messo a posto i titoli e iniziato il tun vgcc
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+79
-68
@@ -133,10 +133,7 @@ container: PRESYNAPSE
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### AP_ctx: PRESYNAPSE
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#### ms: AP_ctx: PRESYNAPSE
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##### NTreleaseLow: interacting
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#### NTreleaseLow: int: ms
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Il rilascio di NT lo facciamo nel contesto di AP. Biologicamente dovrebbe avvenire solo in base alle concentrazioni, quindi anche al difuori degli AP.
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@@ -168,7 +165,7 @@ interacting: NTreleaseLow
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trace: None
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```
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##### NTreleaseMedium: interacting
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#### NTreleaseMedium: int: ms
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In tutti i casi di NT
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@@ -186,7 +183,7 @@ interacting: NTreleaseMedium
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trace: None
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```
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##### NTreleaseHigh: interacting
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#### NTreleaseHigh: int: ms
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```Gen
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interacting: NTreleaseHigh
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@@ -201,14 +198,17 @@ interacting: NTreleaseHigh
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trace: None
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```
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##### Ca2+TracesAccumulationLow: interacting
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#### Ca2+TracesAccumulationLow: int: ms
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Serve a dare la velocita' al trasporto di vesicles da RP a RRP.
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- The biological meaning is that a synapse that has just been through a burst is primed for fast recovery — the molecular machinery for vesicle docking is already engaged, calcium-dependent priming factors are still elevated, and the system is in a ready state. A synapse that has been silent for several seconds has cooled down and replenishes slowly.
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- So after one second of silence CaTrace has fallen to ~37% of its peak value, after two seconds to ~14%, after three seconds to ~5%. It asymptotes toward zero but never exactly reaches it. Between spikes, Ca2+ falls toward zero as the pumps clear it. The result is that CaTrace encodes not the instantaneous calcium level but the recent history of calcium activity — a smoothed, time-averaged measure of how active the synapse has been over the past one to two seconds.
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- Abbiamo 3 tracce, high, medium and low. Andiamo a verificare se una di queste e' high per fare la modulazione
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Serve a:
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- fare il tuning dei VGCC
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- dare la velocita' al trasporto di vesicles da RP a RRP, anche se non avendo ancora compreso ATP, la velocita' non cambia molto la sostanza.
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- le tracce vengono eliminate quando il neurone e' in pausa, lontano da uno spike train, TunPossible_ctx
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- Abbiamo 3 tracce, high, medium and low. Andiamo a verificare una combinazione di queste per fare la modulazione
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- RF e' a 10, questo dovrebbe essere un RF di campionamento durante AP_ctx context che dovremmo assicurarci sia tipo 100. Il che implicherebbe 10 campionamenti.
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- The biological meaning is that a synapse that has just been through a burst is primed for fast recovery — the molecular machinery for vesicle docking is already engaged, calcium-dependent priming factors are still elevated, and the system is in a ready state. A synapse that has been silent for several seconds has cooled down and replenishes slowly.
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- So after one second of silence CaTrace has fallen to ~37% of its peak value, after two seconds to ~14%, after three seconds to ~5%. It asymptotes toward zero but never exactly reaches it. Between spikes, Ca2+ falls toward zero as the pumps clear it. The result is that CaTrace encodes not the instantaneous calcium level but the recent history of calcium activity — a smoothed, time-averaged measure of how active the synapse has been over the past one to two seconds.
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---
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```Gen
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@@ -223,7 +223,7 @@ interacting: Ca2+TracesAccumulationLow
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trace: None
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```
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##### Ca2+TracesAccumulationMedium: interacting
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#### Ca2+TracesAccumulationMedium: int: ms
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```Gen
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interacting: Ca2+TracesAccumulationMedium
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@@ -237,7 +237,7 @@ interacting: Ca2+TracesAccumulationMedium
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trace: None
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```
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##### Ca2+TracesAccumulationHigh: interacting
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#### Ca2+TracesAccumulationHigh: int: ms
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```Gen
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@@ -254,11 +254,7 @@ interacting: Ca2+TracesAccumulationHigh
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### NOT AP_ctx: PRESYNAPSE
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#### ms: NOT AP_ctx: PRESYNAPSE
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#### sec: NOT AP_ctx: PRESYNAPSE
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##### eCB clearance: interacting
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#### eCB clearance: int: ms
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eCB dipende da POST. Tende a modulare l'entrata di Ca2+ degli VGCC.
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@@ -276,33 +272,7 @@ interacting: eCBClearance
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trace: None
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```
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##### Ca2+TracesClearance: interacting
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Qui non facciamo un flush di CaTraceX, riduciamo ogni mezzo secondo (context) di un RF di questo episodio.
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```Gen
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interacting: Ca2+TracesClearance
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contained_by: PRESYNAPSE
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in_context: NOT AP_ctx
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rf: ( active: 30x ) # Slow
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hypothesis: NOT (CaTraceHigh empty)
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action: [CaTRaceHigh decrease]
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trace: None
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hypothesis: NOT (CaTraceMedium empty)
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action: [CaTRaceMedium decrease]
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trace: None
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hypothesis: NOT (CaTraceLow empty)
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action: [CaTRaceLow decrease] hypothesis: NOT (CaTraceHigh empty)
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action: [CaTRaceHigh decrease]
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trace: None
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trace: None
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```
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##### RPShuttleLow: interacting
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#### RPShuttleLow: int: sec
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This happens in the seconds loop, once per second.
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@@ -324,7 +294,7 @@ interacting: RPShuttleLow
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trace: None
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```
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##### RPShuttleMedium: interacting
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#### RPShuttleMedium: int: sec
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The "Sub-Optimal" State. The machinery is working, but it's held back by partial limitations. This covers cases where the signal is steady but the "piston" isn't firing at full speed, or where a high vacancy in the RRP (emptiness) forces a low signal to work a bit harder.
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@@ -345,7 +315,7 @@ interacting: RPShuttleMedium
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trace: None
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```
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##### RPShuttleHigh: interacting
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#### RPShuttleHigh: int: sec
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The "High Performance" State. Multiple systems are optimized, but one is still at a "mediumness" level. This represents an active synapse that hasn't reached its absolute peak because either the supply is only 50% or the RRP isn't empty enough to create that "maximal vacuum" pull.
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@@ -365,9 +335,7 @@ interacting: RPShuttleHigh
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trace: None
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```
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#### min: NOT AP_ctx: PRESYNAPSE
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##### RefillRPGlutamine
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#### RefillRPGlutamine: int: min
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This happens in the minutes loop, once per minute, via the glutamine shuttle from the astrocyte. It is a two-step process across two cells.
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@@ -397,14 +365,40 @@ Gln — depletes over bursts, refilled by glucose (slowest, astrocyte-depend
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Each tier buys time for the one below it to respond. When all three are depleted simultaneously — which only happens under prolonged high-frequency firing with insufficient glucose — the synapse has no remaining buffer and goes silent until the minutes loop restores the Glutamine_pool.
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### VGCC-PRE-TUN: Tuner
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### TunPossible_ctx: PRESYNAPSE
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#### Ca2+TracesClearance: int: sec
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Qui facciamo un flush di CaTraceX.
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```Gen
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interacting: Ca2+TracesClearance
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contained_by: PRESYNAPSE
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in_context: NOT AP_ctx
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rf: ( active: 30x ) # Slow
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hypothesis: NOT (CaTraceHigh empty)
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action: [CaTRaceHigh decrease]
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trace: None
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hypothesis: NOT (CaTraceMedium empty)
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action: [CaTRaceMedium decrease]
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trace: None
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hypothesis: NOT (CaTraceLow empty)
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action: [CaTRaceLow decrease]
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trace: None
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```
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## VGCC-PRE-TUN: Tuner
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```Gen
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tuner: VGCC-PRE-TUN
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# qui stiamo aggiungendo o eliminando VGCC-PRE. Fra un massimo full e minimo empty (empty puo' non essere 0)
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contained_by: PRESYNAPSE
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# contained_by: PRESYNAPSE non e' contenuto, si attacca.
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tunes: PRESYNAPSE/expansion/VCGG-PRE
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@@ -419,7 +413,11 @@ tuner: VGCC-PRE-TUN
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tub_intricated:
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```
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#### CheckVgccPreTun:contexting
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### TunPossible_ctx: VGCC-PRE-TUN
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#### CheckVgccPreTun: contexting: sec
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Qui controlliamo che ci siano le condizioni per aumentare o diminuire la quantita' di VGCC
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```Gen
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contexting: CheckVgccPreTun
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@@ -428,17 +426,34 @@ contexting: CheckVgccPreTun
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in_context: TunPossible_ctx
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rf: ( active: 60x )
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condition:
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out_context: TryTunPreVcgg_ctx
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condition: ( CaTraceHigh fullness )
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out_context: TryTunUpPreVcgg_ctx
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condition: ( CaTraceLow fullness )
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out_context: TryTunDownPreVcgg_ctx
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```
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#### PossibleVgccPreTun: interacting
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#### PossibleUpPreVgccTun: int: sec
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```Gen
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interacting: PossibleVgccPreTun
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interacting: PossibleUpPreVgccTun
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contained_by: VGCC-PRE-TUN
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in_context: TryTunPreVcgg_ctx
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in_context: TryTunUpPreVcgg_ctx
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rf: ( active: 10x )
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hypothesis:
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action:
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trace:
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```
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#### PossibleDownPreVgccTun: int: sec
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```Gen
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interacting: PossibleDownPreVgccTun
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contained_by: VGCC-PRE-TUN
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in_context: TryTunDownPreVcgg_ctx
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rf: ( active: 10x )
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hypothesis:
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@@ -465,9 +480,7 @@ container: VGCC-PRE
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Da rivedere le condizioni per aggiungere mGluR che ha come proxy NT concentration!!!!!
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#### ms: AP_ctx: VGCC-PRE
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##### Ca2+enterLow: interacting
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#### Ca2+enterLow: int: ms
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Here we comprehend the breaking activity on VGCC by: CDI, eCB and mGluR:
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@@ -499,7 +512,7 @@ interacting: Ca2+enterLow
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trace: None
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```
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##### Ca2+enterMedium: interacting
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#### Ca2+enterMedium: int: ms
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```Gen
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interacting: Ca2+enterMedium
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@@ -515,7 +528,7 @@ interacting: Ca2+enterMedium
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trace: None
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```
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##### Ca2+enterHigh: interacting
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#### Ca2+enterHigh: int: ms
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```Gen
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interacting: Ca2+enterHigh
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@@ -532,9 +545,7 @@ interacting: Ca2+enterHigh
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### NOT AP_ctx: VGCC-PRE
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#### ms: NOT AP_ctx: VGCC-PRE
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##### Ca2+ClearanceLow: interacting
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#### Ca2+ClearanceLow: int: ms
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Qui eliminiamo Ca2+. Il tempo che ci mette ad eliminare il Ca2+ dovrebbe essere minoe dell'inervallo fra un AP_ctx e un'altra. Siccome non comprendiamo per ora ATP, non c'e' accumulo di Ca2+ per mancanza di ATP (stanchezza).
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@@ -560,7 +571,7 @@ interacting: Ca2+ClearanceLow
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trace: None
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```
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##### Ca2+ClearanceHigh: interacting
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#### Ca2+ClearanceHigh: int: ms
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```Gen
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interacting: Ca2+ClearanceHigh
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