BEH-AXO.md

Qui comprendiamo:

BEH-BD: Dendritic Branch
BEH-POST: Postsynapsis
BEH-POST-AMPA: AMPA receptors (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors)

BEH-BD: Container

Dendritic Branch: In questa prima fase, non consideriamo lo spike dendritico come comportamento. Questo limita molto il modello, perche' equipara tutte le Postsinapsi sui tre branch dendritici e non permette di fare in maniera che ad esempio due branch contestualizzino (base activity) e uno faccia scattare il threshold per lo spike somatico. Qui BEH-DB espande solo i BEH-POST, e' un cavo di collegamento come l'assone

Container: BEH-BD
 
 expansion:
  - BEH-POST ( fullness: 50x, active: 20x, emptiness: 10x ) 
   # modulated_by: TUN-SYN-BD-POST possible/actual

BEH-POST: Container

container: BEH-POST

 expansion: 
  - BEH-POST-AMPA ( fullness: 10x, active: 5x, emptiness: 2x )
   # modulated_by: TUN-POST-IC # possible/actual

 tub_local:
  - Ca2+ ( fullness: 60x, active: 30x, emptiness: 0x )
   # modulated_by: DEV-POST-???-FULL # Full 

  - Nox ( fullness: 100x, active: 20x, emptiness: 0x ) # Nitric Oxide (NO):  A gas that diffuses freely.

  - Ecb ( fullness: 100x, active: 20x, emptiness: 0x ) # Endocannabinoids (e.g., 2-AG)

 tub_intricated:
  - Nt ( contained_by: BEH-SYN )
  - bAp ( contained_by: BEH-SOMA )

Context

context: captureNt
 contained_by: BEH-POST

 in_context: Fixed
 rf: ( active: 10x )

 condition: (Nt full) AND NOT (bAp)
  out_context: NtCaptured

Episode

BEH-POST-AMPA: Container

container: BEH-POST-AMPA

 tub_intricated:
  - Nt ( contained_by: BEH-SYN )

 context_intricated:
  - bAp ( contained_by: BEH-SOMA )

AmpaOpen: Episode

Timing: < 1 ms
InContext: Glutamate > FULLNESS
OutContext: AMPA receptor opening
Consequence: Na⁺ influx
Consequence: addition to local depolarization (EPSP) from AMPA activation

episode: AmpaOpen
  contained_by: BEH-POST-AMPA

  in_context: NtCapured
  rf: ( active: 1x )

 hypothesis: NOT (Ca2+ full)
  action: [Ca2+ increase]
  trace: None # Se Ca+FULLNESS, lascio tracce di overflow per modulazione DOWN, da capire UP

Depolarization by bAP

Da ricordare i Dendritic VCGG che si aprono facendo entrare Ca2+ all'arrivo di bAP. In teoria abbiamo 3 Ion Channel.

Timing: > 1 ms
InContext: bAP backpropagating action potential
Consequence: addition to local depolarization (EPSP) from bAP

Mg²⁺ NMDA unblock

Timing: > 1 ms
InContext: local depolarization (EPSP) > FULLNESS (requires depolarization > -40mV)
OutContext: NMDA Mg²⁺ unblock

Full Ca+ influx by NDMA

Timing: < 1 ms
InContext: NMDA Mg²⁺ unblock
Consequence: Na⁺ influx
Consequence: addition to local depolarization (EPSP) from Full NMDA activation

Upregulation: Observable

Upregulation: Depolarization relieves NMDA Mg²⁺ block → Ca²⁺ influx amplification

Downregulation: Observable

Downregulation: AMPA desensitization acts as low-pass filter

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