diff --git a/elements/neuron/presynapse.md b/elements/neuron/presynapse.md index 105de0b..f8cd6e4 100644 --- a/elements/neuron/presynapse.md +++ b/elements/neuron/presynapse.md @@ -6,8 +6,8 @@ include_toc: true Qui comprendiamo: -- PRESYNAPSE: Presynapse -- VGCC-PRE: Voltage-Controlled Gated Channels +- {PRESYNAPSE}: Presynapse +- {VGCC_PRE}: Voltage-Controlled Gated Channels ## {PRESYNAPSE} @@ -26,15 +26,6 @@ Qui comprendiamo: ### BEHAVIOR_PRE -**Tubs:** - -- **_Ca2+**: Calcium Ion entering the Presynapse when VCGG open that influence NT release. Normally returns to ~0 between spikes; stays elevated when pumps fail. They are key to check the concentration, release NT and modulation -- **_Rrp**: Readily Releasable Pool: The Readily Releasable Pool consists of the vesicles that are "docked" and "primed" at the active zone of the synapse. This pool is very small (usually only about 0.5% to 5% of total vesicles) and can be exhausted quickly during high-frequency firing, leading to "short-term depression" of the signal. Here we consider them as NT ready to be released. -- **_Rp**: Reserve Pool: The bulk of the vesicles held further back in the terminal, often tethered by a protein called synapsin. These are only mobilized during intense, prolonged stimulation. This makes up the vast majority of the vesicles (up to 80% or 90%). Here we consider them NT in reserve that can be transfered to RRP and created using Glutamine from Astorcyte. -- **_NT**: Neuro Transmitter, released in the synapse by the vescicles. The release increses NT and decreases RRP -- **_CaTraces**: sono le tracce di permanenza della concentrazione di Ca2+. Servono alla modulazione (TUN) -- **_eCB**: retrograde signal updates from postsynapsis (postsynaptic input) - ```Gen BEHAVIOR_PRE @@ -76,10 +67,17 @@ BEHAVIOR_PRE RefillGlutamine: ACCUMULATOR [RF: active: 24x] Ca2+TracesClearance: ACCUMULATOR [RF: active: 30x] - - ``` +**Tubs:** + +- **_Ca2+**: Calcium Ion entering the Presynapse when VCGG open that influence NT release. Normally returns to ~0 between spikes; stays elevated when pumps fail. They are key to check the concentration, release NT and modulation +- **_Rrp**: Readily Releasable Pool: The Readily Releasable Pool consists of the vesicles that are "docked" and "primed" at the active zone of the synapse. This pool is very small (usually only about 0.5% to 5% of total vesicles) and can be exhausted quickly during high-frequency firing, leading to "short-term depression" of the signal. Here we consider them as NT ready to be released. +- **_Rp**: Reserve Pool: The bulk of the vesicles held further back in the terminal, often tethered by a protein called synapsin. These are only mobilized during intense, prolonged stimulation. This makes up the vast majority of the vesicles (up to 80% or 90%). Here we consider them NT in reserve that can be transfered to RRP and created using Glutamine from Astorcyte. +- **_NT**: Neuro Transmitter, released in the synapse by the vescicles. The release increses NT and decreases RRP +- **_CaTraces**: sono le tracce di permanenza della concentrazione di Ca2+. Servono alla modulazione (TUN) +- **_eCB**: retrograde signal updates from postsynapsis (postsynaptic input) + #### &AP Il rilascio di NT lo facciamo nel contesto di AP. Biologicamente dovrebbe avvenire solo in base alle concentrazioni, quindi anche al difuori degli AP. @@ -315,7 +313,7 @@ Ca2+TracesClearance ```Gen TUNE_VGCC_PRE - # qui stiamo aggiungendo o eliminando VGCC-PRE. Fra un massimo full e minimo empty (empty puo' non essere 0) + # qui stiamo aggiungendo o eliminando {VGCC_PRE}. Fra un massimo full e minimo empty (empty puo' non essere 0) # contained_by: PRESYNAPSE non e' contenuto, si attacca. activity_scope: !DAY