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2026-06-01 11:16:49 +02:00
parent 04730466bb
commit 7df73fb177
2 changed files with 43 additions and 50 deletions
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@@ -447,6 +447,32 @@ In this comprehension we decide to simplify:
- We do not model Desensitization_level — receptor availability is assumed constant - We do not model Desensitization_level — receptor availability is assumed constant
- We do not model Ca²⁺ clearance detail — Ca_post decays with a single slow term - We do not model Ca²⁺ clearance detail — Ca_post decays with a single slow term
— ms:
- NT arrives in cleft → AMPA receptors bind NT (receptor availability constant, no desensitization)
- V_post rises with AMPA conductance, decays passively each ms
- bAP arrives → V_post receives additional depolarisation boost
- NMDA gate checks coincidence: NT_cleft AND V_post both non-zero
- Mg_block_removal = V_post / (V_post + V_NMDA_half) — sigmoid of V_post
- _Ca2 enters spine via NMDA: Ca_post += k_NMDA × NT_cleft × Mg_block_removal
- Ca_post decays slowly each ms (single exponential, no pump detail)
- Ca_post_history updated every ms (feeds seconds loop)
- V_post_history updated every ms (retained for reference)
— seconds:
- Ca_post_history mean computed over past 2 s
- eCB synthesised when Ca_post_history mean exceeds eCB threshold
- eCB_level decays when Ca_post_history mean falls below threshold
- eCB_level written → read by presynapse as retrograde brake on VGCCs
- Ca_post_history compared to LTP/LTD thresholds → plasticity tag set
— mins:
- If Plasticity_LTP tagged → AMPA density increases
- If Plasticity_LTD tagged → AMPA density decreases
- AMPA density feeds back into receptor_conductance ceiling for next cycle
The simplification implies that: The simplification implies that:
- Removing ATP removes the false eCB trigger mechanism entirely. The retrograde signal remains but it is always genuine — driven by real Ca_post elevation from NMDA coincidence, not pump failure. The synapse cannot enter the excitotoxic protection cascade. - Removing ATP removes the false eCB trigger mechanism entirely. The retrograde signal remains but it is always genuine — driven by real Ca_post elevation from NMDA coincidence, not pump failure. The synapse cannot enter the excitotoxic protection cascade.
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@@ -4,65 +4,23 @@ include_toc: true
# postsynapse.md # postsynapse.md
Qui comprendiamo: Expansions and modulations:
- POSTSYNAPSE: Postsynapse
- POST-AMPA: AMPA receptors (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors)
**Simplified Behaviors**:
— ms:
- NT arrives in cleft → AMPA receptors bind NT (receptor availability constant, no desensitization)
- V_post rises with AMPA conductance, decays passively each ms
- bAP arrives → V_post receives additional depolarisation boost
- NMDA gate checks coincidence: NT_cleft AND V_post both non-zero
- Mg_block_removal = V_post / (V_post + V_NMDA_half) — sigmoid of V_post
- _Ca2 enters spine via NMDA: Ca_post += k_NMDA × NT_cleft × Mg_block_removal
- Ca_post decays slowly each ms (single exponential, no pump detail)
- Ca_post_history updated every ms (feeds seconds loop)
- V_post_history updated every ms (retained for reference)
— seconds:
- Ca_post_history mean computed over past 2 s
- eCB synthesised when Ca_post_history mean exceeds eCB threshold
- eCB_level decays when Ca_post_history mean falls below threshold
- eCB_level written → read by presynapse as retrograde brake on VGCCs
- Ca_post_history compared to LTP/LTD thresholds → plasticity tag set
— mins:
- If Plasticity_LTP tagged → AMPA density increases
- If Plasticity_LTD tagged → AMPA density decreases
- AMPA density feeds back into receptor_conductance ceiling for next cycle
---
**Tubs:**
- **_Na**: Ioni entranti tramite AMPA receptors
- **_NT**: Neuro Trasmettitori
- **_Ca2**: Ioni entranti tramite NMDA
- **_VPost**: il voltage che viene sentito in DB
- **_eCB**:
- **_Nox**:?
---
Intro:
- is expanded and developed by: [D_BRANCH](d-branch.md) - is expanded and developed by: [D_BRANCH](d-branch.md)
- is tuned by: ORGANISM, organs, modules - is tuned by: ORGANISM, organs, modules
- expands and tunes: [POST-AMPA](post_ampa.md) - expands and tunes: [POST-AMPA](post_ampa.md)
- develops [_posMod](??), [_actMod](??) - develops [_posMod](??), [_actMod](??)
## POSTSYNAPSE ## POSTSYNAPSE
```Gen ```Gen
POSTSYNAPSE
type: comprehension
include: post_ampa.md include:
post_ampa.md
POSTSYNAPSE
type: comprehension
expansion: expansion:
_@PostAmpaAll: TUB [ comprehension: POST-AMPA, full: 10x, active: 5x, empty: 2x ] _@PostAmpaAll: TUB [ comprehension: POST-AMPA, full: 10x, active: 5x, empty: 2x ]
@@ -98,6 +56,15 @@ POSTSYNAPSE
``` ```
**Tubs:**
- **_Na**: Ioni entranti tramite AMPA receptors
- **_NT**: Neuro Trasmettitori
- **_Ca2**: Ioni entranti tramite NMDA
- **_VPost**: il voltage che viene sentito in DB
- **_eCB**:
- **_Nox**:?
### MAIN_POST: !DAY ### MAIN_POST: !DAY
``` ```
MAIN_POST MAIN_POST