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Update 2026-06-04-modulation-of-future-behavior.md

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ocrampal
2026-06-05 13:55:08 +02:00
parent 53e0c7c863
commit 2a96e285af
1 changed files with 26 additions and 26 deletions
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elements/astrocyte/appunti/2026-06-04-modulation-of-future-behavior.md
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@@ -123,12 +123,12 @@ The astrocyte's perisynaptic wall distance is the variable that makes both outco
// Astrocyte: overflow sensing and co-agonist release // Astrocyte: overflow sensing and co-agonist release
glutamate_spillover = extrasynaptic_diffusion(glutamate_cleft) glutamate_spillover = extrasynaptic_diffusion(glutamate_cleft)
if glutamate_spillover > spillover_threshold: if glutamate_spillover > spillover_threshold:
mGluR5_activation = True // Gq arm → IP3 → Ca²⁺ → D-serine mGluR5_activation = True // Gq arm → IP3 → Ca²⁺ → D-serine
astro_Ca_local += IP3_cascade(PLC) astro_Ca_local += IP3_cascade(PLC)
D_serine_release += proportional_to(astro_Ca_local) D_serine_release += proportional_to(astro_Ca_local)
mGluR2_3_activation = True // Gi arm → brake presynapse mGluR2_3_activation = True // Gi arm → brake presynapse
cAMP_level -= Gi_inhibition(adenylyl_cyclase) cAMP_level -= Gi_inhibition(adenylyl_cyclase)
vesicle_release_prob -= VGCC_suppression() // autoinhibitory brake vesicle_release_prob -= VGCC_suppression() // autoinhibitory brake
// Astrocyte: check for network overload // Astrocyte: check for network overload
astro_Ca_global = soma_wave(astro_Ca_local > OVERLOAD_threshold) astro_Ca_global = soma_wave(astro_Ca_local > OVERLOAD_threshold)
@@ -140,9 +140,9 @@ The astrocyte's perisynaptic wall distance is the variable that makes both outco
// NMDA gate: coincidence check // NMDA gate: coincidence check
if membrane_potential > -40mV and D_serine_release > threshold: if membrane_potential > -40mV and D_serine_release > threshold:
NMDA_Mg_block = False // Mg²⁺ ejected NMDA_Mg_block = False // Mg²⁺ ejected
post_Ca_amplitude += NMDA_influx(glutamate_cleft) post_Ca_amplitude += NMDA_influx(glutamate_cleft)
post_Ca_rise_speed = d(post_Ca_amplitude) / dt post_Ca_rise_speed = d(post_Ca_amplitude) / dt
// Astrocyte: vacuum trailing echoes + fuel pipeline // Astrocyte: vacuum trailing echoes + fuel pipeline
glutamate_cleft -= glutamate_clearance_rate × Δt glutamate_cleft -= glutamate_clearance_rate × Δt
@@ -156,32 +156,32 @@ The astrocyte's perisynaptic wall distance is the variable that makes both outco
// Presynapse: facilitate or depress based on Ca²⁺ history // Presynapse: facilitate or depress based on Ca²⁺ history
if input_freq > 20Hz: if input_freq > 20Hz:
vesicle_release_prob *= 1.3 // residual Ca²⁺ primes launchpad vesicle_release_prob *= 1.3 // residual Ca²⁺ primes launchpad
mobilize(reserve_pool → RRP_pool) // break storage chains mobilize(reserve_pool → RRP_pool) // break storage chains
elif input_freq < 5Hz: elif input_freq < 5Hz:
vesicle_release_prob *= 0.7 // RRP depleted faster than refill vesicle_release_prob *= 0.7 // RRP depleted faster than refill
// Postsynapse: NMDA gate primed if frequency sustained // Postsynapse: NMDA gate primed if frequency sustained
if input_freq >= 50Hz and duration > 1s: if input_freq >= 50Hz and duration > 1s:
NMDA_Mg_block = False // sustained depolarization NMDA_Mg_block = False // sustained depolarization
post_Ca_amplitude accumulates // early-LTP signal rises post_Ca_amplitude accumulates // early-LTP signal rises
// Astrocyte: sustained volume → escalate co-agonist // Astrocyte: sustained volume → escalate co-agonist
if astro_Ca_local > local_threshold: if astro_Ca_local > local_threshold:
D_serine_release += gliotransmitter_pulse() // widens NMDA window D_serine_release += gliotransmitter_pulse() // widens NMDA window
// Neuromodulators: set context gate via Gs protein // Neuromodulators: set context gate via Gs protein
if dopamine_level > D1_threshold or NE_level > β_threshold: if dopamine_level > D1_threshold or NE_level > β_threshold:
cAMP_level += Gs_activation(adenylyl_cyclase) cAMP_level += Gs_activation(adenylyl_cyclase)
PKA_activity = proportional_to(cAMP_level) PKA_activity = proportional_to(cAMP_level)
phosphorylate(GluA1, site=Ser845) phosphorylate(GluA1, site=Ser845)
GluA1_Ser845_primed = True // lowers CaMKII threshold GluA1_Ser845_primed = True // lowers CaMKII threshold
phosphorylate(DARPP32) phosphorylate(DARPP32)
DARPP32_phospho = True // silences PP1 — blocks LTD DARPP32_phospho = True // silences PP1 — blocks LTD
translocate(PKA → nucleus) → phosphorylate(CREB) translocate(PKA → nucleus) → phosphorylate(CREB)
CREB_active = True // enables structural gene expression CREB_active = True // enables structural gene expression
// Acetylcholine: lower LTP threshold globally // Acetylcholine: lower LTP threshold globally
LTP_threshold *= (1 / (1 + ACh_level × mAChR_gain)) LTP_threshold *= (1 / (1 + ACh_level × mAChR_gain))
## slow time scale — structural commit (h → weeks) ## slow time scale — structural commit (h → weeks)