From 8b33560dffdb6445551bf5140e8878e554030522 Mon Sep 17 00:00:00 2001 From: ocrampal Date: Sat, 4 Jul 2026 15:37:53 +0200 Subject: [PATCH] Update presynapse.md --- elements/neuron/presynapse.md | 114 ++++++++++++---------------------- 1 file changed, 39 insertions(+), 75 deletions(-) diff --git a/elements/neuron/presynapse.md b/elements/neuron/presynapse.md index 932a3d8..9789d81 100644 --- a/elements/neuron/presynapse.md +++ b/elements/neuron/presynapse.md @@ -47,7 +47,7 @@ PRESYNAPSE // Context *AP: INTRICATE [ context: &SOMA.*AP ] - *TunPossible: INTRICATE [ context: &NEURON.*TunPossible ] + *Spike_train: INTRICATE [ context: &NEURON.*Spike_train ] // Tub _NT: INTRICATE [ tub: &ASTROSYNAPSE._NT ] @@ -83,7 +83,7 @@ PRESYNAPSE ``` -## ACTION +## ACTION | !DAY | *AP ```Gen @@ -91,8 +91,6 @@ ACTION type: container - // !DAY | *AP - // ########################## NTRelease | Fast (ms–s) ########################## // Devo aggiungere la limitazione dovuta al Glutamate Spillover GluR e retro_eCB !!!! @@ -131,17 +129,15 @@ ACTION ``` -## TRACE +## RECOVER | !DAY | ( NOT *AP ) AND ( NOT *Spike_train ) ```Gen -TRACE +RECOVER type: container - // !DAY | NOT *AP - - // ########################## _Ca2 level | Short (ms–s) ########################## + // ########################## _Ca2 level | Fast (ms–s) ########################## TracesAccLow: INSTANTIATE [ snippet: accumulator, event: 3x ] { hypothesis: _Ca2 emptiness @@ -164,22 +160,7 @@ TRACE else: None } - // ########################## Long (hr) ########################## - - -``` - -## DECAY - -```Gen - -DECAY - - type: container - - // !DAY | NOT *AP - - // ########################## TracesClearance | Short (ms–s) ########################## + // ########################## TracesClearance | Fast (ms–s) ########################## TracesClearance: INSTANTIATE [ snippet: accumulator, event: 30x] { @@ -199,39 +180,8 @@ DECAY else: None } - - // ########################## eCBClearance | Medium (s–min) ########################## - - eCBClearenceMedium: INSTANTIATE [ snippet: accumulator, event: 24x ] { - hypothesis: NOT _eCB empty - action: [ _eCB decrease ] - cost: - else: None - } - eCBClearenceLow: INSTANTIATE [ snippet: accumulator, event: 48x] { - hypothesis: NOT _eCB empty - action: [ _eCB decrease ] - cost: - else: None - } - - // ########################## ??? | Long (hr) ########################## - - -``` - -## RECOVER - -```Gen - -RECOVER - - type: container - - // !DAY | NOT *AP - - // ########################## Rp Shuttle | Short (ms–s) ########################## + // ########################## Rp Shuttle | Fast (ms–s) ########################## // The "Hard Bottleneck" State. Recruitment is throttled by a lack of signal, a lack of supply, or a lack of space. // If even one of these "Near-Stop" conditions is met, the rate cannot exceed "Slow," regardless of the other two conditions. @@ -258,24 +208,9 @@ RECOVER else: None } - // ########################## RefillGlutamine | Medium (s–min) ########################## - - // The "High Performance" State. Multiple systems are optimized, but one is still at a "mediumness" level. - // This represents an active synapse that hasn't reached its absolute peak because either the supply is only 50% - // or the \_Rrp isn't empty enough to create that "maximal vacuum" pull. Rate: 1.25 – 1.94 - - RefillGlutamine: INSTANTIATE [ snippet: accumulator, event: 24x ] { - hypothesis: ( _CaTraceHigh fullness AND _RP fullness AND _Rrp mediumness ) OR # signal + supply - ( _CaTraceHigh fullness AND _RP mediumness AND _Rrp emptiness ) OR # signal + vacancy - ( _CaTraceMedium fullness AND _RP fullness AND _Rrp emptiness ) # supply + vacancy - action: [ _RP decrease, _Rrp increase ] - cost: - else: None - } - ``` -## ADJUST +## ADJUST | !DAY | NOT *Spike_train ```Gen @@ -283,8 +218,6 @@ ADJUST type: container - // !DAY | *TunPossible - // ########################## PRE_VGCC Tun | Medium (s–min) ########################## // qui stiamo attivando e disattivando PRE_VGCC. Fra un massimo full e minimo empty (empty puo' non essere 0) @@ -303,6 +236,37 @@ ADJUST cost: [ _pre_budget increase 3x ] else: } + + // ########################## RefillGlutamine | Medium (s–min) ########################## + + // The "High Performance" State. Multiple systems are optimized, but one is still at a "mediumness" level. + // This represents an active synapse that hasn't reached its absolute peak because either the supply is only 50% + // or the \_Rrp isn't empty enough to create that "maximal vacuum" pull. Rate: 1.25 – 1.94 + + RefillGlutamine: INSTANTIATE [ snippet: accumulator, event: 24x ] { + hypothesis: ( _CaTraceHigh fullness AND _RP fullness AND _Rrp mediumness ) OR # signal + supply + ( _CaTraceHigh fullness AND _RP mediumness AND _Rrp emptiness ) OR # signal + vacancy + ( _CaTraceMedium fullness AND _RP fullness AND _Rrp emptiness ) # supply + vacancy + action: [ _RP decrease, _Rrp increase ] + cost: + else: None + } + + // ########################## eCBClearance | Medium (s–min) ########################## + + eCBClearenceMedium: INSTANTIATE [ snippet: accumulator, event: 24x ] { + hypothesis: NOT _eCB empty + action: [ _eCB decrease ] + cost: + else: None + } + + eCBClearenceLow: INSTANTIATE [ snippet: accumulator, event: 48x] { + hypothesis: NOT _eCB empty + action: [ _eCB decrease ] + cost: + else: None + } ```