NT arrives in cleft → AMPA receptors bind NT (receptor availability constant, no desensitization)
V_post rises with AMPA conductance, decays passively each ms
bAP arrives → V_post receives additional depolarisation boost
NMDA gate checks coincidence: NT_cleft AND V_post both non-zero
Mg_block_removal = V_post / (V_post + V_NMDA_half) — sigmoid of V_post
Ca²⁺ enters spine via NMDA: Ca_post += k_NMDA × NT_cleft × Mg_block_removal
Ca_post decays slowly each ms (single exponential, no pump detail)
Ca_post_history updated every ms (feeds seconds loop)
V_post_history updated every ms (retained for reference)

— seconds:

Ca_post_history mean computed over past 2 s
eCB synthesised when Ca_post_history mean exceeds eCB threshold
eCB_level decays when Ca_post_history mean falls below threshold
eCB_level written → read by presynapse as retrograde brake on VGCCs
Ca_post_history compared to LTP/LTD thresholds → plasticity tag set

— mins:

If Plasticity_LTP tagged → AMPA density increases
If Plasticity_LTD tagged → AMPA density decreases
AMPA density feeds back into receptor_conductance ceiling for next cycle

G expression:


bAP_ctx
    POSTSYNAPSE (ms)
      -- Ca Influx
      CaNDMAEnterMax: ( active: 2x ) accumulator
      CaNDMAEnterMed: ( active: 4x ) accumulator

NOT bAP_ctx:
    POSTSYNAPSE (ms)
      -- Ca Influx
      CaNDMAEnterMedNotBap: ( active: 4x ) accumulator
      CaNDMAEnterLow: ( active: 12x ) accumulator
      -- Ca Clearence
      CaClearance: ( active: 24x ) accumulator
      -- V Influx
      VPostMax: ( active: 4x ) accumulator ->VPost 
      VPostMed: ( active: 8x ) accumulator ->VPost
      VPostLow: ( active: 16x ) accumulator ->VPost
      -- V Clearence
      VPostClearance: ( active: 18x ) accumulator ~->VPost
    POST-AMPA (ms) ~ NT
        -- Na Influx
        NaAMPAEnterMax: ( active: 2x ) accumulator ~NT
        NaAMPAEnterMed: ( active: 4x ) accumulator ~NT
    POST-NA-CLEAR (ms)
        -- Na Clearence
        NaClearanceHigh: ( active: 4x ) accumulator
        NaClearanceLow: ( active: 16x ) accumulator

TunPossible_ctx
    TUN-POST-AMPA (sec)
      CheckTunPostAmpa: ( active: 60x ) contexting
          TryTunUpPostAmpa_ctx
              PossibleUpPostAmpaTun: ( active: 10x ) accumulator
          TryTunDownPostAmpa_ctx
              PossibleDownPostAmpaTun: ( active: 10x ) accumulator

Tubs:

Na: Ioni entranti tramite AMPA receptors
NT:
Ca2+: Ioni entranti tramite NMDA
VPost: il voltage che viene sentito in DB
eCB:
Nox:?

POSTSYNAPSE: Comprehension

POSTSYNAPSE
 type: comprehension

 expand_comprehension: 
    &POST-AMPA_ALL: POST-AMPA (full: 10x, active: 5x, empty: 2x)
    @: POST-NA-CLEAR (full: 1x, active: 1x, empty: 0x)

 instantiate_container:
    POSTSYNAPSE-BEH []
    TUN-POST-AMPA [pass: POST-AMPA_ALL]

POSTSYNAPSE: Container

POSTSYNAPSE-BEH

  type: container

  activity_scope: !DAY

  tub_local:
    - Ca2+ ( full: 60x, active: 30x, empty: 0x )
    - Na ( full: 60x, active: 30x, empty: 0x )
    - Nox ( full: 100x, active: 20x, empty: 0x ) # Nitric Oxide (NO):  A gas that diffuses freely.
    - eCB ( full: 100x, active: 20x, empty: 0x ) # Endocannabinoids (e.g., 2-AG)

 tub_intricated:
  - NT ( contained_by: SYNAPSE )
  - VPost ( contained_by: BD )

 context_intricated:
  - bAp_ctx ( contained_by: SOMA )

bAp_ctx

CaNDMAEnterMax: ( active: 2x ) accumulator

CaNDMAEnterMax: ( active: 2x )
  type: accumulator
  contained_by: POSTSYNAPSE-BEH

  in_context: bAp_ctx
    hypothesis: NOT (Ca2+ full) AND
               (Na fullness OR Na mediumness)
      action: [Ca2+ increase]
      trace:

CaNDMAEnterMed: ( active: 4x ) accumulator

CaNDMAEnterMed: ( active: 4x )
  type: accumulator
  contained_by: POSTSYNAPSE-BEH

  in_context: bAp_ctx
    hypothesis: NOT (Ca2+ full) AND (Na emptiness)
      action: [Ca2+ increase]
      trace:

NOT bAp_ctx

CaNDMAEnterLow: ( active: 12x ) accumulator

CaNDMAEnterLow: ( active: 12x )
  type: accumulator
  contained_by: POSTSYNAPSE-BEH

  in_context: NOT bAP_ctx
    hypothesis: NOT (Ca2+ full) AND (Na mediumness)
      action: [Ca2+ increase]
      trace:

CaNDMAEnterMedNotBap: ( active: 4x ) accumulator

CaNDMAEnterMedNotBap: ( active: 4x )
  type: accumulator
  contained_by: POSTSYNAPSE-BEH

  in_context: NOT bAP_ctx
    hypothesis: NOT (Ca2+ full) AND (Na fullness)
      action: [Ca2+ increase]
      trace:

CaClearance: ( active: 24x ) accumulator

CaClearance: ( active: 24x ) # Low
  type: accumulator
  contained_by: POSTSYNAPSE-BEH

  in_context: NOT bAP_ctx
    hypothesis: NOT (Ca2+ empty)
      action: [Ca2+ decrease]
      trace: None

VPostMax: ( active: 4x ) accumulator

VPostMax: ( active: 4x )
  type: accumulator
  contained_by: POSTSYNAPSE-BEH

  in_context: NOT bAP_ctx
    hypothesis: ( NA fullness )
      action: [VPost increase]
      trace: None

VPostMed: ( active: 8x ) accumulator

VPostMed: ( active: 8x )
  type: accumulator
  contained_by: POSTSYNAPSE-BEH

  in_context: NOT bAP_ctx
    hypothesis: ( NA mediumness )
      action: [VPost increase]
      trace: None

VPostMin: ( active: 16x ) accumulator

VPostMin: ( active: 16x )
  type: accumulator
  contained_by: POSTSYNAPSE-BEH

  in_context: NOT bAP_ctx
    hypothesis: ( NA emptiness )
      action: [VPost increase]
      trace: None

Il VPost clearance lo facciamo qui nel container dove creaiamo anche i VPost, perche' altrimenti, se lo facessimo in DB, perderemmo l'aspetto temporale della contribuzione dei singoli POST.

VPostClearance: ( active: 18x ) accumulator

VPostClearance: ( active: 18x )
  type: accumulator
  contained_by: POSTSYNAPSE-BEH

  in_context: NOT bAP_ctx
    hypothesis: NOT ( VPost empty )
      action: [VPost decrease]
      trace: None

Il NA clearance lo mettiamo qui come sniplet, perche' gli AMPA creano, e questi pompano fuori. Qui non e' un problema di perdere l'integrazione temporale, perche' gli AMPA sono tutti uguali nel loro behavior. Abbiamo messo gli AMPA come container perche' cosi' possiamo modularne la numerosita'.

NaClearanceHigh: ( active: 4x ) accumulator

NaClearanceHigh: ( active: 4x )
  type: accumulator
  contained_by: POST-NA-CLEAR-BHE

  in_context: NOT bAP_ctx ??any??
    hypothesis: ( Na mediumness ) OR ( Na fullness )
      action: [Na decrease]
      trace: None

NaClearanceLow: ( active: 16x ) accumulator

NaClearanceLow: ( active: 16x )
  type: accumulator
  contained_by: POST-NA-CLEAR-BHE

  in_context: NOT bAP_ctx ??any??
    hypothesis: NOT (Na empty)
      action: [Na decrease]
      trace: None

TUN-POST-AMPA: Container

TUN-POST-AMPA
  type: container
  activity_scope: !DAY
  
  tub_modulation: # in TUN agiamo su POS/ACT
   - posMod ( fullness: None, active: BEH-POST-IC/fullness, empty: 0x)  # riferimento a possible di BEH-PRE
   - actMod ( fullness: None, active: BEH-POST-IC/active, empty: BEH-POST-IC/emptiness)  # riferimento a active di BEH-PRE

  context_intricated:
  - TunPossible ( contained_by: DAY-N )

  tub_local:

  tub_intricated:

CheckTunPostAmpa: ( active: 60x ) contextor

  CheckTunPostAmpa: ( active: 60x )
  type: contextor
  contained_by: TUN-POST-AMPA

  in_context: TunPossible_ctx
    condition:   tbd1
    out_context: TryTunUpPostAmpa_ctx

    condition:   tbd2
    out_context: TryTunDownPostAmpa_ctx

PossibleUpPostAmpaTun: ( active: 10x ) accumulator

PossibleUpPostAmpaTun: ( active: 10x )
  type: accumulator
  contained_by: TUN-POST-AMPA

  in_context: TryTunUpPostAmpa_ctx
    hypothesis:  
      action: 
      trace:

PossibleDownPostAmpaTun: ( active: 10x ) accumulator

PossibleDownPostAmpaTun: ( active: 10x )
  type: accumulator
  contained_by: TUN-POST-AMPA

  in_context: TryTunDownPostAmpa_ctx
    hypothesis:  
      action: 
      trace:

POST-AMPA: Comprehension

POST-AMPA
  type: comprehension

  instantiate_container:
      POST-AMPA-BHE []

POST-AMPA: Container

POST-AMPA-BHE
  type: container

  activity_scope: !DAY

  tub_intricated:
    - NT ( contained_by: ASTROCYTE/SYNAPSE )

  context_intricated:
    - Na ( contained_by: POSTSYNAPSE )

NOT bAP_ctx

NaAMPAEnterMax: ( active: 2x ) accumulator

NaAMPAEnterMax: ( active: 2x )
  type: accumulator
  contained_by: POST-AMPA-BHE

  in_context: NOT bAP_ctx
    hypothesis: (NT fullness)
      action: [Na increase]
      trace:

NaAMPAEnterMed: ( active: 4x ) accumulator

NaAMPAEnterMed: ( active: 4x )
  type: accumulator
  contained_by: POST-AMPA-BHE

  in_context: NOT bAP_ctx
    hypothesis: (NT mediumness)
      action: [Na increase]
      trace:

9.0 KiB Raw Blame History Unescape Escape

postsynapse.md