diff --git a/neuron/presynapse.md b/neuron/presynapse.md index f3e4cc3..e1deacb 100644 --- a/neuron/presynapse.md +++ b/neuron/presynapse.md @@ -199,64 +199,10 @@ interacting: NTreleaseHigh trace: None ``` -##### AP-CaClearanceMedium: interacting - -Qui eliminiamo Ca2+. Non comprendiamo per ora: - -- PMCA: primary, ATP-dependent -- NCX: fast, NOT ATP-dependent -- SERCA: slowest, ATP-dependent - -Quindi non comprendiamo anche il ristabilimento del Voltage, con altri Ioni entranti e uscenti, per ora tutto dipende da AP del SOMA. - -Abbiamo il caso di clearance nel contesto di un AP e non nel contesto di AP, per eliminare il Ca2+ fra le spike. - ---- - -```Gen -interacting: AP-CaClearanceMedium - contained_by: PRESYNAPSE - - in_context: AP_ctx - rf: ( active: 6x ) # mediumness - - hypothesis: (Ca2+ mediumness) - action: [Ca2+ decrease] - trace: None -``` - -##### AP-CaClearanceHigh: interacting - -```Gen -interacting: AP-CaClearanceHigh - contained_by: PRESYNAPSE - - in_context: AP_ctx - rf: ( active: 3x ) # High - - hypothesis: (Ca2+ fullness) - action: [Ca2+ decrease] - trace: None -``` - ### NOT AP_ctx: PRESYNAPSE #### ms: NOT AP_ctx: PRESYNAPSE -##### NotAP-CaClearance: interacting - -```Gen -interacting: NotAP-CaClearance - contained_by: PRESYNAPSE - - in_context: NOT AP_ctx - rf: ( active: 24x ) # Low - - hypothesis: NOT (Ca2+ empty) - action: [Ca2+ decrease] - trace: None -``` - ##### CaTracesAccumulationLow: interacting Serve a dare la velocita' al trasporto di vesicles da RP a RRP. The biological meaning is that a synapse that has just been through a burst is primed for fast recovery — the molecular machinery for vesicle docking is already engaged, calcium-dependent priming factors are still elevated, and the system is in a ready state. A synapse that has been silent for several seconds has cooled down and replenishes slowly. @@ -561,3 +507,45 @@ interacting: Ca2+enterHigh action: [Ca2+ increase, ATP decrease] trace: None ``` + +### NOT AP_ctx: VGCC-PRE + +#### ms: NOT AP_ctx: VGCC-PRE + +##### CaClearanceLow: interacting + +Qui eliminiamo Ca2+. Non non comprendiamo anche il ristabilimento del Voltage, con altri Ioni entranti e uscenti, per ora tutto dipende da AP del SOMA. Non comprendiamo per ora: +- PMCA: primary, ATP-dependent +- NCX: fast, NOT ATP-dependent +- SERCA: slowest, ATP-dependent + +Qui disinguiamo: +- Ca+2 fullness che si puo' verificare alla fine di un AP +- NOT ca2+ fullness che svuota piu' lentamente +- da capire se serve veramente questa distinzione anche in bae alle tracce di Ca2+ che prendiamo in presynapse. + +```Gen +interacting: NotAP-CaClearance + contained_by: PRESYNAPSE + + in_context: NOT AP_ctx + rf: ( active: 24x ) # Low + + hypothesis: (NOT Ca2+ fullness) AND (NOT Ca2+ empty) + action: [Ca2+ decrease] + trace: None +``` + +##### CaClearanceHigh: interacting + +```Gen +interacting: NotAP-CaClearance + contained_by: PRESYNAPSE + + in_context: NOT AP_ctx + rf: ( active: 4x ) # High + + hypothesis: NOT (Ca2+ empty) + action: [Ca2+ decrease] + trace: None +