diff --git a/elements/neuron/README.md b/elements/neuron/README.md index bc951e0..2187d84 100644 --- a/elements/neuron/README.md +++ b/elements/neuron/README.md @@ -447,6 +447,32 @@ In this comprehension we decide to simplify: - We do not model Desensitization_level — receptor availability is assumed constant - We do not model Ca²⁺ clearance detail — Ca_post decays with a single slow term +— ms: + +- NT arrives in cleft → AMPA receptors bind NT (receptor availability constant, no desensitization) +- V_post rises with AMPA conductance, decays passively each ms +- bAP arrives → V_post receives additional depolarisation boost +- NMDA gate checks coincidence: NT_cleft AND V_post both non-zero +- Mg_block_removal = V_post / (V_post + V_NMDA_half) — sigmoid of V_post +- _Ca2 enters spine via NMDA: Ca_post += k_NMDA × NT_cleft × Mg_block_removal +- Ca_post decays slowly each ms (single exponential, no pump detail) +- Ca_post_history updated every ms (feeds seconds loop) +- V_post_history updated every ms (retained for reference) + +— seconds: + +- Ca_post_history mean computed over past 2 s +- eCB synthesised when Ca_post_history mean exceeds eCB threshold +- eCB_level decays when Ca_post_history mean falls below threshold +- eCB_level written → read by presynapse as retrograde brake on VGCCs +- Ca_post_history compared to LTP/LTD thresholds → plasticity tag set + +— mins: + +- If Plasticity_LTP tagged → AMPA density increases +- If Plasticity_LTD tagged → AMPA density decreases +- AMPA density feeds back into receptor_conductance ceiling for next cycle + The simplification implies that: - Removing ATP removes the false eCB trigger mechanism entirely. The retrograde signal remains but it is always genuine — driven by real Ca_post elevation from NMDA coincidence, not pump failure. The synapse cannot enter the excitotoxic protection cascade. diff --git a/elements/neuron/postsynapse.md b/elements/neuron/postsynapse.md index ec470f5..31aa0b1 100644 --- a/elements/neuron/postsynapse.md +++ b/elements/neuron/postsynapse.md @@ -4,65 +4,23 @@ include_toc: true # postsynapse.md -Qui comprendiamo: - -- POSTSYNAPSE: Postsynapse -- POST-AMPA: AMPA receptors (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors) - -**Simplified Behaviors**: - -— ms: - -- NT arrives in cleft → AMPA receptors bind NT (receptor availability constant, no desensitization) -- V_post rises with AMPA conductance, decays passively each ms -- bAP arrives → V_post receives additional depolarisation boost -- NMDA gate checks coincidence: NT_cleft AND V_post both non-zero -- Mg_block_removal = V_post / (V_post + V_NMDA_half) — sigmoid of V_post -- _Ca2 enters spine via NMDA: Ca_post += k_NMDA × NT_cleft × Mg_block_removal -- Ca_post decays slowly each ms (single exponential, no pump detail) -- Ca_post_history updated every ms (feeds seconds loop) -- V_post_history updated every ms (retained for reference) - -— seconds: - -- Ca_post_history mean computed over past 2 s -- eCB synthesised when Ca_post_history mean exceeds eCB threshold -- eCB_level decays when Ca_post_history mean falls below threshold -- eCB_level written → read by presynapse as retrograde brake on VGCCs -- Ca_post_history compared to LTP/LTD thresholds → plasticity tag set - -— mins: - -- If Plasticity_LTP tagged → AMPA density increases -- If Plasticity_LTD tagged → AMPA density decreases -- AMPA density feeds back into receptor_conductance ceiling for next cycle - ---- - -**Tubs:** - -- **_Na**: Ioni entranti tramite AMPA receptors -- **_NT**: Neuro Trasmettitori -- **_Ca2**: Ioni entranti tramite NMDA -- **_VPost**: il voltage che viene sentito in DB -- **_eCB**: -- **_Nox**:? - ---- - -Intro: +Expansions and modulations: - is expanded and developed by: [D_BRANCH](d-branch.md) - is tuned by: ORGANISM, organs, modules - expands and tunes: [POST-AMPA](post_ampa.md) - develops [_posMod](??), [_actMod](??) + ## POSTSYNAPSE ```Gen -POSTSYNAPSE - type: comprehension - include: post_ampa.md +include: + post_ampa.md + +POSTSYNAPSE + + type: comprehension expansion: _@PostAmpaAll: TUB [ comprehension: POST-AMPA, full: 10x, active: 5x, empty: 2x ] @@ -98,6 +56,15 @@ POSTSYNAPSE ``` +**Tubs:** + +- **_Na**: Ioni entranti tramite AMPA receptors +- **_NT**: Neuro Trasmettitori +- **_Ca2**: Ioni entranti tramite NMDA +- **_VPost**: il voltage che viene sentito in DB +- **_eCB**: +- **_Nox**:? + ### MAIN_POST: !DAY ``` MAIN_POST