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2026-05-25 15:01:32 +02:00
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elements/neuron/presynapse.md
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@@ -6,8 +6,8 @@ include_toc: true
Qui comprendiamo: Qui comprendiamo:
- PRESYNAPSE: Presynapse - {PRESYNAPSE}: Presynapse
- VGCC-PRE: Voltage-Controlled Gated Channels - {VGCC_PRE}: Voltage-Controlled Gated Channels
## {PRESYNAPSE} ## {PRESYNAPSE}
@@ -26,15 +26,6 @@ Qui comprendiamo:
### BEHAVIOR_PRE ### BEHAVIOR_PRE
**Tubs:**
- **_Ca2+**: Calcium Ion entering the Presynapse when VCGG open that influence NT release. Normally returns to ~0 between spikes; stays elevated when pumps fail. They are key to check the concentration, release NT and modulation
- **_Rrp**: Readily Releasable Pool: The Readily Releasable Pool consists of the vesicles that are "docked" and "primed" at the active zone of the synapse. This pool is very small (usually only about 0.5% to 5% of total vesicles) and can be exhausted quickly during high-frequency firing, leading to "short-term depression" of the signal. Here we consider them as NT ready to be released.
- **_Rp**: Reserve Pool: The bulk of the vesicles held further back in the terminal, often tethered by a protein called synapsin. These are only mobilized during intense, prolonged stimulation. This makes up the vast majority of the vesicles (up to 80% or 90%). Here we consider them NT in reserve that can be transfered to RRP and created using Glutamine from Astorcyte.
- **_NT**: Neuro Transmitter, released in the synapse by the vescicles. The release increses NT and decreases RRP
- **_CaTraces**: sono le tracce di permanenza della concentrazione di Ca2+. Servono alla modulazione (TUN)
- **_eCB**: retrograde signal updates from postsynapsis (postsynaptic input)
```Gen ```Gen
BEHAVIOR_PRE BEHAVIOR_PRE
@@ -76,10 +67,17 @@ BEHAVIOR_PRE
RefillGlutamine: ACCUMULATOR [RF: active: 24x] RefillGlutamine: ACCUMULATOR [RF: active: 24x]
Ca2+TracesClearance: ACCUMULATOR [RF: active: 30x] Ca2+TracesClearance: ACCUMULATOR [RF: active: 30x]
``` ```
**Tubs:**
- **_Ca2+**: Calcium Ion entering the Presynapse when VCGG open that influence NT release. Normally returns to ~0 between spikes; stays elevated when pumps fail. They are key to check the concentration, release NT and modulation
- **_Rrp**: Readily Releasable Pool: The Readily Releasable Pool consists of the vesicles that are "docked" and "primed" at the active zone of the synapse. This pool is very small (usually only about 0.5% to 5% of total vesicles) and can be exhausted quickly during high-frequency firing, leading to "short-term depression" of the signal. Here we consider them as NT ready to be released.
- **_Rp**: Reserve Pool: The bulk of the vesicles held further back in the terminal, often tethered by a protein called synapsin. These are only mobilized during intense, prolonged stimulation. This makes up the vast majority of the vesicles (up to 80% or 90%). Here we consider them NT in reserve that can be transfered to RRP and created using Glutamine from Astorcyte.
- **_NT**: Neuro Transmitter, released in the synapse by the vescicles. The release increses NT and decreases RRP
- **_CaTraces**: sono le tracce di permanenza della concentrazione di Ca2+. Servono alla modulazione (TUN)
- **_eCB**: retrograde signal updates from postsynapsis (postsynaptic input)
#### &AP #### &AP
Il rilascio di NT lo facciamo nel contesto di AP. Biologicamente dovrebbe avvenire solo in base alle concentrazioni, quindi anche al difuori degli AP. Il rilascio di NT lo facciamo nel contesto di AP. Biologicamente dovrebbe avvenire solo in base alle concentrazioni, quindi anche al difuori degli AP.
@@ -315,7 +313,7 @@ Ca2+TracesClearance
```Gen ```Gen
TUNE_VGCC_PRE TUNE_VGCC_PRE
# qui stiamo aggiungendo o eliminando VGCC-PRE. Fra un massimo full e minimo empty (empty puo' non essere 0) # qui stiamo aggiungendo o eliminando {VGCC_PRE}. Fra un massimo full e minimo empty (empty puo' non essere 0)
# contained_by: PRESYNAPSE non e' contenuto, si attacca. # contained_by: PRESYNAPSE non e' contenuto, si attacca.
activity_scope: !DAY activity_scope: !DAY