Update presynapse.md
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# presynapse.md
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Modulation:
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- is developed by: [AXON](axon.md)
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- is tuned by: ORGANISM, organs, modules
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- tunes: [VGCC_PRE](#vgcc_pre)
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Qui comprendiamo:
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- [PRESYNAPSE](#presynapse)
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- [VCGG](#vgcc_pre) Voltage-Controlled Gated Channels
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- qui comprendiamo:
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- [PRESYNAPSE](#presynapse)
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- [VCGG](#vgcc_pre) Voltage-Controlled Gated Channels
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## PRESYNAPSE
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- Modulation:
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- is developed by: [AXON](axon.md)
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- is tuned by: ORGANISM, organs, modules
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- tunes: [VGCC_PRE](#vgcc_pre)
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```Gen
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PRESYNAPSE
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type: comprehension
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@@ -97,12 +95,12 @@ MAIN_PRE
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**Tubs:**
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- **_Ca2**: Calcium Ion entering the Presynapse when VCGG open that influence NT release. Normally returns to ~0 between spikes; stays elevated when pumps fail. They are key to check the concentration, release NT and modulation
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- **_Rrp**: Readily Releasable Pool: The Readily Releasable Pool consists of the vesicles that are "docked" and "primed" at the active zone of the synapse. This pool is very small (usually only about 0.5% to 5% of total vesicles) and can be exhausted quickly during high-frequency firing, leading to "short-term depression" of the signal. Here we consider them as NT ready to be released.
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- **_Rp**: Reserve Pool: The bulk of the vesicles held further back in the terminal, often tethered by a protein called synapsin. These are only mobilized during intense, prolonged stimulation. This makes up the vast majority of the vesicles (up to 80% or 90%). Here we consider them NT in reserve that can be transfered to RRP and created using Glutamine from Astorcyte.
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- **_NT**: Neuro Transmitter, released in the synapse by the vescicles. The release increses NT and decreases RRP
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- **_CaTracesXXX**: sono le tracce di permanenza della concentrazione di Ca2. Servono alla modulazione (TUN)
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- **_eCB**: retrograde signal updates from postsynapsis (postsynaptic input)
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- **\_Ca2**: Calcium Ion entering the Presynapse when VCGG open that influence NT release. Normally returns to ~0 between spikes; stays elevated when pumps fail. They are key to check the concentration, release NT and modulation
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- **\_Rrp**: Readily Releasable Pool: The Readily Releasable Pool consists of the vesicles that are "docked" and "primed" at the active zone of the synapse. This pool is very small (usually only about 0.5% to 5% of total vesicles) and can be exhausted quickly during high-frequency firing, leading to "short-term depression" of the signal. Here we consider them as NT ready to be released.
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- **\_Rp**: Reserve Pool: The bulk of the vesicles held further back in the terminal, often tethered by a protein called synapsin. These are only mobilized during intense, prolonged stimulation. This makes up the vast majority of the vesicles (up to 80% or 90%). Here we consider them NT in reserve that can be transfered to RRP and created using Glutamine from Astorcyte.
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- **\_NT**: Neuro Transmitter, released in the synapse by the vescicles. The release increses NT and decreases RRP
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- **\_CaTracesXXX**: sono le tracce di permanenza della concentrazione di Ca2. Servono alla modulazione (TUN)
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- **\_eCB**: retrograde signal updates from postsynapsis (postsynaptic input)
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#### *AP
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@@ -169,7 +167,7 @@ NTreleaseHigh
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Serve a:
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- fare il tuning dei VGCC
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- dare la velocita' al trasporto di vesicles da RP a RRP, anche se non avendo ancora compreso _ATP, la velocita' non cambia molto la sostanza.
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- dare la velocita' al trasporto di vesicles da RP a RRP, anche se non avendo ancora compreso \_ATP, la velocita' non cambia molto la sostanza.
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- le tracce vengono eliminate quando il neurone e' in pausa, lontano da uno spike train, *TunePossible
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- Abbiamo 3 tracce, high, medium and low. Andiamo a verificare una combinazione di queste per fare la modulazione
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- RF e' a 10, questo dovrebbe essere un RF di campionamento durante *AP context che dovremmo assicurarci sia tipo 100. Il che implicherebbe 10 campionamenti.
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@@ -275,7 +273,7 @@ RPShuttleMedium
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##### RPShuttleHigh
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The "High Performance" State. Multiple systems are optimized, but one is still at a "mediumness" level. This represents an active synapse that hasn't reached its absolute peak because either the supply is only 50% or the _Rrp isn't empty enough to create that "maximal vacuum" pull.
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The "High Performance" State. Multiple systems are optimized, but one is still at a "mediumness" level. This represents an active synapse that hasn't reached its absolute peak because either the supply is only 50% or the \_Rrp isn't empty enough to create that "maximal vacuum" pull.
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Rate: 1.25 – 1.94
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@@ -420,8 +418,8 @@ PossibleDownPreVgccTun
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## VGCC_PRE
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Modulation:
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- is tuned by: [PRESYNAPSE](#presynapse)
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- is tuned by: [PRESYNAPSE](#presynapse)
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Voltage-Controlled Gated Channels: Qui per ora non gestiamo l'evoluzione della depolarizzazione. Alla scomparsa dell'AP, i VGCC smettono di funzionare.
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@@ -467,7 +465,6 @@ VGCC_PRE_BEH
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# NOT *AP
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@: ACCUMULATOR [ snippet: Ca2ClearanceLow, rf: active 24x ]
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@: ACCUMULATOR [ snippet: Ca2ClearanceHigh, rf: active 4x ]
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```
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#### *AP
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@@ -481,10 +478,9 @@ Here we comprehend the breaking activity on VGCC by: CDI, eCB and mGluR:
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Qui semplifichiamo:
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- Approssimiamo CDI con concentrazione di Ca2.
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-- CDI is calcium-dependent inactivation of VGCCs. The inactivation happens because Ca2 enters through the channel and binds to a calmodulin tethered to the channel's intracellular face, physically blocking it from reopening. This is a local, channel-specific event — it requires Ca2 to be flowing through that channel right now, not residual Ca2 drifting in the cytosol between spikes.
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-- The recovery, by contrast, should run every millisecond unconditionally — CDI de-inactivation is a continuous process that proceeds whenever Ca2 dissociates from calmodulin, which depends on the ambient Ca_micro level at all times.
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\-- CDI is calcium-dependent inactivation of VGCCs. The inactivation happens because Ca2 enters through the channel and binds to a calmodulin tethered to the channel's intracellular face, physically blocking it from reopening. This is a local, channel-specific event — it requires Ca2 to be flowing through that channel right now, not residual Ca2 drifting in the cytosol between spikes.
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\-- The recovery, by contrast, should run every millisecond unconditionally — CDI de-inactivation is a continuous process that proceeds whenever Ca2 dissociates from calmodulin, which depends on the ambient Ca_micro level at all times.
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- Approssimiamo mGluR con concentrazione NT
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- **Open** — zero active brakes. mGluR alone never escapes this group because its ceiling is alpha_mGluR = 0.4, meaning even at full it only removes 40% of conductance, leaving 60% — still above the 85% threshold. So mGluR is irrelevant to the open/not-open boundary. Only CDI and eCB decide.
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- **Reduced/partial** — exactly one meaningful brake active. Either CDI has started building (mediumness), or eCB has risen from sustained postsynaptic activity, but not both simultaneously. The system is aware something is happening but has not compounded yet. This is the normal operating range during moderate sustained firing.
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- **Suppressed** — two brakes multiplying. The compounding is what defines this zone — no single variable alone produces it (except CDI approaching full). 0.5 × 0.5 = 0.25 remaining is where the synapse starts losing significant transmission efficacy. Biologically this is the pre-silence warning zone: CDI is building from residual Ca2 while eCB is already engaged from postsynaptic activity.
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@@ -536,7 +532,7 @@ Ca2enterHigh
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#### NOT *AP
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Qui eliminiamo Ca2. Il tempo che ci mette ad eliminare il Ca2 dovrebbe essere minoe dell'inervallo fra un *AP e un'altra. Siccome non comprendiamo per ora _ATP, non c'e' accumulo di Ca2 per mancanza di _ATP (stanchezza).
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Qui eliminiamo Ca2. Il tempo che ci mette ad eliminare il Ca2 dovrebbe essere minoe dell'inervallo fra un *AP e un'altra. Siccome non comprendiamo per ora \_ATP, non c'e' accumulo di Ca2 per mancanza di \_ATP (stanchezza).
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Non non comprendiamo anche il ristabilimento del Voltage, con altri Ioni entranti e uscenti, per ora tutto dipende da AP del SOMA. Non comprendiamo per ora:
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