spostato il clearance Ca2+ dalla presynapse in VGCC dove si creano i Ca2+

neuron/presynapse.md

@@ -199,64 +199,10 @@ interacting: NTreleaseHigh
     trace: None
 ```
 
-##### AP-CaClearanceMedium: interacting
-
-Qui eliminiamo Ca2+. Non comprendiamo per ora:
-
-- PMCA: primary, ATP-dependent
-- NCX: fast, NOT ATP-dependent
-- SERCA: slowest, ATP-dependent
-
-Quindi non comprendiamo anche il ristabilimento del Voltage, con altri Ioni entranti e uscenti, per ora tutto dipende da AP del SOMA.
-
-Abbiamo il caso di clearance nel contesto di un AP e non nel contesto di AP, per eliminare il Ca2+ fra le spike.
-
----
-
-```Gen
-interacting: AP-CaClearanceMedium
-  contained_by: PRESYNAPSE
-
-  in_context: AP_ctx
-  rf: ( active: 6x ) # mediumness
-
-  hypothesis: (Ca2+ mediumness)
-    action: [Ca2+ decrease]
-    trace: None
-```
-
-##### AP-CaClearanceHigh: interacting
-
-```Gen
-interacting: AP-CaClearanceHigh
-  contained_by: PRESYNAPSE
-
-  in_context: AP_ctx
-  rf: ( active: 3x ) # High
-
-  hypothesis: (Ca2+ fullness)
-    action: [Ca2+ decrease]
-    trace: None
-```
-
 ### NOT AP_ctx: PRESYNAPSE
 
 #### ms: NOT AP_ctx: PRESYNAPSE
 
-##### NotAP-CaClearance: interacting
-
-```Gen
-interacting: NotAP-CaClearance
-  contained_by: PRESYNAPSE
-
-  in_context: NOT AP_ctx
-  rf: ( active: 24x ) # Low
-
-  hypothesis: NOT (Ca2+ empty)
-    action: [Ca2+ decrease]
-    trace: None
-```
-
 ##### CaTracesAccumulationLow: interacting
 
 Serve a dare la velocita' al trasporto di vesicles da RP a RRP. The biological meaning is that a synapse that has just been through a burst is primed for fast recovery — the molecular machinery for vesicle docking is already engaged, calcium-dependent priming factors are still elevated, and the system is in a ready state. A synapse that has been silent for several seconds has cooled down and replenishes slowly.
@@ -561,3 +507,45 @@ interacting: Ca2+enterHigh
     action: [Ca2+ increase, ATP decrease]
     trace: None
 ```
+
+### NOT AP_ctx: VGCC-PRE
+
+#### ms: NOT AP_ctx: VGCC-PRE
+
+##### CaClearanceLow: interacting
+
+Qui eliminiamo Ca2+. Non non comprendiamo anche il ristabilimento del Voltage, con altri Ioni entranti e uscenti, per ora tutto dipende da AP del SOMA. Non comprendiamo per ora:
+- PMCA: primary, ATP-dependent
+- NCX: fast, NOT ATP-dependent
+- SERCA: slowest, ATP-dependent
+
+Qui disinguiamo:
+- Ca+2 fullness che si puo' verificare alla fine di un AP
+- NOT ca2+ fullness che svuota piu' lentamente
+- da capire se serve veramente questa distinzione anche in bae alle tracce di Ca2+ che prendiamo in presynapse.
+
+```Gen
+interacting: NotAP-CaClearance
+  contained_by: PRESYNAPSE
+
+  in_context: NOT AP_ctx
+  rf: ( active: 24x ) # Low
+
+  hypothesis: (NOT Ca2+ fullness) AND (NOT Ca2+ empty) 
+    action: [Ca2+ decrease]
+    trace: None
+```
+
+##### CaClearanceHigh: interacting
+
+```Gen
+interacting: NotAP-CaClearance
+  contained_by: PRESYNAPSE
+
+  in_context: NOT AP_ctx
+  rf: ( active: 4x ) # High
+
+  hypothesis: NOT (Ca2+ empty)
+    action: [Ca2+ decrease]
+    trace: None
+