Update presynapse.md
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@@ -47,7 +47,7 @@ PRESYNAPSE
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// Context
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*AP: INTRICATE [ context: &SOMA.*AP ]
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*TunPossible: INTRICATE [ context: &NEURON.*TunPossible ]
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*Spike_train: INTRICATE [ context: &NEURON.*Spike_train ]
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// Tub
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_NT: INTRICATE [ tub: &ASTROSYNAPSE._NT ]
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@@ -83,7 +83,7 @@ PRESYNAPSE
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```
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## ACTION
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## ACTION | !DAY | *AP
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```Gen
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@@ -91,8 +91,6 @@ ACTION
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type: container
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// !DAY | *AP
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// ########################## NTRelease | Fast (ms–s) ##########################
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// Devo aggiungere la limitazione dovuta al Glutamate Spillover GluR e retro_eCB !!!!
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@@ -131,17 +129,15 @@ ACTION
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```
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## TRACE
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## RECOVER | !DAY | ( NOT *AP ) AND ( NOT *Spike_train )
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```Gen
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TRACE
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RECOVER
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type: container
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// !DAY | NOT *AP
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// ########################## _Ca2 level | Short (ms–s) ##########################
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// ########################## _Ca2 level | Fast (ms–s) ##########################
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TracesAccLow: INSTANTIATE [ snippet: accumulator, event: 3x ] {
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hypothesis: _Ca2 emptiness
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@@ -164,22 +160,7 @@ TRACE
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else: None
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}
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// ########################## Long (hr) ##########################
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```
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## DECAY
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```Gen
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DECAY
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type: container
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// !DAY | NOT *AP
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// ########################## TracesClearance | Short (ms–s) ##########################
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// ########################## TracesClearance | Fast (ms–s) ##########################
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TracesClearance: INSTANTIATE [ snippet: accumulator, event: 30x] {
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@@ -199,39 +180,8 @@ DECAY
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else: None
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}
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// ########################## eCBClearance | Medium (s–min) ##########################
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eCBClearenceMedium: INSTANTIATE [ snippet: accumulator, event: 24x ] {
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hypothesis: NOT _eCB empty
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action: [ _eCB decrease ]
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cost:
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else: None
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}
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eCBClearenceLow: INSTANTIATE [ snippet: accumulator, event: 48x] {
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hypothesis: NOT _eCB empty
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action: [ _eCB decrease ]
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cost:
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else: None
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}
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// ########################## ??? | Long (hr) ##########################
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```
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## RECOVER
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```Gen
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RECOVER
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type: container
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// !DAY | NOT *AP
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// ########################## Rp Shuttle | Short (ms–s) ##########################
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// ########################## Rp Shuttle | Fast (ms–s) ##########################
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// The "Hard Bottleneck" State. Recruitment is throttled by a lack of signal, a lack of supply, or a lack of space.
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// If even one of these "Near-Stop" conditions is met, the rate cannot exceed "Slow," regardless of the other two conditions.
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@@ -258,24 +208,9 @@ RECOVER
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else: None
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}
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// ########################## RefillGlutamine | Medium (s–min) ##########################
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// The "High Performance" State. Multiple systems are optimized, but one is still at a "mediumness" level.
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// This represents an active synapse that hasn't reached its absolute peak because either the supply is only 50%
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// or the \_Rrp isn't empty enough to create that "maximal vacuum" pull. Rate: 1.25 – 1.94
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RefillGlutamine: INSTANTIATE [ snippet: accumulator, event: 24x ] {
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hypothesis: ( _CaTraceHigh fullness AND _RP fullness AND _Rrp mediumness ) OR # signal + supply
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( _CaTraceHigh fullness AND _RP mediumness AND _Rrp emptiness ) OR # signal + vacancy
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( _CaTraceMedium fullness AND _RP fullness AND _Rrp emptiness ) # supply + vacancy
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action: [ _RP decrease, _Rrp increase ]
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cost:
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else: None
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}
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```
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## ADJUST
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## ADJUST | !DAY | NOT *Spike_train
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```Gen
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@@ -283,8 +218,6 @@ ADJUST
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type: container
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// !DAY | *TunPossible
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// ########################## PRE_VGCC Tun | Medium (s–min) ##########################
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// qui stiamo attivando e disattivando PRE_VGCC. Fra un massimo full e minimo empty (empty puo' non essere 0)
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@@ -303,6 +236,37 @@ ADJUST
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cost: [ _pre_budget increase 3x ]
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else:
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}
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// ########################## RefillGlutamine | Medium (s–min) ##########################
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// The "High Performance" State. Multiple systems are optimized, but one is still at a "mediumness" level.
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// This represents an active synapse that hasn't reached its absolute peak because either the supply is only 50%
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// or the \_Rrp isn't empty enough to create that "maximal vacuum" pull. Rate: 1.25 – 1.94
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RefillGlutamine: INSTANTIATE [ snippet: accumulator, event: 24x ] {
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hypothesis: ( _CaTraceHigh fullness AND _RP fullness AND _Rrp mediumness ) OR # signal + supply
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( _CaTraceHigh fullness AND _RP mediumness AND _Rrp emptiness ) OR # signal + vacancy
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( _CaTraceMedium fullness AND _RP fullness AND _Rrp emptiness ) # supply + vacancy
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action: [ _RP decrease, _Rrp increase ]
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cost:
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else: None
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}
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// ########################## eCBClearance | Medium (s–min) ##########################
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eCBClearenceMedium: INSTANTIATE [ snippet: accumulator, event: 24x ] {
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hypothesis: NOT _eCB empty
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action: [ _eCB decrease ]
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cost:
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else: None
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}
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eCBClearenceLow: INSTANTIATE [ snippet: accumulator, event: 48x] {
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hypothesis: NOT _eCB empty
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action: [ _eCB decrease ]
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cost:
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else: None
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}
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```
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