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aggiunta comportamenti

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ocrampal
2026-04-03 16:33:48 +02:00
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2 changed files with 66 additions and 73 deletions
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neuron/BEH-AXO.md
+27 -27
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@@ -125,7 +125,7 @@ In this comprehension, we decide to simplify:
- We do not comprehend mGlur, we check for the concentration of NT in the cleft - We do not comprehend mGlur, we check for the concentration of NT in the cleft
- We do not comprehend Ca2+ buffering - We do not comprehend Ca2+ buffering
- We do not comprehend PMCA, NCX, and SERCA, we comprehend Ca2+ clearing as a slow process - We do not comprehend PMCA, NCX, and SERCA, we comprehend Ca2+ clearing as a slow process
- We do not comprehend vesicles, we comprehend them as processes releasing NT, fast, medium and slow based on conditions - We do not comprehend vesicles, we comprehend them as processes releasing NT, fast, mediumness and slow based on conditions
The simplification impies that: The simplification impies that:
@@ -221,8 +221,8 @@ context: AP-RRPConcentration
in_context: AP in_context: AP
rf: ( active: 60x ) rf: ( active: 60x )
condition: (Rrp medium) condition: (Rrp mediumness)
out_context: RRPMedium out_context: RRPmediumness
condition: (Rrp fullness) condition: (Rrp fullness)
out_context: RRPFull out_context: RRPFull
@@ -239,8 +239,8 @@ context: AP-Ca2+Concentration
in_context: AP in_context: AP
rf: ( active: 60x ) rf: ( active: 60x )
condition: (Ca2+ medium) condition: (Ca2+ mediumness)
out_context: Ca2+Medium out_context: Ca2+mediumness
condition: (Ca2+ fullness) condition: (Ca2+ fullness)
out_context: Ca2+Full out_context: Ca2+Full
@@ -286,16 +286,16 @@ episode: NTreleaseHigh
trace: None trace: None
``` ```
##### NTreleaseMedium: Episode ##### NTreleaseMediumness: Episode
In tutti i casi di NT In tutti i casi di NT
```Gen ```Gen
episode: NTreleaseMedium episode: NTreleaseMediumness
contained_by: BEH-PRE contained_by: BEH-PRE
in_context: (Ca2+Full AND RRPMedium) OR (Ca2+Medium AND RRPFull) in_context: (Ca2+Full AND RRPMediumness) OR (Ca2+Mediumness AND RRPFull)
rf: ( active: 9x ) # Medium rf: ( active: 9x ) # Mediumness
hypothesis: (NT empty) OR NOT (NT empty) hypothesis: (NT empty) OR NOT (NT empty)
action: [Rrp decrease, Nt increase, ATP decrease] action: [Rrp decrease, Nt increase, ATP decrease]
@@ -310,7 +310,7 @@ In tutti i casi di NT
episode: NTreleaseLow episode: NTreleaseLow
contained_by: BEH-PRE contained_by: BEH-PRE
in_context: (Ca2+Medium AND RRPMedium) in_context: (Ca2+Mediumness AND RRPMediumness)
rf: ( active: 12x ) # Low rf: ( active: 12x ) # Low
hypothesis: (NT empty) OR NOT (NT empty) hypothesis: (NT empty) OR NOT (NT empty)
@@ -344,14 +344,14 @@ episode: AP-CaClearanceHigh
trace: None trace: None
``` ```
##### AP-CaClearanceMedium: Episode ##### AP-CaClearanceMediumness: Episode
```Gen ```Gen
episode: AP-CaClearanceMedium episode: AP-CaClearanceMediumness
contained_by: BEH-PRE contained_by: BEH-PRE
in_context: Ca2+Medium in_context: Ca2+Mediumness
rf: ( active: 6x ) # Medium rf: ( active: 6x ) # mediumness
hypothesis: NOT (Ca2+ empty) hypothesis: NOT (Ca2+ empty)
action: [Ca2+ decrease] action: [Ca2+ decrease]
@@ -403,7 +403,7 @@ episode: CaTracesAccumulationSlow
in_context: Ca2+Full in_context: Ca2+Full
rf: ( active: 24x ) # Slow rf: ( active: 24x ) # Slow
hypothesis: (Ca2+ medium) hypothesis: (Ca2+ mediumness)
action: [CaTrace increase] action: [CaTrace increase]
trace: None trace: None
``` ```
@@ -500,17 +500,17 @@ episode: RPShuttleModerate
in_context: RPShuttle in_context: RPShuttle
rf: ( active: 24x ) # Slow rf: ( active: 24x ) # Slow
hypothesis: ((CaTrace medium) AND (RP medium) AND (RRP medium)) OR hypothesis: ((CaTrace mediumness) AND (RP mediumness) AND (RRP mediumness)) OR
((CaTrace fullness) AND (RP medium) AND (RRP medium)) OR # signal boost ((CaTrace fullness) AND (RP mediumness) AND (RRP mediumness)) OR # signal boost
((CaTrace medium) AND (RP fullness) AND (RRP medium)) OR # supply boost ((CaTrace mediumness) AND (RP fullness) AND (RRP mediumness)) OR # supply boost
((CaTrace medium) AND (RP medium) AND (RRP emptiness)) # vacancy boost ((CaTrace mediumness) AND (RP mediumness) AND (RRP emptiness)) # vacancy boost
action: [RP decrease, RRP increase] action: [RP decrease, RRP increase]
trace: None trace: None
``` ```
##### RPShuttleFast: Episode ##### RPShuttleFast: Episode
The "High Performance" State. Multiple systems are optimized, but one is still at a "Medium" level. This represents an active synapse that hasn't reached its absolute peak because either the supply is only 50% or the RRP isn't empty enough to create that "maximal vacuum" pull. The "High Performance" State. Multiple systems are optimized, but one is still at a "mediumness" level. This represents an active synapse that hasn't reached its absolute peak because either the supply is only 50% or the RRP isn't empty enough to create that "maximal vacuum" pull.
Rate: 1.25 – 1.94 Rate: 1.25 – 1.94
@@ -521,9 +521,9 @@ episode: RPShuttleFast
in_context: RPShuttle in_context: RPShuttle
rf: ( active: 12x ) # Fast rf: ( active: 12x ) # Fast
hypothesis: ((CaTrace fullness) AND (RP fullness) AND (RRP medium)) OR # signal + supply hypothesis: ((CaTrace fullness) AND (RP fullness) AND (RRP mediumness)) OR # signal + supply
((CaTrace fullness) AND (RP medium) AND (RRP emptiness)) OR # signal + vacancy ((CaTrace fullness) AND (RP mediumness) AND (RRP emptiness)) OR # signal + vacancy
((CaTrace medium) AND (RP fullness) AND (RRP emptiness)) # supply + vacancy ((CaTrace mediumness) AND (RP fullness) AND (RRP emptiness)) # supply + vacancy
action: [RP decrease, RRP increase] action: [RP decrease, RRP increase]
trace: None trace: None
``` ```
@@ -608,9 +608,9 @@ Qui sostituiamo:
- mGluR con concentrazione NT (forse su tempi di sec e quindi avremmo bisono di un altro Tub) - mGluR con concentrazione NT (forse su tempi di sec e quindi avremmo bisono di un altro Tub)
- **Open** — zero active brakes. mGluR alone never escapes this group because its ceiling is alpha_mGluR = 0.4, meaning even at full it only removes 40% of conductance, leaving 60% — still above the 85% threshold. So mGluR is irrelevant to the open/not-open boundary. Only CDI and eCB decide. - **Open** — zero active brakes. mGluR alone never escapes this group because its ceiling is alpha_mGluR = 0.4, meaning even at full it only removes 40% of conductance, leaving 60% — still above the 85% threshold. So mGluR is irrelevant to the open/not-open boundary. Only CDI and eCB decide.
- **Reduced/partial** — exactly one meaningful brake active. Either CDI has started building (medium), or eCB has risen from sustained postsynaptic activity, but not both simultaneously. The system is aware something is happening but has not compounded yet. This is the normal operating range during moderate sustained firing. - **Reduced/partial** — exactly one meaningful brake active. Either CDI has started building (mediumness), or eCB has risen from sustained postsynaptic activity, but not both simultaneously. The system is aware something is happening but has not compounded yet. This is the normal operating range during moderate sustained firing.
- **Suppressed** — two brakes multiplying. The compounding is what defines this zone — no single variable alone produces it (except CDI approaching full). 0.5 × 0.5 = 0.25 remaining is where the synapse starts losing significant transmission efficacy. Biologically this is the pre-silence warning zone: CDI is building from residual Ca²⁺ while eCB is already engaged from postsynaptic activity. - **Suppressed** — two brakes multiplying. The compounding is what defines this zone — no single variable alone produces it (except CDI approaching full). 0.5 × 0.5 = 0.25 remaining is where the synapse starts losing significant transmission efficacy. Biologically this is the pre-silence warning zone: CDI is building from residual Ca²⁺ while eCB is already engaged from postsynaptic activity.
- **Closed — CDI** = full is the only reliable hard rule. Because CDI can reach 1.0 and appears as (1 - CDI_factor) in the formula, it alone drives conductance to zero regardless of eCB and mGluR state. The three-brake overlap corner case (eCB=full + CDI=medium + mGluR=full) also reaches here, but in practice CDI reaching full is the primary biological mechanism. - **Closed — CDI** = full is the only reliable hard rule. Because CDI can reach 1.0 and appears as (1 - CDI_factor) in the formula, it alone drives conductance to zero regardless of eCB and mGluR state. The three-brake overlap corner case (eCB=full + CDI=mediumness + mGluR=full) also reaches here, but in practice CDI reaching full is the primary biological mechanism.
Devo controllare che le condizioni sotto siano esaustive. Devo controllare che le condizioni sotto siano esaustive.
@@ -637,7 +637,7 @@ episode: Ca2+enterReduced-partial
in_context: AP in_context: AP
rf: ( active: 6x ) rf: ( active: 6x )
hypothesis: (Ca2+ medium) OR ((eCB medium) AND (Ca2+ empty)) OR ((eCB full) AND (Ca2+ empty) AND (mGluR empty)) hypothesis: (Ca2+ mediumness) OR ((eCB mediumness) AND (Ca2+ empty)) OR ((eCB full) AND (Ca2+ empty) AND (mGluR empty))
action: [Ca2+ increase, ATP decrease] action: [Ca2+ increase, ATP decrease]
trace: None trace: None
``` ```
@@ -651,7 +651,7 @@ episode: Ca2+enterSupressed
in_context: AP in_context: AP
rf: ( active: 6x ) rf: ( active: 6x )
hypothesis: ((Ca2+ medium) AND (eCB full) OR (eCB medium)) hypothesis: ((Ca2+ mediumness) AND (eCB full) OR (eCB mediumness))
action: [Ca2+ increase, ATP decrease] action: [Ca2+ increase, ATP decrease]
trace: None trace: None
``` ```
neuron/BEH-BD.md
+39 -46
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@@ -166,6 +166,16 @@ The simplification implies that:
**Tubs:** **Tubs:**
**Na**: Ioni entranti tramite AMPA receptors
**NT**:
**Ca2+**: Ioni entranti tramite NMDA
**eCB**:
**Nox**:?
--- ---
```Gen ```Gen
@@ -181,7 +191,7 @@ container: BEH-POST
- Nox ( full: 100x, active: 20x, empty: 0x ) # Nitric Oxide (NO): A gas that diffuses freely. - Nox ( full: 100x, active: 20x, empty: 0x ) # Nitric Oxide (NO): A gas that diffuses freely.
- Ecb ( full: 100x, active: 20x, empty: 0x ) # Endocannabinoids (e.g., 2-AG) - eCB ( full: 100x, active: 20x, empty: 0x ) # Endocannabinoids (e.g., 2-AG)
tub_intricated: tub_intricated:
- Nt ( contained_by: BEH-SYN ) - Nt ( contained_by: BEH-SYN )
@@ -213,6 +223,10 @@ context: CheckConditionsPostMs
out_context: eCBNotEmpty out_context: eCBNotEmpty
``` ```
### sec: behaviors POST
### min: behaviors POST
#### :Episode #### :Episode
## BEH-POST-AMPA: Container ## BEH-POST-AMPA: Container
@@ -224,60 +238,39 @@ container: BEH-POST-AMPA
- Nt ( contained_by: BEH-SYN ) - Nt ( contained_by: BEH-SYN )
context_intricated: context_intricated:
- bAp ( contained_by: BEH-SOMA ) - Na ( contained_by: BEH-POST )
``` ```
### sec: behaviors POST
### min: behaviors POST
### ms: behaviors AMPA ### ms: behaviors AMPA
#### AmpaOpen: Episode #### CheckNTPost
- Timing: < 1 ms
- InContext: Glutamate > FULLNESS
- OutContext: AMPA receptor opening
- Consequence: Na⁺ influx
- Consequence: addition to local depolarization (EPSP) from AMPA activation
```Gen ```Gen
episode: AmpaOpen context: CheckNTPost
contained_by: BEH-POST
in_context: Fixed
rf: ( active: 6x )
condition: (NT mediumness)
out_context: NTMedium
condition: (NT fullness)
out_context: NTFull
```
#### AmpaOpenMaximum: Episode
```Gen
episode: AmpaOpenMaximum
contained_by: BEH-POST-AMPA contained_by: BEH-POST-AMPA
in_context: NtCapured in_context: NTMedium
rf: ( active: 1x ) rf: ( active: 2x )
hypothesis: NOT (Ca2+ full) hypothesis: (NT mediumness)
action: [Ca2+ increase] action: [Na increase]
trace: None # Se Ca+FULLNESS, lascio tracce di overflow per modulazione DOWN, da capire UP trace:
``` ```
#### Depolarization by bAP #### Depolarization by bAP
Da ricordare i Dendritic VCGG che si aprono facendo entrare Ca2+ all'arrivo di bAP. In teoria abbiamo 3 Ion Channel.
- Timing: > 1 ms
- InContext: bAP backpropagating action potential
- Consequence: addition to local depolarization (EPSP) from bAP
#### Mg²⁺ NMDA unblock
- Timing: > 1 ms
- InContext: local depolarization (EPSP) > FULLNESS (requires depolarization > -40mV)
- OutContext: NMDA Mg²⁺ unblock
#### Full Ca+ influx by NDMA
- Timing: < 1 ms
- InContext: NMDA Mg²⁺ unblock
- Consequence: Na⁺ influx
- Consequence: addition to local depolarization (EPSP) from Full NMDA activation
#### Upregulation: Observable
- Upregulation: Depolarization relieves NMDA Mg²⁺ block → Ca²⁺ influx amplification
#### Downregulation: Observable
- Downregulation: AMPA desensitization acts as low-pass filter