Threshold check - condition VDB fullness - (only when not in AP waveform phase and not in absolute refractory)
-- AP
-- bAP
-- VSOMA
--- tau_AP_rise = 0.5 ms - Na⁺ channels open — explosive depolarisation
--- (tau_AP_fall = 1.5 ms) - VSOMA falls toward V_AHP - K⁺ channels open — repolarisation
--- (tau_AHP = 5.0 ms) - VSOMA recovers from V_AHP toward VSOMA_reset - K⁺ channels close — after-hyperpolarisation
- V_bAP as a context is active during ?
- SpikeTrainTraces ?
-- creation
-- destruction
- SOMA-VCGG servono a modificare il comportamento del SOMA: refractory period.
- threshold AP: da capire come lo modifico, forse con una modifica ad una fullness
— seconds: — seconds:
- nothing — no slow integration in the soma - Ca2+ accumulation: SpikeTrainTraces
(firing rate statistics could be computed here as a diagnostic
but they do not feed back into any other variable)
— mins: — mins:
- nothing in the simplified model - VGSC modulation
(homeostatic threshold regulation would live here if added:
sustained low firing rate → VSOMA_threshold decreases
sustained high firing rate → VSOMA_threshold increases
this is the somatic equivalent of postsynaptic AMPA scaling —
the neuron adjusts its own excitability to maintain a target
firing rate in the face of changing input statistics)
--- ---
**Tubs:** **Tubs:**
- **SpikeTrainTraces**: sono le tracce che consentono al neurone di far partire il Tuning neuronale, quando e' lontano da uno spike-train, ovvero e' in riposo. - **VDB**: dendrites deliver current
- **??**: ... - **VSOMA**: are a proxy for the Coulombs of charge building up on the somatic membrane.
- **AP**:
- **bAP**:
- **SpikeTrainTraces**: sono le tracce che consentono al neurone di far partire il Tuning neuronale, quando e' lontano da uno spike-train, ovvero e' in riposo.
--- ---
@@ -126,36 +118,74 @@ container: BEH-SOMA
- SpikeTrainTraces ( contained_by: TUN-N ) - SpikeTrainTraces ( contained_by: TUN-N )
``` ```
## : Context ### ms: behaviors SOMA
Qui mettiamo lo spike Dendritico. Sempre se vogliamo comprenderlo. #### CheckVDB: Context
As dendrites deliver current (VDB), the soma acts like a capacitor. It "stores" this charge in the form of membrane potential. VSOMA is proxy for the Coulombs of charge building up on the somatic membrane.
Contestualizziamo in maniera Fixed?
```Gen ```Gen
context: ???... context: CheckVDB
contained_by: BEH-SOMA
in_context: Fixed
rf: 60x
condition:
activate: xxx
```
## : Episode
```Gen
episode: ??
contained_by: BEH-SOMA contained_by: BEH-SOMA
in_context: xxx in_context: Fixed
rf: ( active: 1x ) rf: ( active: 60x )
hypothesis: condition: (VDB fullness)
action: out_context: VDBMax
trace: None
condition: (VDB mediumness)
out_context: VDBMedium
condition: (VDB emptiness)
out_context: VDBLow
``` ```
## BEH-SOMA-VCGG: Container ##### VDBMax: Episode
```Gen
episode: VDBMax
contained_by: BEH-SOMA
in_context: VDBMax
rf: ( active: 2x )
hypothesis: NOT (VSOMA full)
action: [VSOMA increase]
trace:
```
##### VDBMed: Episode
```Gen
episode: VDBMed
contained_by: BEH-SOMA
in_context: VDBMedium
rf: ( active: 4x )
hypothesis: NOT (VSOMA full)
action: [VSOMA increase]
trace:
```
##### VDBLow: Episode
```Gen
episode: VDBLow
contained_by: BEH-SOMA
in_context: VDBLow
rf: ( active: 8x )
hypothesis: NOT (VSOMA full)
action: [VSOMA increase]
trace:
```
## BEH-SOMA-VGSC: Container
Voltage Gated Sodium Channel Voltage Gated Sodium Channel
@@ -164,7 +194,9 @@ container: BEH-SOMA-VGSC
``` ```
### Episode1 ### ms: behaviors SOMA-VGSC
#### Episode1
```Gen ```Gen
episode: ?? episode: ??