varie
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@@ -447,6 +447,32 @@ In this comprehension we decide to simplify:
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- We do not model Desensitization_level — receptor availability is assumed constant
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- We do not model Desensitization_level — receptor availability is assumed constant
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- We do not model Ca²⁺ clearance detail — Ca_post decays with a single slow term
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- We do not model Ca²⁺ clearance detail — Ca_post decays with a single slow term
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— ms:
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- NT arrives in cleft → AMPA receptors bind NT (receptor availability constant, no desensitization)
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- V_post rises with AMPA conductance, decays passively each ms
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- bAP arrives → V_post receives additional depolarisation boost
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- NMDA gate checks coincidence: NT_cleft AND V_post both non-zero
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- Mg_block_removal = V_post / (V_post + V_NMDA_half) — sigmoid of V_post
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- _Ca2 enters spine via NMDA: Ca_post += k_NMDA × NT_cleft × Mg_block_removal
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- Ca_post decays slowly each ms (single exponential, no pump detail)
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- Ca_post_history updated every ms (feeds seconds loop)
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- V_post_history updated every ms (retained for reference)
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— seconds:
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- Ca_post_history mean computed over past 2 s
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- eCB synthesised when Ca_post_history mean exceeds eCB threshold
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- eCB_level decays when Ca_post_history mean falls below threshold
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- eCB_level written → read by presynapse as retrograde brake on VGCCs
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- Ca_post_history compared to LTP/LTD thresholds → plasticity tag set
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— mins:
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- If Plasticity_LTP tagged → AMPA density increases
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- If Plasticity_LTD tagged → AMPA density decreases
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- AMPA density feeds back into receptor_conductance ceiling for next cycle
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The simplification implies that:
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The simplification implies that:
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- Removing ATP removes the false eCB trigger mechanism entirely. The retrograde signal remains but it is always genuine — driven by real Ca_post elevation from NMDA coincidence, not pump failure. The synapse cannot enter the excitotoxic protection cascade.
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- Removing ATP removes the false eCB trigger mechanism entirely. The retrograde signal remains but it is always genuine — driven by real Ca_post elevation from NMDA coincidence, not pump failure. The synapse cannot enter the excitotoxic protection cascade.
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@@ -4,65 +4,23 @@ include_toc: true
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# postsynapse.md
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# postsynapse.md
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Qui comprendiamo:
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Expansions and modulations:
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- POSTSYNAPSE: Postsynapse
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- POST-AMPA: AMPA receptors (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors)
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**Simplified Behaviors**:
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— ms:
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- NT arrives in cleft → AMPA receptors bind NT (receptor availability constant, no desensitization)
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- V_post rises with AMPA conductance, decays passively each ms
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- bAP arrives → V_post receives additional depolarisation boost
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- NMDA gate checks coincidence: NT_cleft AND V_post both non-zero
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- Mg_block_removal = V_post / (V_post + V_NMDA_half) — sigmoid of V_post
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- _Ca2 enters spine via NMDA: Ca_post += k_NMDA × NT_cleft × Mg_block_removal
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- Ca_post decays slowly each ms (single exponential, no pump detail)
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- Ca_post_history updated every ms (feeds seconds loop)
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- V_post_history updated every ms (retained for reference)
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— seconds:
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- Ca_post_history mean computed over past 2 s
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- eCB synthesised when Ca_post_history mean exceeds eCB threshold
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- eCB_level decays when Ca_post_history mean falls below threshold
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- eCB_level written → read by presynapse as retrograde brake on VGCCs
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- Ca_post_history compared to LTP/LTD thresholds → plasticity tag set
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— mins:
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- If Plasticity_LTP tagged → AMPA density increases
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- If Plasticity_LTD tagged → AMPA density decreases
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- AMPA density feeds back into receptor_conductance ceiling for next cycle
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---
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**Tubs:**
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- **_Na**: Ioni entranti tramite AMPA receptors
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- **_NT**: Neuro Trasmettitori
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- **_Ca2**: Ioni entranti tramite NMDA
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- **_VPost**: il voltage che viene sentito in DB
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- **_eCB**:
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- **_Nox**:?
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---
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Intro:
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- is expanded and developed by: [D_BRANCH](d-branch.md)
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- is expanded and developed by: [D_BRANCH](d-branch.md)
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- is tuned by: ORGANISM, organs, modules
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- is tuned by: ORGANISM, organs, modules
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- expands and tunes: [POST-AMPA](post_ampa.md)
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- expands and tunes: [POST-AMPA](post_ampa.md)
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- develops [_posMod](??), [_actMod](??)
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- develops [_posMod](??), [_actMod](??)
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## POSTSYNAPSE
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## POSTSYNAPSE
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```Gen
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```Gen
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POSTSYNAPSE
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type: comprehension
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include: post_ampa.md
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include:
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post_ampa.md
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POSTSYNAPSE
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type: comprehension
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expansion:
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expansion:
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_@PostAmpaAll: TUB [ comprehension: POST-AMPA, full: 10x, active: 5x, empty: 2x ]
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_@PostAmpaAll: TUB [ comprehension: POST-AMPA, full: 10x, active: 5x, empty: 2x ]
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@@ -98,6 +56,15 @@ POSTSYNAPSE
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```
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```
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**Tubs:**
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- **_Na**: Ioni entranti tramite AMPA receptors
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- **_NT**: Neuro Trasmettitori
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- **_Ca2**: Ioni entranti tramite NMDA
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- **_VPost**: il voltage che viene sentito in DB
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- **_eCB**:
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- **_Nox**:?
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### MAIN_POST: !DAY
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### MAIN_POST: !DAY
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```
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```
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MAIN_POST
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MAIN_POST
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