From 94c8a25b31e047425af76c6ed975d57df6b67d33 Mon Sep 17 00:00:00 2001 From: ocrampal Date: Fri, 10 Apr 2026 11:35:39 +0200 Subject: [PATCH] alcuni sniplet Soma e indentation --- neuron/BEH-BD.md | 6 +- neuron/BEH-POST.md | 16 +++--- neuron/BEH-SOMA.md | 138 ++++++++++++++++++++++++++++----------------- 3 files changed, 95 insertions(+), 65 deletions(-) diff --git a/neuron/BEH-BD.md b/neuron/BEH-BD.md index fbbc2e3..161733f 100644 --- a/neuron/BEH-BD.md +++ b/neuron/BEH-BD.md @@ -120,7 +120,7 @@ context: CheckVPost out_context: VPostLow ``` -#### VDBMax: Episode +##### VDBMax: Episode ```Gen episode: VDBMax @@ -134,7 +134,7 @@ episode: VDBMax trace: ``` -#### VDBMed: Episode +##### VDBMed: Episode ```Gen episode: VDBMed @@ -148,7 +148,7 @@ episode: VDBMed trace: ``` -#### VDBLow: Episode +##### VDBLow: Episode ```Gen episode: VDBLow diff --git a/neuron/BEH-POST.md b/neuron/BEH-POST.md index 1eca2e9..a43a4dc 100644 --- a/neuron/BEH-POST.md +++ b/neuron/BEH-POST.md @@ -195,7 +195,7 @@ container: BEH-POST ![post-ltp-ltd.png](.attachments/post-ltp-ltd.png) -#### CheckNa:Context +#### CheckNa: Context Contestualizziamo in maniera Fixed? @@ -216,7 +216,7 @@ context: CheckNa out_context: NaLow ``` -#### CaNDMAEnterMax: Episode +##### CaNDMAEnterMax: Episode ```Gen episode: CaNDMAEnterMax @@ -230,7 +230,7 @@ episode: CaNDMAEnterMax trace: ``` -#### CaNDMAEnterMed: Episode +##### CaNDMAEnterMed: Episode ```Gen episode: CaNDMAEnterMed @@ -244,7 +244,7 @@ episode: CaNDMAEnterMed trace: ``` -#### CaNDMAEnterLow: Episode +##### CaNDMAEnterLow: Episode ```Gen episode: CaNDMAEnterLow @@ -258,9 +258,7 @@ episode: CaNDMAEnterLow trace: ``` -#### CaClearance - -##### CaClearance: Episode +#### CaClearance: Episode ```Gen episode: CaClearance @@ -345,7 +343,7 @@ context: CheckNTPost out_context: NTFull ``` -#### NaAMPAEnterMax: Episode +##### NaAMPAEnterMax: Episode ```Gen episode: NaAMPAEnterMax @@ -359,7 +357,7 @@ episode: NaAMPAEnterMax trace: ``` -#### NaAMPAEnterMed: Episode +##### NaAMPAEnterMed: Episode ```Gen episode: NaAMPAEnterMed diff --git a/neuron/BEH-SOMA.md b/neuron/BEH-SOMA.md index 626a5ef..53e8feb 100644 --- a/neuron/BEH-SOMA.md +++ b/neuron/BEH-SOMA.md @@ -33,6 +33,18 @@ The soma does not fire randomly or continuously. Under no input it sits at rest, The soma is therefore not a simple threshold device. It is a dynamic integrator with memory encoded in its current membrane potential, a nonlinear decision mechanism encoded in its channel kinetics, a refractory mechanism that shapes its temporal output, and a metabolic dependence that links its firing capacity to the health of its local environment. It is, in miniature, a complete signal processing unit — and the action potential it produces is the one binary output that all of this continuous analogue computation ultimately reduces to. +Event Time Scale Responsible Mechanism +───────────────────────────────────────────────────────────────── +Resting at -70 mV steady Leak channels + pumps (balance) + ↓ +Depolarization to -50 mV ~1-2 ms Na⁺ enters (VGSCs open) + ↓ +Repolarization to -70 mV ~1-2 ms K⁺ exits (VG K⁺ channels open) ← NOT pumps! + ↓ +After-hyperpolarization ~5-20 ms K⁺ channels still open + ↓ +Return to exact -70 mV ~100-1000 ms Na⁺/K⁺ pumps restore gradients + --- **Simplified comprehension**: @@ -60,48 +72,28 @@ ATP is a simplification of convenience — at this stage we do not comprehend th — ms: -- VDB is integrated (each Dendrites acts as leaky integrator) -- Threshold check - condition VDB fullness - (only when not in AP waveform phase and not in absolute refractory) --- AP --- bAP --- VSOMA ---- tau_AP_rise = 0.5 ms - Na⁺ channels open — explosive depolarisation ---- (tau_AP_fall = 1.5 ms) - VSOMA falls toward V_AHP - K⁺ channels open — repolarisation ---- (tau_AHP = 5.0 ms) - VSOMA recovers from V_AHP toward VSOMA_reset - K⁺ channels close — after-hyperpolarisation - -- V_bAP as a context is active during ? - -- SpikeTrainTraces ? --- creation --- destruction - -- SOMA-VCGG servono a modificare il comportamento del SOMA: refractory period. - -- threshold AP: da capire come lo modifico, forse con una modifica ad una fullness — seconds: -- nothing — no slow integration in the soma - (firing rate statistics could be computed here as a diagnostic - but they do not feed back into any other variable) +- Ca2+ accumulation: SpikeTrainTraces — mins: -- nothing in the simplified model - (homeostatic threshold regulation would live here if added: - sustained low firing rate → VSOMA_threshold decreases - sustained high firing rate → VSOMA_threshold increases - this is the somatic equivalent of postsynaptic AMPA scaling — - the neuron adjusts its own excitability to maintain a target - firing rate in the face of changing input statistics) +- VGSC modulation --- **Tubs:** -- **SpikeTrainTraces**: sono le tracce che consentono al neurone di far partire il Tuning neuronale, quando e' lontano da uno spike-train, ovvero e' in riposo. +- **VDB**: dendrites deliver current -- **??**: ... +- **VSOMA**: are a proxy for the Coulombs of charge building up on the somatic membrane. + +- **AP**: + +- **bAP**: + +- **SpikeTrainTraces**: sono le tracce che consentono al neurone di far partire il Tuning neuronale, quando e' lontano da uno spike-train, ovvero e' in riposo. --- @@ -126,36 +118,74 @@ container: BEH-SOMA - SpikeTrainTraces ( contained_by: TUN-N ) ``` -## : Context +### ms: behaviors SOMA -Qui mettiamo lo spike Dendritico. Sempre se vogliamo comprenderlo. +#### CheckVDB: Context + +As dendrites deliver current (VDB​), the soma acts like a capacitor. It "stores" this charge in the form of membrane potential. VSOMA is proxy for the Coulombs of charge building up on the somatic membrane. + +Contestualizziamo in maniera Fixed? ```Gen -context: ???... - contained_by: BEH-SOMA - - in_context: Fixed - rf: 60x - - condition: - activate: xxx -``` - -## : Episode - -```Gen -episode: ?? +context: CheckVDB contained_by: BEH-SOMA - in_context: xxx - rf: ( active: 1x ) + in_context: Fixed + rf: ( active: 60x ) - hypothesis: - action: - trace: None + condition: (VDB fullness) + out_context: VDBMax + + condition: (VDB mediumness) + out_context: VDBMedium + + condition: (VDB emptiness) + out_context: VDBLow ``` -## BEH-SOMA-VCGG: Container +##### VDBMax: Episode + +```Gen +episode: VDBMax + contained_by: BEH-SOMA + + in_context: VDBMax + rf: ( active: 2x ) + + hypothesis: NOT (VSOMA full) + action: [VSOMA increase] + trace: +``` + +##### VDBMed: Episode + +```Gen +episode: VDBMed + contained_by: BEH-SOMA + + in_context: VDBMedium + rf: ( active: 4x ) + + hypothesis: NOT (VSOMA full) + action: [VSOMA increase] + trace: +``` + +##### VDBLow: Episode + +```Gen +episode: VDBLow + contained_by: BEH-SOMA + + in_context: VDBLow + rf: ( active: 8x ) + + hypothesis: NOT (VSOMA full) + action: [VSOMA increase] + trace: +``` + +## BEH-SOMA-VGSC: Container Voltage Gated Sodium Channel @@ -164,7 +194,9 @@ container: BEH-SOMA-VGSC ``` -### Episode1 +### ms: behaviors SOMA-VGSC + +#### Episode1 ```Gen episode: ??