aggiunta comportamenti
This commit is contained in:
+27
-27
@@ -125,7 +125,7 @@ In this comprehension, we decide to simplify:
|
||||
- We do not comprehend mGlur, we check for the concentration of NT in the cleft
|
||||
- We do not comprehend Ca2+ buffering
|
||||
- We do not comprehend PMCA, NCX, and SERCA, we comprehend Ca2+ clearing as a slow process
|
||||
- We do not comprehend vesicles, we comprehend them as processes releasing NT, fast, medium and slow based on conditions
|
||||
- We do not comprehend vesicles, we comprehend them as processes releasing NT, fast, mediumness and slow based on conditions
|
||||
|
||||
The simplification impies that:
|
||||
|
||||
@@ -221,8 +221,8 @@ context: AP-RRPConcentration
|
||||
in_context: AP
|
||||
rf: ( active: 60x )
|
||||
|
||||
condition: (Rrp medium)
|
||||
out_context: RRPMedium
|
||||
condition: (Rrp mediumness)
|
||||
out_context: RRPmediumness
|
||||
|
||||
condition: (Rrp fullness)
|
||||
out_context: RRPFull
|
||||
@@ -239,8 +239,8 @@ context: AP-Ca2+Concentration
|
||||
in_context: AP
|
||||
rf: ( active: 60x )
|
||||
|
||||
condition: (Ca2+ medium)
|
||||
out_context: Ca2+Medium
|
||||
condition: (Ca2+ mediumness)
|
||||
out_context: Ca2+mediumness
|
||||
|
||||
condition: (Ca2+ fullness)
|
||||
out_context: Ca2+Full
|
||||
@@ -286,16 +286,16 @@ episode: NTreleaseHigh
|
||||
trace: None
|
||||
```
|
||||
|
||||
##### NTreleaseMedium: Episode
|
||||
##### NTreleaseMediumness: Episode
|
||||
|
||||
In tutti i casi di NT
|
||||
|
||||
```Gen
|
||||
episode: NTreleaseMedium
|
||||
episode: NTreleaseMediumness
|
||||
contained_by: BEH-PRE
|
||||
|
||||
in_context: (Ca2+Full AND RRPMedium) OR (Ca2+Medium AND RRPFull)
|
||||
rf: ( active: 9x ) # Medium
|
||||
in_context: (Ca2+Full AND RRPMediumness) OR (Ca2+Mediumness AND RRPFull)
|
||||
rf: ( active: 9x ) # Mediumness
|
||||
|
||||
hypothesis: (NT empty) OR NOT (NT empty)
|
||||
action: [Rrp decrease, Nt increase, ATP decrease]
|
||||
@@ -310,7 +310,7 @@ In tutti i casi di NT
|
||||
episode: NTreleaseLow
|
||||
contained_by: BEH-PRE
|
||||
|
||||
in_context: (Ca2+Medium AND RRPMedium)
|
||||
in_context: (Ca2+Mediumness AND RRPMediumness)
|
||||
rf: ( active: 12x ) # Low
|
||||
|
||||
hypothesis: (NT empty) OR NOT (NT empty)
|
||||
@@ -344,14 +344,14 @@ episode: AP-CaClearanceHigh
|
||||
trace: None
|
||||
```
|
||||
|
||||
##### AP-CaClearanceMedium: Episode
|
||||
##### AP-CaClearanceMediumness: Episode
|
||||
|
||||
```Gen
|
||||
episode: AP-CaClearanceMedium
|
||||
episode: AP-CaClearanceMediumness
|
||||
contained_by: BEH-PRE
|
||||
|
||||
in_context: Ca2+Medium
|
||||
rf: ( active: 6x ) # Medium
|
||||
in_context: Ca2+Mediumness
|
||||
rf: ( active: 6x ) # mediumness
|
||||
|
||||
hypothesis: NOT (Ca2+ empty)
|
||||
action: [Ca2+ decrease]
|
||||
@@ -403,7 +403,7 @@ episode: CaTracesAccumulationSlow
|
||||
in_context: Ca2+Full
|
||||
rf: ( active: 24x ) # Slow
|
||||
|
||||
hypothesis: (Ca2+ medium)
|
||||
hypothesis: (Ca2+ mediumness)
|
||||
action: [CaTrace increase]
|
||||
trace: None
|
||||
```
|
||||
@@ -500,17 +500,17 @@ episode: RPShuttleModerate
|
||||
in_context: RPShuttle
|
||||
rf: ( active: 24x ) # Slow
|
||||
|
||||
hypothesis: ((CaTrace medium) AND (RP medium) AND (RRP medium)) OR
|
||||
((CaTrace fullness) AND (RP medium) AND (RRP medium)) OR # signal boost
|
||||
((CaTrace medium) AND (RP fullness) AND (RRP medium)) OR # supply boost
|
||||
((CaTrace medium) AND (RP medium) AND (RRP emptiness)) # vacancy boost
|
||||
hypothesis: ((CaTrace mediumness) AND (RP mediumness) AND (RRP mediumness)) OR
|
||||
((CaTrace fullness) AND (RP mediumness) AND (RRP mediumness)) OR # signal boost
|
||||
((CaTrace mediumness) AND (RP fullness) AND (RRP mediumness)) OR # supply boost
|
||||
((CaTrace mediumness) AND (RP mediumness) AND (RRP emptiness)) # vacancy boost
|
||||
action: [RP decrease, RRP increase]
|
||||
trace: None
|
||||
```
|
||||
|
||||
##### RPShuttleFast: Episode
|
||||
|
||||
The "High Performance" State. Multiple systems are optimized, but one is still at a "Medium" level. This represents an active synapse that hasn't reached its absolute peak because either the supply is only 50% or the RRP isn't empty enough to create that "maximal vacuum" pull.
|
||||
The "High Performance" State. Multiple systems are optimized, but one is still at a "mediumness" level. This represents an active synapse that hasn't reached its absolute peak because either the supply is only 50% or the RRP isn't empty enough to create that "maximal vacuum" pull.
|
||||
|
||||
Rate: 1.25 – 1.94
|
||||
|
||||
@@ -521,9 +521,9 @@ episode: RPShuttleFast
|
||||
in_context: RPShuttle
|
||||
rf: ( active: 12x ) # Fast
|
||||
|
||||
hypothesis: ((CaTrace fullness) AND (RP fullness) AND (RRP medium)) OR # signal + supply
|
||||
((CaTrace fullness) AND (RP medium) AND (RRP emptiness)) OR # signal + vacancy
|
||||
((CaTrace medium) AND (RP fullness) AND (RRP emptiness)) # supply + vacancy
|
||||
hypothesis: ((CaTrace fullness) AND (RP fullness) AND (RRP mediumness)) OR # signal + supply
|
||||
((CaTrace fullness) AND (RP mediumness) AND (RRP emptiness)) OR # signal + vacancy
|
||||
((CaTrace mediumness) AND (RP fullness) AND (RRP emptiness)) # supply + vacancy
|
||||
action: [RP decrease, RRP increase]
|
||||
trace: None
|
||||
```
|
||||
@@ -608,9 +608,9 @@ Qui sostituiamo:
|
||||
- mGluR con concentrazione NT (forse su tempi di sec e quindi avremmo bisono di un altro Tub)
|
||||
|
||||
- **Open** — zero active brakes. mGluR alone never escapes this group because its ceiling is alpha_mGluR = 0.4, meaning even at full it only removes 40% of conductance, leaving 60% — still above the 85% threshold. So mGluR is irrelevant to the open/not-open boundary. Only CDI and eCB decide.
|
||||
- **Reduced/partial** — exactly one meaningful brake active. Either CDI has started building (medium), or eCB has risen from sustained postsynaptic activity, but not both simultaneously. The system is aware something is happening but has not compounded yet. This is the normal operating range during moderate sustained firing.
|
||||
- **Reduced/partial** — exactly one meaningful brake active. Either CDI has started building (mediumness), or eCB has risen from sustained postsynaptic activity, but not both simultaneously. The system is aware something is happening but has not compounded yet. This is the normal operating range during moderate sustained firing.
|
||||
- **Suppressed** — two brakes multiplying. The compounding is what defines this zone — no single variable alone produces it (except CDI approaching full). 0.5 × 0.5 = 0.25 remaining is where the synapse starts losing significant transmission efficacy. Biologically this is the pre-silence warning zone: CDI is building from residual Ca²⁺ while eCB is already engaged from postsynaptic activity.
|
||||
- **Closed — CDI** = full is the only reliable hard rule. Because CDI can reach 1.0 and appears as (1 - CDI_factor) in the formula, it alone drives conductance to zero regardless of eCB and mGluR state. The three-brake overlap corner case (eCB=full + CDI=medium + mGluR=full) also reaches here, but in practice CDI reaching full is the primary biological mechanism.
|
||||
- **Closed — CDI** = full is the only reliable hard rule. Because CDI can reach 1.0 and appears as (1 - CDI_factor) in the formula, it alone drives conductance to zero regardless of eCB and mGluR state. The three-brake overlap corner case (eCB=full + CDI=mediumness + mGluR=full) also reaches here, but in practice CDI reaching full is the primary biological mechanism.
|
||||
|
||||
Devo controllare che le condizioni sotto siano esaustive.
|
||||
|
||||
@@ -637,7 +637,7 @@ episode: Ca2+enterReduced-partial
|
||||
in_context: AP
|
||||
rf: ( active: 6x )
|
||||
|
||||
hypothesis: (Ca2+ medium) OR ((eCB medium) AND (Ca2+ empty)) OR ((eCB full) AND (Ca2+ empty) AND (mGluR empty))
|
||||
hypothesis: (Ca2+ mediumness) OR ((eCB mediumness) AND (Ca2+ empty)) OR ((eCB full) AND (Ca2+ empty) AND (mGluR empty))
|
||||
action: [Ca2+ increase, ATP decrease]
|
||||
trace: None
|
||||
```
|
||||
@@ -651,7 +651,7 @@ episode: Ca2+enterSupressed
|
||||
in_context: AP
|
||||
rf: ( active: 6x )
|
||||
|
||||
hypothesis: ((Ca2+ medium) AND (eCB full) OR (eCB medium))
|
||||
hypothesis: ((Ca2+ mediumness) AND (eCB full) OR (eCB mediumness))
|
||||
action: [Ca2+ increase, ATP decrease]
|
||||
trace: None
|
||||
```
|
||||
|
||||
Reference in New Issue
Block a user