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2026-05-25 15:01:32 +02:00
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elements/neuron/presynapse.md
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@@ -6,8 +6,8 @@ include_toc: true
Qui comprendiamo:
- PRESYNAPSE: Presynapse
- VGCC-PRE: Voltage-Controlled Gated Channels
- {PRESYNAPSE}: Presynapse
- {VGCC_PRE}: Voltage-Controlled Gated Channels
## {PRESYNAPSE}
@@ -26,15 +26,6 @@ Qui comprendiamo:
### BEHAVIOR_PRE
**Tubs:**
- **_Ca2+**: Calcium Ion entering the Presynapse when VCGG open that influence NT release. Normally returns to ~0 between spikes; stays elevated when pumps fail. They are key to check the concentration, release NT and modulation
- **_Rrp**: Readily Releasable Pool: The Readily Releasable Pool consists of the vesicles that are "docked" and "primed" at the active zone of the synapse. This pool is very small (usually only about 0.5% to 5% of total vesicles) and can be exhausted quickly during high-frequency firing, leading to "short-term depression" of the signal. Here we consider them as NT ready to be released.
- **_Rp**: Reserve Pool: The bulk of the vesicles held further back in the terminal, often tethered by a protein called synapsin. These are only mobilized during intense, prolonged stimulation. This makes up the vast majority of the vesicles (up to 80% or 90%). Here we consider them NT in reserve that can be transfered to RRP and created using Glutamine from Astorcyte.
- **_NT**: Neuro Transmitter, released in the synapse by the vescicles. The release increses NT and decreases RRP
- **_CaTraces**: sono le tracce di permanenza della concentrazione di Ca2+. Servono alla modulazione (TUN)
- **_eCB**: retrograde signal updates from postsynapsis (postsynaptic input)
```Gen
BEHAVIOR_PRE
@@ -76,10 +67,17 @@ BEHAVIOR_PRE
RefillGlutamine: ACCUMULATOR [RF: active: 24x]
Ca2+TracesClearance: ACCUMULATOR [RF: active: 30x]
```
**Tubs:**
- **_Ca2+**: Calcium Ion entering the Presynapse when VCGG open that influence NT release. Normally returns to ~0 between spikes; stays elevated when pumps fail. They are key to check the concentration, release NT and modulation
- **_Rrp**: Readily Releasable Pool: The Readily Releasable Pool consists of the vesicles that are "docked" and "primed" at the active zone of the synapse. This pool is very small (usually only about 0.5% to 5% of total vesicles) and can be exhausted quickly during high-frequency firing, leading to "short-term depression" of the signal. Here we consider them as NT ready to be released.
- **_Rp**: Reserve Pool: The bulk of the vesicles held further back in the terminal, often tethered by a protein called synapsin. These are only mobilized during intense, prolonged stimulation. This makes up the vast majority of the vesicles (up to 80% or 90%). Here we consider them NT in reserve that can be transfered to RRP and created using Glutamine from Astorcyte.
- **_NT**: Neuro Transmitter, released in the synapse by the vescicles. The release increses NT and decreases RRP
- **_CaTraces**: sono le tracce di permanenza della concentrazione di Ca2+. Servono alla modulazione (TUN)
- **_eCB**: retrograde signal updates from postsynapsis (postsynaptic input)
#### &AP
Il rilascio di NT lo facciamo nel contesto di AP. Biologicamente dovrebbe avvenire solo in base alle concentrazioni, quindi anche al difuori degli AP.
@@ -315,7 +313,7 @@ Ca2+TracesClearance
```Gen
TUNE_VGCC_PRE
# qui stiamo aggiungendo o eliminando VGCC-PRE. Fra un massimo full e minimo empty (empty puo' non essere 0)
# qui stiamo aggiungendo o eliminando {VGCC_PRE}. Fra un massimo full e minimo empty (empty puo' non essere 0)
# contained_by: PRESYNAPSE non e' contenuto, si attacca.
activity_scope: !DAY